公开(公告)号：EP3315491A1

公开(公告)日：2018-05-02

申请号：EP17197122.9

申请日：2017-10-18

申请人： Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen

发明人： Königs, Rene ,  Hock, Katharina Julia ,  Mertens, Lukas

IPC分类号： C07D231/08 ,  C07D231/12 ,  C07D231/14 ,  C07D487/04 ,  C07C245/14 ,  C07D213/26 ,  C07C17/32 ,  C07C22/08

CPC分类号： C07C249/00 ,  C07C17/32 ,  C07C22/08 ,  C07C245/14 ,  C07C2601/02 ,  C07C2603/08 ,  C07D213/26 ,  C07D231/08 ,  C07D231/12 ,  C07D231/14 ,  C07D487/04

摘要： Die Erfindung betrifft ein Verfahren zur Herstellung eines fluorierten Diazoalkans, wobei es sich bei dem Verfahren um ein kontinuierliches Verfahren handelt und ein β,β-Difluoralkylamin mit einem organischen Nitrit in einem Reaktor umgesetzt wird, wobei das β,β-Difluoralkylamin und das organische Nitrit in getrennten Gefäßen vorgelegt werden, sowie die Verwendung des Verfahren zur Herstellung einer fluoralkyl-substituierten Verbindung.

摘要翻译： 本发明涉及一种方法，用于生产氟化重氮烷，其特征在于，它是在该过程是连续的过程和一个β，β-Difluoralkylamin与在反应器中的有机亚硝酸酯，其中，所述β，β-Difluoralkylamin和有机亚硝酸酯反应 呈现在分开的容器中，以及使用生产氟代烷基取代的化合物的方法。

公开(公告)号：EP2635548B8

公开(公告)日：2015-02-18

申请号：EP11778584.0

申请日：2011-11-01

申请人： DPx Fine Chemicals Austria GmbH & Co KG

发明人： REINTJENS, Rafael, Wilhelmus, Elisabeth, Ghislain ,  DIELEMANS, Hubertus, Johannes, Adrianus ,  THATHAGAR, Mehul ,  KONINGS, Jeroen, Hubertina, Gerardus ,  POECHLAUER, Peter

IPC分类号： C07C67/00 ,  C07C69/78 ,  C07C245/14 ,  C07C245/16

CPC分类号： C07C245/16 ,  C07C67/00 ,  C07C245/14 ,  C07D231/06 ,  C07C69/78

公开(公告)号：EP2185565B1

公开(公告)日：2014-08-13

申请号：EP08805961.3

申请日：2008-06-09

申请人： BIOMERIEUX ,  CNRS ,  Université de Strasbourg

发明人： LAURENT, Alain ,  LAAYOUN, Ali ,  KOTERA, Mitsuharu

IPC分类号： C07D495/04 ,  G01N33/58 ,  C07D333/24 ,  C07D233/32 ,  C07C245/14 ,  C12Q1/68

CPC分类号： C07D495/04 ,  Y10T436/13

公开(公告)号：EP2054465B1

公开(公告)日：2012-07-11

申请号：EP07789289.1

申请日：2007-08-22

申请人： ISIS INNOVATION LIMITED

发明人： MOLONEY, Mark ,  GRIFFITHS, Jon-Paul

IPC分类号： C08J7/12 ,  B05D5/10 ,  C03C17/28 ,  C09C1/00 ,  D06M13/00 ,  D06M13/03 ,  D06M13/11 ,  D06M13/288 ,  D06M13/338 ,  D06M13/322 ,  D21H25/02 ,  C07C241/02 ,  C07C245/14 ,  C07C243/18 ,  C07C249/16

CPC分类号： C08J7/12 ,  C01P2004/61 ,  C01P2004/64 ,  C03C17/28 ,  C07C245/12 ,  C07C245/20 ,  C07F9/3882 ,  C09C3/08 ,  C09C3/10 ,  D06M13/03 ,  D06M13/11 ,  D06M13/288 ,  D06M13/338

摘要： A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (I): whose substituent groups are defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -LB-WB; and (b) either: (i) when WA or WB comprises an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, thereby yielding said substrate having an adhesive surface; or (ii) when WA or WB comprises a group which is a precursor of an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, and (c) converting said group which is a precursor into an adhesive functional group thereby yielding said substrate having an adhesive surface. The invention further relates to carbene precursor compounds for use in the process, substrates produced by the process and to processes for preparing certain precursor compounds.

