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公开(公告)号：EP1625126A1
公开(公告)日：2006-02-15
申请号：EP04731525.4
申请日：2004-05-06
申请人： AstraZeneca AB
IPC分类号： C07D471/04 , C07D513/04 , C07D498/04 , A61K31/437 , A61P11/06 , A61P37/00 , A61P19/02
CPC分类号： C07D513/04 , C07D471/04
摘要： The present invention relates to novel imidazo and thiazolopyridine compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them. Formula (I)
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公开(公告)号：EP1562902A1
公开(公告)日：2005-08-17
申请号：EP03811170.4
申请日：2003-11-11
申请人： AstraZeneca AB
发明人： BLADH, Hakan , KLINGSTEDT, Tomas , LARSSON, Joakim , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , NIKITIDIS, Grigorios
IPC分类号： C07D211/86 , C07D239/22 , A61K31/4412 , A61K31/505 , A61P29/00
CPC分类号： C07D213/64 , C07D213/82 , C07D239/557 , C07D241/24 , C07D413/12
摘要： There are provided novel compounds of formula (I) wherein R1, R4, R5, G1, G2, X, L, Y1, Y2 and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
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公开(公告)号：EP1263724B1
公开(公告)日：2005-05-18
申请号：EP01908557.0
申请日：2001-02-23
申请人： AstraZeneca AB
发明人： BODKIN, Michael Lilly Research Centre , ERIKSSON, Tomas , HANSEN, Peter , HEMMERLING, Martin , HENRIKSSON, Krister , KLINGSTEDT, Tomas , PETTERSSON, Lars
IPC分类号： C07D207/04 , C07D211/06 , C07D295/08 , A61K31/40 , A61K31/435 , A61P11/00 , A61P37/00 , A61P19/00 , A61P31/00
CPC分类号： C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/46 , C07D211/58 , C07D295/088 , C07D401/12 , C07D403/12 , C07D471/04
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4.发明公开PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES 有权BENZODIOXINYL-SUBSTITUIERTE INDAZOLDERIVATE
公开(公告)号：EP2291369A1
公开(公告)日：2011-03-09
申请号：EP09750866.7
申请日：2009-05-20
申请人： AstraZeneca AB
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula la: (Ia) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：EP1299357A1
公开(公告)日：2003-04-09
申请号：EP01941406.9
申请日：2001-06-14
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , A61K31/445
CPC分类号： C07D211/58
摘要： The invention provides compounds of general formula (I) wherein m, n, Q, Z?1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8¿ are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了通式（I）的化合物，其中m，n，Q，Z 1，Z 2，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如说明书中所定义， ，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：EP1263724A1
公开(公告)日：2002-12-11
申请号：EP01908557.0
申请日：2001-02-23
申请人： AstraZeneca AB
发明人： BODKIN, MichaelLilly Research Centre , ERIKSSON, Tomas , HANSEN, Peter , HEMMERLING, Martin , HENRIKSSON, Krister , KLINGSTEDT, Tomas , PETTERSSON, Lars
IPC分类号： C07D207/04 , C07D211/06 , C07D295/08 , A61K31/40 , A61K31/435 , A61P11/00 , A61P37/00 , A61P19/00 , A61P31/00
CPC分类号： C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/46 , C07D211/58 , C07D295/088 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The invention provides compounds of general formula (I) wherein Q, R, R?2, R4, R5, R6, R7 and R8¿ are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了其中Q，R 1，R 2，R 4，R 5，R 6，R 7和R 8如说明书中所定义的通式（I）的化合物，其制备方法，含有它们的药物组合物及其在治疗中的用途 。
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公开(公告)号：EP2291369B1
公开(公告)日：2015-11-04
申请号：EP09750866.7
申请日：2009-05-20
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
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公开(公告)号：EP1625126B1
公开(公告)日：2008-01-16
申请号：EP04731525.4
申请日：2004-05-06
申请人： AstraZeneca AB
IPC分类号： C07D471/04 , C07D513/04 , C07D498/04 , A61K31/437 , A61P11/06 , A61P37/00 , A61P19/02
CPC分类号： C07D513/04 , C07D471/04
摘要： The present invention relates to novel imidazo and thiazolopyridine compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them. Formula (I)
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公开(公告)号：EP1562902B1
公开(公告)日：2006-05-03
申请号：EP03811170.4
申请日：2003-11-11
申请人： AstraZeneca AB
发明人： BLADH, Hakan , KLINGSTEDT, Tomas , LARSSON, Joakim , LAWITZ, Karolina , LEPISTÖ, Matti , LÖNN, Hans , NIKITIDIS, Grigorios
IPC分类号： C07D211/86 , C07D239/22 , A61K31/4412 , A61K31/505 , A61P29/00
CPC分类号： C07D213/64 , C07D213/82 , C07D239/557 , C07D241/24 , C07D413/12
摘要： There are provided novel compounds of formula (I) wherein R1, R4, R5, G1, G2, X, L, Y1, Y2 and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
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