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1.发明授权
公开(公告)号：EP2097384B1
公开(公告)日：2012-09-12
申请号：EP07835228.3
申请日：2007-11-22
发明人： BERGER, Markus , BERGSTRÖM, Lena , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , MCKERRECHER, Darren , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla
IPC分类号： C07D231/56 , A61K31/416 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07D401/04 , C07D401/14
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
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2.发明授权INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS 有权INDAZOLYLAMIDDERIVATE用于治疗由糖皮质激素介导的疾病
公开(公告)号：EP2102169B1
公开(公告)日：2012-06-20
申请号：EP07852132.5
申请日：2007-12-20
发明人： BERGER, Markus , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HANSSON, Thomas , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , McKERRECHER, Darren , MUNCK AF ROSENSCHÖLD, Magnus , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla , EDMAN, Karl
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4709 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
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3.发明授权NOVEL DERIVATIVES OF STEROIDAL [3,2-C] PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY 有权具有糖皮质激素活性的甾体[3,2-C]吡唑类化合物的新衍生物
公开(公告)号：EP2414377B1
公开(公告)日：2016-01-06
申请号：EP10759128.1
申请日：2010-04-01
申请人： AstraZeneca AB
发明人： BLADH, Håkan , BURKAMP, Frank , GABOS, Balint , HANSEN, Peter
CPC分类号： A61K31/58 , C07J71/0047
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公开(公告)号：EP1831199B1
公开(公告)日：2012-02-15
申请号：EP05815745.4
申请日：2005-12-14
申请人： AstraZeneca AB
发明人： GABOS, Balint , LUNDKVIST, Michael , MUNCK AF ROSENSCHÖLD, Magnus , SHAMOVSKY, Igor , ZLATOIDSKY, Pavol
IPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61P11/06 , A61P19/02 , A61P35/00 , A61P9/10 , C07D471/04
CPC分类号： C07D401/14 , C07D471/04
摘要： The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
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公开(公告)号：EP1794147A1
公开(公告)日：2007-06-13
申请号：EP05755334.9
申请日：2005-07-04
申请人： AstraZeneca AB
发明人： GABOS, Balint , RIPA, Lena , STENVALL, Kristina
IPC分类号： C07D401/14 , C07D233/72 , A61K31/4166 , A61K31/4439 , A61K31/454 , A61P11/06
CPC分类号： C07D401/14
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.
摘要翻译： 本发明提供了式（I）的化合物：其中R 1和R 2如说明书中所定义; 制备过程; 含有它们的药物组合物 制备药物组合物的方法; 和它们在治疗中的用途。
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公开(公告)号：EP2097406B1
公开(公告)日：2011-07-20
申请号：EP07824738.4
申请日：2007-11-28
申请人： AstraZeneca AB
IPC分类号： C07D403/12 , C07D239/34 , A61K31/506 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02
CPC分类号： C07D403/12 , C07D239/34
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
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7.发明授权
公开(公告)号：EP1778673B1
公开(公告)日：2009-11-11
申请号：EP05756403.1
申请日：2005-07-04
申请人： AstraZeneca AB
发明人： GABOS, Balint , RIPA, Lena , STENVALL, Kristina
IPC分类号： C07D401/14 , A61K31/506 , A61P11/00
CPC分类号： C07D401/14
摘要： The invention provides compounds of formula (I), wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.
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8.发明公开NOVEL DERIVATIVES OF STEROIDALÝ3,2-C¨PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY 有权具有糖皮质激素活性的类甾体3,2-吡唑类化合物的新衍生物
公开(公告)号：EP2414377A1
公开(公告)日：2012-02-08
申请号：EP10759128.1
申请日：2010-04-01
申请人： AstraZeneca AB
发明人： BLADH, Håkan , BURKAMP, Frank , GABOS, Balint , HANSEN, Peter
CPC分类号： A61K31/58 , C07J71/0047
摘要： The present invention provides named compounds of formula (I), and pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了命名的式（I）化合物和含有它们的药物组合物及其在治疗中的用途。
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9.发明公开NOVEL AMIDE DERIVATIVES OF STEROIDALÝ3,2-C¨PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY 审中-公开具有糖皮质激素活性的甾体2,3,2-吡唑类化合物的新酰胺衍生物
公开(公告)号：EP2414375A1
公开(公告)日：2012-02-08
申请号：EP10759125.7
申请日：2010-03-31
申请人： AstraZeneca AB
CPC分类号： C07J71/0047 , A61K31/58
摘要： The present invention provides compounds of formula (I) wherein n, R
1 , R
2 , X
1 , X
2 , X
3 , X
4, X
5 , R
3a , R
3b , R
4 , R
5 and R
6 are defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.摘要翻译： 本发明提供了式（I）的化合物，其中n，R 1，R 2，X 1，X 2，X 3，X 4，X 5，R 3a，R 3b，R 4，R 5和R 6被定义 在说明书中，它们的制备方法，含有它们的药物组合物以及它们在治疗中的用途。
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公开(公告)号：EP2097406A1
公开(公告)日：2009-09-09
申请号：EP07824738.4
申请日：2007-11-28
申请人： AstraZeneca AB
IPC分类号： C07D403/12 , C07D239/34 , A61K31/506 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02
CPC分类号： C07D403/12 , C07D239/34
摘要： The invention provides compounds of formula (I): wherein R1 and R2 are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
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