公开(公告)号：EP1383732B1

公开(公告)日：2010-02-17

申请号：EP02740788.1

申请日：2002-05-03

申请人： BIO MERIEUX ,  UNIVERSITE JOSEPH FOURIER (GRENOBLE 1) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BOURGET, Cécile ,  LHOMME, Jean ,  LAAYOUN, Ali ,  KOTERA, Mitsuharu ,  TREVISIOL, Emmanuelle ,  MENOU, Lionel ,  BERNAL MENDEZ, Eloy

IPC分类号： C07C245/14 ,  C07C245/18 ,  C07D209/14 ,  C07D495/04 ,  C07D311/82 ,  C12Q1/68

CPC分类号： C07D209/08 ,  C07C245/14 ,  C07C245/18 ,  C07D311/90 ,  C07D495/04

公开(公告)号：EP1273568A2

公开(公告)日：2003-01-08

申请号：EP02014698.1

申请日：2002-07-03

申请人： CONSIGLIO NAZIONALE DELLE RICERCHE ,  UNIVERSITA' DEGLI STUDI DI UDINE

发明人： Verardo, Giancarlo ,  Giumanini, Angelo ,  Zappala', Antonio ,  Gorassini, Andrea

IPC分类号： C07C245/14 ,  C07D295/12 ,  C07C271/20 ,  C07C281/02 ,  D21H25/18

CPC分类号： C07D295/13 ,  C07C245/14 ,  C07C271/20 ,  C07C281/02 ,  D21H25/18

摘要： Novel diazo derivatives useful for the deacidification of paper material and the process for their preparation comprising three steps starting from an amine and ethyl chlorocarbonate, are described.

摘要翻译： 描述了用于纸材脱酸的新型重氮衍生物及其制备方法，包括从胺和氯甲酸乙酯开始的三个步骤。

公开(公告)号：EP0685459A1

公开(公告)日：1995-12-06

申请号：EP95902975.2

申请日：1994-12-16

申请人： OTSUKA KAGAKU KABUSHIKI KAISHA

发明人： KAWAHARA, Ichiro ,  WADA, Isao ,  SASAOKA, Michio 1-16, Nakanokoshi Aza Nakase

IPC分类号： C07C245/16 ,  C07B61/00 ,  B01J31/02 ,  B01J31/26 ,  C07C245/14

CPC分类号： C07C245/14

摘要： A process for producing a diazomethane derivative by oxidizing a hydrazone derivative in a two-phase system containing: a) an aqueous solution of a mixture of a caustic alkali and an alkali metal hypochlorite in respective concentrations of 4-14 w/w % and 3-10 w/w % based on the total weight of the solution; b) a hydrophobic organic solvent; c) an inorganic iodine compound, and d) a phase-transfer catalyst.

摘要翻译： 通过在两相体系中氧化腙衍生物来制备重氮甲烷衍生物的方法，其包含：a）苛性碱和碱金属次氯酸盐的混合物的水溶液，其浓度分别为4-14w / w％和3 -10w / w％，基于溶液的总重量; b）疏水性有机溶剂; c）无机碘化合物，和d）相转移催化剂。

公开(公告)号：EP0412457A1

公开(公告)日：1991-02-13

申请号：EP90114974.0

申请日：1990-08-03

申请人： TOSOH CORPORATION

发明人： Todoko, Masaaki ,  Taniguchi, Takashi ,  Seita, Toru ,  Sato, Shinji ,  Shibata, Katuya,

IPC分类号： G03F7/004 ,  G03F7/022 ,  C07F7/18 ,  C07C229/12 ,  C07C245/14 ,  C07C245/18 ,  C07C309/76

CPC分类号： C07F7/1852 ,  C07C229/12 ,  C07C245/14 ,  C07F7/1844 ,  G03F7/0045 ,  G03F7/0226 ,  Y10S430/115

摘要： A positive resist composition comprising an aromatic group-containing alkali-soluble resin and a compound having an ammonium salt as skeleton, as the main components.

