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公开(公告)号:EP1728865A1
公开(公告)日:2006-12-06
申请号:EP06015673.4
申请日:1999-09-03
发明人: Gajewczyk, Diane M. , Persson, Roy , Yao, Fei-Long , Cao, Shi-Xian , Klein, Michel H. , Tartaglia, James , Moingeon, Philippe , Rovinski, Benjamin
IPC分类号: C12N15/37 , C12N15/86 , C07K14/025 , A61K48/00
CPC分类号: A61B5/055 , A61B5/0263 , A61B5/029 , A61B5/41 , A61K48/00 , A61K2039/51 , A61K2039/53 , C07K14/005 , C12N2710/20022 , C12N2710/20043 , Y10S977/804 , Y10S977/904 , Y10S977/916 , Y10S977/924
摘要: Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.
摘要翻译: 用于针对子宫颈癌的DNA免疫的载体包含编码与子宫颈癌相关的人乳头状瘤病毒(HPV)的菌株的E6和/或E7抗原的至少一种无毒T细胞表位的核酸分子,例如HPV- 16和可操作地偶联于核酸分子的启动子,用于在施用载体的宿主中表达核酸分子。