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公开(公告)号：EP1831199B1
公开(公告)日：2012-02-15
申请号：EP05815745.4
申请日：2005-12-14
申请人： AstraZeneca AB
发明人： GABOS, Balint , LUNDKVIST, Michael , MUNCK AF ROSENSCHÖLD, Magnus , SHAMOVSKY, Igor , ZLATOIDSKY, Pavol
IPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61P11/06 , A61P19/02 , A61P35/00 , A61P9/10 , C07D471/04
CPC分类号： C07D401/14 , C07D471/04
摘要： The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
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2.发明公开NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES 审中-公开新DIAZASPIROALKANE和它们在疾病治疗的介导CCR8
公开(公告)号：EP1678178A1
公开(公告)日：2006-07-12
申请号：EP04793824.6
申请日：2004-10-21
申请人： AstraZeneca AB
发明人： BLADH, Hakan , CONNOLLY, Stephen, AstraZeneca R & D Charnwood , DYKE, Hazel Joan, Argenta Discovery Ltd. , LISIUS, Annea , PRICE, Stephen, Argenta Discovery Ltd. , SHAMOVSKY, Igor , VAN DEN HEUVEL, Marco, Argenta Discovery Ltd.
IPC分类号： C07D471/10 , A61K31/438 , A61P11/06
CPC分类号： C07D471/10
摘要： The invention provides compounds of general formula. wherein A, B, W, X, Y, Z, D, E, R1 and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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3.发明授权3,4-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF ENAC MEDIATED DISEASES 有权3,4-二氨基-6-氯吡嗪-2-羧酰胺类化合物用于治疗ENAC介导的疾病
公开(公告)号：EP3119752B1
公开(公告)日：2018-05-16
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
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公开(公告)号：EP1831199A1
公开(公告)日：2007-09-12
申请号：EP05815745.4
申请日：2005-12-14
申请人： AstraZeneca AB
发明人： GABOS, Balint , LUNDKVIST, Michael , MUNCK AF ROSENSCHÖLD, Magnus , SHAMOVSKY, Igor , ZLATOIDSKY, Pavol
IPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61P11/06 , A61P19/02 , A61P35/00 , A61P9/10 , C07D471/04
CPC分类号： C07D401/14 , C07D471/04
摘要： The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
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公开(公告)号：EP1831196A1
公开(公告)日：2007-09-12
申请号：EP05815746.2
申请日：2005-12-14
申请人： AstraZeneca AB
发明人： GABOS, Balint , LUNDKVIST, Michael , MUNCK AF ROSENSCHÖLD, Magnus , SHAMOVSKY, Igor , ZLATOIDSKY, Pavol
IPC分类号： C07D401/12 , A61K31/4375 , A61K31/4725 , A61K31/506 , A61P11/06 , A61P19/02 , A61P35/00 , A61P9/10 , C07D401/14 , C07D471/04
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The invention provides compounds of formula (I): wherein R1, R2, A, A1 and B are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy. The compounds are useful as MMP inhibitors.
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公开(公告)号：EP3119752A1
公开(公告)日：2017-01-25
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
摘要翻译： 本发明提供式（I）的化合物或其药学上可接受的盐; 制备这种化合物的方法; 以及在治疗ENaC介导的疾病状态（例如哮喘，CF或COPD）中使用这种化合物。
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7.发明公开NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA 审中-公开NEW FOR治疗哮喘和COPD的适当的1-苄基-4-哌啶
公开(公告)号：EP1945613A1
公开(公告)日：2008-07-23
申请号：EP06812951.9
申请日：2006-10-31
申请人： AstraZeneca AB
发明人： HEMMERLING, Martin , HOSSAIN, Nafizal , IVANOVA, Svetlana , MUSSIE, Tesfaledet , SHAMOVSKY, Igor , SJÖHOLM Timèn, Åsa
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/454 , A61P11/00 , A61P11/06 , C07D401/12
CPC分类号： C07D211/58 , C07D211/72 , C07D401/12
摘要： The invention provides 1 -benzyl- 4 -piperidinamines of the general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory diseses such as chronic obstructive pulmonary disease and asthma. The compounds are inhibitors of the CCRl receptor.
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8.发明公开NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES 审中-公开新DIAZASPIROALKANE和它们在疾病治疗的介导CCR8
公开(公告)号：EP1926730A1
公开(公告)日：2008-06-04
申请号：EP06784143.7
申请日：2006-09-04
申请人： AstraZeneca AB
发明人： BÖRJESSON, Lena , CONNOLLY, Stephen , JOHANSSON, Henrik , KRISTOFFERSSON, Anna , LINNANEN, Tero , SHAMOVSKY, Igor , SKRINJAR, Marco
IPC分类号： C07D471/10 , A61K31/407 , A61K31/438 , A61P11/00 , A61P11/06 , C07D487/10
CPC分类号： C07D487/10 , C07D471/10
摘要： The invention provides compounds of general formula (I) wherein A, B, p, w, x, y, and z are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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