摘要翻译： 作为主要成分，含有含芳香族基团的碱溶性树脂和具有铵盐作为骨架的化合物的正性抗蚀剂组合物。

公开(公告)号：EP3974411A1

公开(公告)日：2022-03-30

申请号：EP19930141.7

申请日：2019-05-21

申请人： Asymchem Laboratories (Tianjin) Co., Ltd.

发明人： HONG, Hao ,  LU, Jiangping ,  ZHANG, Enxuan ,  SHEN, Wei ,  YAN, Honglei ,  ZHANG, Zhen

IPC分类号： C07C245/16 ,  C07C245/14

摘要： Provided is a preparation process of diazomethane. The preparation process includes: step S1, taking N-methylurea as a raw material to continuously prepare, in a continuous reactor, a first product system containing N-methyl-N-nitrosourea; step S2, performing continuous extraction and continuous back-extraction on the first product system to obtain an N-methyl-N-nitrosourea solution; step S3, enabling the N-methyl-N-nitrosourea solution to continuously react with an alkaline solution in a continuous reactor to obtain a second product system containing the diazomethane; and step S4, performing continuously liquid separation, water freezing and removal on the second product system, to obtain the diazomethane. N-methylurea is used as a raw material, full continuous reaction and post-treatment are used to obtain 2-methyltetrahydrofuran solution of MNU, and then the full continuous reaction and post-treatment are directly used again to obtain anhydrous diazomethane solution, a freezing process is used to remove water, an expensive semipermeable membrane or a liquid-liquid separator is avoided from being used, so the cost is lower.

公开(公告)号：EP0910561B1

公开(公告)日：2004-04-07

申请号：EP97931457.2

申请日：1997-06-26

申请人： The Scripps Research Institute

发明人： LERNER, Richard, A. ,  WONG, Chi-Huey ,  BOGER, Dale, L. ,  HENRIKSEN, Steven, J.

IPC分类号： C07C259/06 ,  C07C45/45 ,  C07C47/21 ,  C07C49/227 ,  C07C59/42 ,  C07C69/716 ,  C07C69/738 ,  C07C233/08 ,  C07C233/09 ,  C07C235/28 ,  C07C235/76 ,  C07C243/30 ,  C07C245/14 ,  A61K31/12 ,  A61K31/15 ,  A61K31/16 ,  A61K31/23 ,  A61K31/655

CPC分类号： A61K31/08 ,  A61K31/11 ,  A61K31/12 ,  A61K31/121 ,  A61K31/15 ,  A61K31/16 ,  A61K31/201 ,  A61K31/23 ,  A61K31/231 ,  A61K31/655 ,  C07C45/45 ,  C07C45/63 ,  C07C47/21 ,  C07C49/227 ,  C07C59/42 ,  C07C69/716 ,  C07C69/738 ,  C07C233/09 ,  C07C235/28 ,  C07C235/76 ,  C07C243/30 ,  C07C245/14 ,  C07C259/06

摘要： Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly forming a (thio) hemiacetal or (thio) hemiketal to mimic the transition state of a serine or cysteine protease catalyzed reaction. In particular, the tight binding α-keto ethyl ester 8 (1.4 nM) and the trifluoromethyl ketone inhibitor 12 (1.2 nM) were found to have exceptional inhibitory activity. In addition to the inhibitory activity, some of the inhibitors displayed agonist activity which resulted in the induction of sleep in laboratory animals.