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公开(公告)号：EP3995477A1
公开(公告)日：2022-05-11
申请号：EP19936457.1
申请日：2019-07-02
发明人： HONG, Hao , LU, Jiangping , FENG, Xichun , SUN, Xingfang , ZHANG, Feng
IPC分类号： C07C2/86 , C07C13/04 , C07C245/16 , C07B37/02
摘要： The present disclosure discloses a method and a device for continuously synthesizing cyclopropane compounds. The method includes the following steps: continuously performing a synthetic reaction of a diazomethane precursor in a first reactor, the reaction product of the first reactor flowing into a separator for stratification, the organic phase obtained by stratification overflowing into a second reactor, continuously consuming the diazomethane precursor in a second reactor to prepare diazomethane and performing an electron-rich monoolefin cyclopropanation reaction in situ so as to obtain the cyclopropane compound. The technical solution of the present disclosure may be applied to achieve automatic control, decrease the transfer of high-risk materials, and prevent the risk of pipeline transfer of diazomethane solution, and effectively improve production safety. Moreover, the present disclosure provides a simple device to save equipment investment, and may safely and quantitatively achieve the production of diazomethane and the cyclopropanation reaction of olefins simultaneously.
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公开(公告)号：EP4036096A1
公开(公告)日：2022-08-03
申请号：EP19947330.7
申请日：2019-09-24
发明人： HONG, Hao , LU, Jiangping , FENG, Xichun , SUN, Xingfang , LIANG, Yong
摘要： The invention provides a continuous preparation method for benzylzinc halide and a derivative thereof. The continuous preparation method uses a continuous reactor for reaction of direct inserting a zinc atom into a carbon-halogen bond, wherein the continuous reactor comprises a heating section and a cooling section that are connected to each other, the cooling section is located above the heating section, and the cooling section has a product overflow port, the continuous preparation method comprising: respectively continuously feeding a liquid reaction material and a zinc powder to the heating section, the zinc powder being continuously fed into the heating section from an over part of the heating section, the liquid reaction material being fed into the heating section from a lower part of the heating section, subjecting same to a direct the zinc atom insert into carbon-halogen bond reaction to obtain a product system, and allowing the product system to discharge from the continuous reactor via the product overflow port, wherein the liquid reaction materials comprise a halide, and the halide has structural formula I
According to the continuous preparation method, zinc powder does not accumulate in the continuous reactor, thus avoiding the risk of spraying material and facilitating the application of the continuous preparation method in large-scale production.
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