公开(公告)号：EP1108035A2

公开(公告)日：2001-06-20

申请号：EP99942661.2

申请日：1999-09-03

申请人： Aventis Pasteur Limited

发明人： GAJEWCZYK, Diane, M. ,  PERSSON, Roy ,  YAO, Fei-Long ,  CAO, Shi-Xian ,  KLEIN, Michel, H. ,  TARTAGLIA, James ,  MOINGEON, Phillipe ,  ROVINSKI, Benjamin

IPC分类号： C12N15/37 ,  C12N15/86 ,  C07K14/025 ,  A61K48/00

CPC分类号： A61B5/055 ,  A61B5/0263 ,  A61B5/029 ,  A61B5/41 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/53 ,  C07K14/005 ,  C12N2710/20022 ,  C12N2710/20043 ,  Y10S977/804 ,  Y10S977/904 ,  Y10S977/916 ,  Y10S977/924

摘要： Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.