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公开(公告)号：EP2235037A1
公开(公告)日：2010-10-06
申请号：EP08863416.7
申请日：2008-12-18
申请人： AstraZeneca AB
发明人： BLADH, Håkan , EDMAN, Karl , HANSSON, Thomas , LAWITZ, Karolina , LEPISTÖ, Matti , MUSSIE, Tesfaledet
CPC分类号： C07J71/00
摘要： The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2 , X3, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.
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公开(公告)号：EP3160948A1
公开(公告)日：2017-05-03
申请号：EP15736015.7
申请日：2015-06-26
申请人： Astrazeneca AB
发明人： O'MAHONY, Gavin , KOSSENJANS, Michael , EDMAN, Karl , KAJANUS, Johan , HOGNER, Carl Anders , CORNWALL, Philip , TURNER, Andrew
IPC分类号： C07D265/36 , A61K31/538 , A61P9/12
CPC分类号： C07D413/10 , C07D265/36 , C07D413/06
摘要： Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
摘要翻译： 公开了作为盐皮质激素（MR）受体调节剂的式（I）的苯并恶嗪酮酰胺的某些衍生物或其药学可接受的盐，其可以减少内皮中的氧化应激并因此改善血管功能，涉及其潜在治疗用途的方法， 含有它们的药物组合物以及制备这些化合物的方法。
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公开(公告)号：EP3160948B1
公开(公告)日：2018-10-24
申请号：EP15736015.7
申请日：2015-06-26
申请人： Astrazeneca AB
发明人： O'MAHONY, Gavin , KOSSENJANS, Michael , EDMAN, Karl , KAJANUS, Johan , HOGNER, Carl Anders , CORNWALL, Philip , TURNER, Andrew
IPC分类号： C07D265/36 , A61K31/538 , A61P9/12
CPC分类号： C07D413/10 , C07D265/36 , C07D413/06
摘要： Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
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4.发明授权INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS 有权INDAZOLYLAMIDDERIVATE用于治疗由糖皮质激素介导的疾病
公开(公告)号：EP2102169B1
公开(公告)日：2012-06-20
申请号：EP07852132.5
申请日：2007-12-20
发明人： BERGER, Markus , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HANSSON, Thomas , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , McKERRECHER, Darren , MUNCK AF ROSENSCHÖLD, Magnus , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla , EDMAN, Karl
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4709 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
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5.发明公开PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES 有权BENZODIOXINYL-SUBSTITUIERTE INDAZOLDERIVATE
公开(公告)号：EP2291369A1
公开(公告)日：2011-03-09
申请号：EP09750866.7
申请日：2009-05-20
申请人： AstraZeneca AB
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula la: (Ia) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：EP3197878B1
公开(公告)日：2019-07-24
申请号：EP15775130.6
申请日：2015-09-23
申请人： Astrazeneca AB
发明人： RIPA, Lena, Elisabeth , LAWITZ, Karolina , LEPISTÖ, Matti Juhani , HEMMERLING, Martin , EDMAN, Karl , LLINAS, Antonio
IPC分类号： C07D401/04 , A61K31/4439 , A61P19/02
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公开(公告)号：EP2291369B1
公开(公告)日：2015-11-04
申请号：EP09750866.7
申请日：2009-05-20
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
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8.发明公开INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS 有权INDAZOLYLAMIDDERIVATE用于治疗由糖皮质激素介导的疾病
公开(公告)号：EP2102169A1
公开(公告)日：2009-09-23
申请号：EP07852132.5
申请日：2007-12-20
发明人： BERGER, Markus , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HANSSON, Thomas , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , McKERRECHER, Darren , MUNCK AF ROSENSCHÖLD, Magnus , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla , EDMAN, Karl
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4709 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
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