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公开(公告)号:EP4294927A2
公开(公告)日:2023-12-27
申请号:EP22713504.3
申请日:2022-03-10
申请人: Immunowake Inc.
发明人: WU, Ellen , WU, Xiaoyun , WAKEFIELD, John
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公开(公告)号:EP4058471A1
公开(公告)日:2022-09-21
申请号:EP20821517.8
申请日:2020-11-14
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公开(公告)号:EP3990491A1
公开(公告)日:2022-05-04
申请号:EP20727436.6
申请日:2020-04-24
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5.
公开(公告)号:EP3350318B1
公开(公告)日:2022-04-13
申请号:EP16847253.8
申请日:2016-09-14
发明人: BOSCH, Marnix, L.
IPC分类号: C12N5/0784 , C12N5/02 , C07K14/535 , C07K14/54 , C07K14/57 , C07K14/525 , A61K35/15 , G01N33/50 , G01N33/569 , G01N33/68
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公开(公告)号:EP3830115A1
公开(公告)日:2021-06-09
申请号:EP19845344.1
申请日:2019-07-29
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7.
公开(公告)号:EP3177636B1
公开(公告)日:2019-11-13
申请号:EP15752962.9
申请日:2015-07-31
申请人: Tenagro S.r.l.
IPC分类号: C07K14/47 , C07K1/30 , C07K14/495 , C07K14/525 , C07K14/55 , C07K14/57 , C07K14/79 , C07K1/34 , C07K1/36 , C07K14/475 , A61P17/02 , A23J1/20 , A23C9/20
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公开(公告)号:EP3502256A2
公开(公告)日:2019-06-26
申请号:EP18198570.6
申请日:2009-09-26
申请人: Tocagen Inc.
摘要: This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.
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9.
公开(公告)号:EP3350318A1
公开(公告)日:2018-07-25
申请号:EP16847253.8
申请日:2016-09-14
发明人: BOSCH, Marnix, L.
IPC分类号: C12N5/0784 , C12N5/02 , C07K14/535 , C07K14/54 , C07K14/57 , C07K14/525 , A61K35/15
CPC分类号: A61K35/15 , C07K14/525 , C07K14/5412 , C07K14/5421 , C07K14/5434 , C12N5/0639 , C12N2500/72 , C12N2501/22
摘要: The present disclosure provides partially mature and activated dendritic cells that produce levels of cytokines/chemokines, for example, one or any combination of, and/or all of IL-6, IL-8, IL-12 and/or TNFα, that are correlated with improved clinical outcomes, significantly increased survival times and significantly increased times to tumor or cancer recurrence. The determined threshold amounts of these cytokines can be used for (i) a immunotherapeutic potency test for activated dendritic cells, (ii) selecting responder patients, (iii) rejecting non-responder patients, and (iv) to screen for dendritic cell activation or maturation agents that can also induce the production of the threshold amount of the cytokines/chemokines.
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公开(公告)号:EP1499730B1
公开(公告)日:2013-10-02
申请号:EP03725526.2
申请日:2003-04-30
申请人: Molmed SpA
发明人: CORTI, Angelo , CURNIS, Flavio
IPC分类号: C07K14/525 , C07K14/57 , A61K47/48
CPC分类号: A61K49/0008 , A61K38/191 , A61K47/64 , A61K47/642 , A61K47/6813 , A61K47/6851 , A61K47/6887 , A61K51/0495 , C07K14/525 , C07K14/57 , C07K2319/01
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