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公开(公告)号：EP3363807A1
公开(公告)日：2018-08-22
申请号：EP17203302.9
申请日：2007-06-21
申请人： AstraZeneca AB
发明人： GOUGOUTAS, Jack Z. , NIRSCHL, Alexandra A. , SINGH, Janak , DIMARCO, John D. , LOBINGER, Hildegard , RAMAKRISHNAN, Srividya , DESHPANDE, Prashant P. , BIEN, Jeffrey T. , LAI, Chiajen , WANG, Chenchi , RIEBEL, Peter , GROSSO, John Anthony
摘要： The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a crystalline (2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl] -6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol (S)-propylene glycol solvate (compound Ia) as SGLT2 inhibitor for treating diabetes.
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2.发明授权(2S,3R,4S,5S,6R)-2-[4-CHLORO-3-(4-ETHOXY-BENZYL)-PHENYL]-6-HYDROXYMETHYL-2-METHOXY-TETRAHYDRO-PYRAN-3,4,5-TRIOL PROPYLENE GLYCOL SOLVATE AS SGT2 INHIBITOR FOR THE TREATMENT OF DIABETES 有权（2S，3R，4S，5S，6R）-2- [4-氯-3-（4-乙氧基 - 苄基） - 苯基] -6-羟基甲基-2-甲氧基 - 四氢 - 吡喃-3,4,5- TRIOL PROPYLENE GLYCOL SOLVATE作为SGT2抑制剂用于治疗糖尿病
公开(公告)号：EP3045466B1
公开(公告)日：2017-12-06
申请号：EP15181545.3
申请日：2007-06-21
申请人： AstraZeneca AB
发明人： GOUGOUTAS, Jack Z. , NIRSCHL, Alexandra A. , SINGH, Janak , DIMARCO, John D. , LOBINGER, Hildegard , RAMAKRISHNAN, Srividya , DESHPANDE, Prashant P. , BIEN, Jeffrey T. , LAI, Chiajen , WANG, Chenchi , RIEBEL, Peter , GROSSO, John Anthony
IPC分类号： C07H7/04 , C07H15/207 , A61K31/7034 , A61K45/06 , A61P3/10
CPC分类号： C07H15/207 , A61K31/7034 , A61K45/06 , A61P3/10 , C07H7/04
摘要： The present invention relates to physical crystal structures of a compound of the formula I: wherein R 1 , R 2 , R 2a , R 3 and R 4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
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公开(公告)号：EP3363807B1
公开(公告)日：2019-11-13
申请号：EP17203302.9
申请日：2007-06-21
申请人： AstraZeneca AB
发明人： GOUGOUTAS, Jack Z. , NIRSCHL, Alexandra A. , SINGH, Janak , DIMARCO, John D. , LOBINGER, Hildegard , RAMAKRISHNAN, Srividya , DESHPANDE, Prashant P. , BIEN, Jeffrey T. , LAI, Chiajen , WANG, Chenchi , RIEBEL, Peter , GROSSO, John Anthony
IPC分类号： C07H7/04 , C07H15/207 , A61K31/70 , A61K31/7034 , A61K45/06 , A61P3/10
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4.发明公开(2S,3R,4S,5S,6R)-2-[4-CHLORO-3-(4-ETHOXY-BENZYL)-PHENYL]-6-HYDROXYMETHYL-2-METHOXY-TETRAHYDRO-PYRAN-3,4,5-TRIOL PROPYLENE GLYCOL SOLVATE AS SGT2 INHIBITOR FOR THE TREATMENT OF DIABETES 有权（2S，3R，4S，5S，6R）-2- [4-氯-3-（4-乙氧基 - 苄基） - 苯基] -6-羟基甲基-2-甲氧基 - 四氢 - 吡喃-3,4,5- TRIOL丙戊酸溶液ALS SGT2抑制剂ZUR BEHANDLUNG VON糖尿病
公开(公告)号：EP3045466A1
公开(公告)日：2016-07-20
申请号：EP15181545.3
申请日：2007-06-21
申请人： AstraZeneca AB
发明人： GOUGOUTAS, Jack Z. , NIRSCHL, Alexandra A. , SINGH, Janak , DIMARCO, John D. , LOBINGER, Hildegard , RAMAKRISHNAN, Srividya , DESHPANDE, Prashant P. , BIEN, Jeffrey T. , LAI, Chiajen , WANG, Chenchi , RIEBEL, Peter , GROSSO, John Anthony
IPC分类号： C07H7/04 , C07H15/207 , A61K31/7034 , A61K45/06 , A61P3/10
CPC分类号： C07H15/207 , A61K31/7034 , A61K45/06 , A61P3/10 , C07H7/04
摘要： The present invention relates to the propylene glycol solvate of (2S,3R,4S,5S,6R)-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl] -6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4,5-triol (formula I):
as SGT2 inhibitor for the treatment of diabetes.摘要翻译： 本发明涉及（2S，3R，4S，5S，6R）-2- [4-氯-3-（4-乙氧基 - 苄基） - 苯基] -6-羟基甲基-2-甲氧基 - 四氢 - 吡喃-3,4,5-三醇（式I）：作为治疗糖尿病的SGT2抑制剂。
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5.发明授权CRYSTALLINE SOLVATES OF (1S)-1,5-ANHYDRO-1-C-(3-((PHENYL) METHYL) PHENYL)-D-GLUCITOL DERIVATIVES WITH ALCOHOLS AS SGLT2 INHIBITORS FOR THE TREATMENT OF DIABETES 有权（1S）-1,5-壬基-1-C-（3 - （（苯基）甲基）苯基）-D-葡萄糖醇衍生物麻醉碱性醇ALS SGLT2-抑制剂ZUR BEHANDLUNG VON糖尿病
公开(公告)号：EP2069374B1
公开(公告)日：2014-07-30
申请号：EP07784499.1
申请日：2007-06-21
申请人： AstraZeneca AB
发明人： GOUGOUTAS, Jack, Z. , LOBINGER, Hildegard , RAMAKRISHNAN, Srividya , DESHPANDE, Prashant, P. , BIEN, Jeffrey, T. , LAI, Chiajen , WANG, Chenchi , RIEBEL, Peter , GROSSO, John, Anthony , NIRSCHL, Alexandra, A. , SINGH, Janak , DIMARCO, John, D.
CPC分类号： C07H15/207 , A61K31/7034 , A61K45/06 , A61P3/10 , C07H7/04
摘要： The present invention relates to physical crystal structures of a compound of the formula I: wherein R 1 , R 2 , R 2a , R 3 and R 4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
摘要翻译： 本发明涉及式I化合物的物理结晶结构：其中R 1，R 2，R 2a，R 3和R 4如本文所定义，特别是含有化合物I或II结构的药物组合物，制备方法 相同的，制备相同的中间体，以及使用这种结构治疗糖尿病等疾病的方法。
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