公开(公告)号：EP3974411A1

公开(公告)日：2022-03-30

申请号：EP19930141.7

申请日：2019-05-21

申请人： Asymchem Laboratories (Tianjin) Co., Ltd.

发明人： HONG, Hao ,  LU, Jiangping ,  ZHANG, Enxuan ,  SHEN, Wei ,  YAN, Honglei ,  ZHANG, Zhen

IPC分类号： C07C245/16 ,  C07C245/14

摘要： Provided is a preparation process of diazomethane. The preparation process includes: step S1, taking N-methylurea as a raw material to continuously prepare, in a continuous reactor, a first product system containing N-methyl-N-nitrosourea; step S2, performing continuous extraction and continuous back-extraction on the first product system to obtain an N-methyl-N-nitrosourea solution; step S3, enabling the N-methyl-N-nitrosourea solution to continuously react with an alkaline solution in a continuous reactor to obtain a second product system containing the diazomethane; and step S4, performing continuously liquid separation, water freezing and removal on the second product system, to obtain the diazomethane. N-methylurea is used as a raw material, full continuous reaction and post-treatment are used to obtain 2-methyltetrahydrofuran solution of MNU, and then the full continuous reaction and post-treatment are directly used again to obtain anhydrous diazomethane solution, a freezing process is used to remove water, an expensive semipermeable membrane or a liquid-liquid separator is avoided from being used, so the cost is lower.