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1.发明授权CELLULES RECOMBINANTES DE LA LIGNEE MONOCYTE-MACROPHAGE POUR LA THERAPIE GENIQUE 失效用于基因治疗的单核细胞 - 巨噬细胞系的重组细胞
公开(公告)号：EP0719332B1
公开(公告)日：2004-07-28
申请号：EP94925523.6
申请日：1994-08-22
CPC分类号： C07K14/57 , A61K38/00 , A61K48/00 , C07K14/525
摘要： Cell compositions containing mononuclear phagocyte systems cells, and their use in cell therapy, e.g. adoptive immunotherapy, are disclosed.
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2.发明授权ASSOCIATION MEDICAMENTEUSE UTILE POUR LA TRANSFECTION ET L'EXPRESSION IN VIVO D'EXOGENES 失效医药组合物中的转染和外源性的体内表达
公开(公告)号：EP0809516B1
公开(公告)日：2001-08-22
申请号：EP96903080.8
申请日：1996-02-12
发明人： BACH, Jean-François , CHATENOUD, Lucienne , HADDADA, Hedi , LEE, Martin , PERRICAUDET, Michel , WEBB, Michelle
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343
摘要： A medicinal combination of at least one immunosuppressive agent and at least one recombinant adenovirus with a genome that includes a first recombinant DNA containing a therapeutic gene, and a second recombinant DNA containing an immunoprotective gene, for consecutive, intermittent and/or simultaneous use in in vivo and/or ex vivo exogenic transfections.
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3.发明授权
公开(公告)号：EP0687184B1
公开(公告)日：2002-07-24
申请号：EP94908383.6
申请日：1994-02-28
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343
摘要： The use of defective recombinant adenoviruses containing an inserted gene for preparing a pharmaceutical useful for treating eye diseases is disclosed.
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4.发明授权ADENOVIRUS VECTORS FOR THE TRANSFER OF FOREIGN GENES INTO CELLS OF THE CENTRAL NERVOUS SYSTEM, PARTICULARLY IN BRAIN 失效腺病毒载体外源基因在中枢神经系统的细胞的转移，特别是在脑
公开(公告)号：EP0669987B1
公开(公告)日：2008-08-13
申请号：EP93920753.6
申请日：1993-09-17
发明人： KAHN, Axel , MALLET, Jacques , PERRICAUDET, Michel , PESCHANSKI, Marc , ROBERT, Jean-Jacques , LE GAL LA SALLE, Gildas
CPC分类号： C12N15/86 , A61K38/185 , A61K38/44 , A61K38/47 , A61K48/00 , C12N9/0006 , C12N2710/10343 , C12N2830/008 , C12Y114/16002 , C12Y302/01051
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公开(公告)号：EP0730657B1
公开(公告)日：2008-04-30
申请号：EP95902161.9
申请日：1994-11-22
申请人： Aventis Pharma S.A. , INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BEUZARD, Yves , DANOS, Olivier , DESCAMPS, Vincent , HEARD, Jean-Michel , MOULLIER, Philippe , NAFFAKH, Nadia , PERRICAUDET, Michel , VAINCHENKER, William
CPC分类号： A61K38/1816 , A61K48/00 , C07K14/505
摘要： The present invention provides cell compositions for in vivo implantation, and designed for the sustained and controlled delivery of therapeutic substances.
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6.发明公开CELLULES RECOMBINANTES DE LA LIGNEE MONOCYTE-MACROPHAGE POUR LA THERAPIE GENIQUE 失效用于基因治疗的单核细胞 - 巨噬细胞系的重组细胞
公开(公告)号：EP0719332A1
公开(公告)日：1996-07-03
申请号：EP94925523.0
申请日：1994-08-22
CPC分类号： C07K14/57 , A61K38/00 , A61K48/00 , C07K14/525
摘要： Cell compositions containing mononuclear phagocyte systems cells, and their use in cell therapy, e.g. adoptive immunotherapy, are disclosed.
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7.发明公开ASSOCIATION MEDICAMENTEUSE UTILE POUR LA TRANSFECTION ET L'EXPRESSION IN VIVO D'EXOGENES 失效医药组合物中的转染和外源性的体内表达
公开(公告)号：EP0809516A1
公开(公告)日：1997-12-03
申请号：EP96903080.0
申请日：1996-02-12
发明人： BACH, Jean-François , CHATENOUD, Lucienne , HADDADA, Hedi , LEE, Martin , PERRICAUDET, Michel , WEBB, Michelle
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343
摘要： A medicinal combination of at least one immunosuppressive agent and at least one recombinant adenovirus with a genome that includes a first recombinant DNA containing a therapeutic gene, and a second recombinant DNA containing an immunoprotective gene, for consecutive, intermittent and/or simultaneous use in in vivo and/or ex vivo exogenic transfections.
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公开(公告)号：EP0730657A1
公开(公告)日：1996-09-11
申请号：EP95902161.0
申请日：1994-11-22
申请人： RHONE-POULENC RORER S.A. , INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BEUZARD, Yves , DANOS, Olivier , DESCAMPS, Vincent , HEARD, Jean-Michel , MOULLIER, Philippe , NAFFAKH, Nadia , PERRICAUDET, Michel , VAINCHENKER, William
IPC分类号： C12N15 , A61K9 , A61K35 , A61K38 , A61K39 , A61K48 , A61P5 , A61P7 , A61P13 , A61P15 , A61P43 , C07H21 , C07K14 , C12N5
CPC分类号： A61K38/1816 , A61K48/00 , C07K14/505
摘要： The present invention provides cell compositions for in vivo implantation, and designed for the sustained and controlled delivery of therapeutic substances.
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9.发明公开ADENOVIRUS VECTORS FOR THE TRANSFER OF FOREIGN GENES INTO CELLS OF THE CENTRAL NERVOUS SYSTEM, PARTICULARLY IN BRAIN 失效腺病毒载体外源基因在中枢神经系统的细胞的转移，特别是在大脑中。
公开(公告)号：EP0669987A1
公开(公告)日：1995-09-06
申请号：EP93920753.0
申请日：1993-09-17
发明人： KAHN, Axel , MALLET, Jacques , PERRICAUDET, Michel , PESCHANSKI, Marc , ROBERT, Jean-Jacques , LE GAL LA SALLE, Gildas
IPC分类号： C12N , C12N15 , A61K31 , A61K35 , A61K38 , A61K39 , A61K48 , A61P25 , C07H21 , C12N5 , C12N7 , C12N9 , C12P21 , C12Q1 , C12R1
CPC分类号： C12N15/86 , A61K38/185 , A61K38/44 , A61K38/47 , A61K48/00 , C12N9/0006 , C12N2710/10343 , C12N2830/008 , C12Y114/16002 , C12Y302/01051
摘要： The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression and/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, including the regions required for that adenovirus to penetrate into the cells normally infectable by that adenovirus and (ii) being inserted into said part of genome of an adenovirus under the control of a promoter, either present or also inserted into said genome part and operative in said cells. This recombinant vector finds particular use in the treatment of diseases of the central nervous system, also in gene therapy.
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10.发明公开ADENOVIRUS RECOMBINANTS ET LEUR UTILISATION EN THERAPIE GENIQUE POUR LE TRAITEMENT DES PATHOLOGIES OCULAIRES 失效重组ADENOVITEN和它们在基因治疗眼病治疗
公开(公告)号：EP0687184A1
公开(公告)日：1995-12-20
申请号：EP94908383.0
申请日：1994-02-28
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343
摘要： The use of defective recombinant adenoviruses containing an inserted gene for preparing a pharmaceutical useful for treating eye diseases is disclosed.
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