-
1.发明授权SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) DIHYDROBENZOFURANS AND BENOZOPYRANS 有权取代（氨基亚氨基或氨甲基）二氢苯并呋喃和BENOZOPYRANE
公开(公告)号：EP1222182B1
公开(公告)日：2005-11-16
申请号：EP00968181.8
申请日：2000-08-12
IPC分类号： C07D307/81 , C07D307/78 , C07D307/77 , C07D409/14 , C07D407/12 , C07D473/04 , C07D409/12 , C07D405/12 , C07D405/14 , A61K31/343 , A61P7/02
CPC分类号： C07D405/12 , C07D307/81 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D471/04
摘要： This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans of formula (I) that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).
-
公开(公告)号：EP1051176B1
公开(公告)日：2006-11-22
申请号：EP99906684.8
申请日：1999-01-27
发明人： EWING, William, R. , BECKER, Michael, R. , CHOI-SLEDESKI, Yong, Mi , PAULS, Heinz, W. , HE, Wei , CONDON, Stephen, M. , DAVIS, Roderick, S. , HANNEY, Barbara, A. , SPADA, Alfred, P. , BURNS, Christopher, J. , JIANG, John, Z. , LI, Aiwen , MYERS, Michael, R. , LAU, Wan, F. , POLI, Gregory, B.
IPC分类号： C07D241/08 , A61K31/495
CPC分类号： C07D471/04 , C07D241/08 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D495/04
摘要： This invention is directed to oxoazaheterocyclyl compounds which inhibit factor Xa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of inhibiting factor Xa.
-
3.发明授权SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS 失效取代的（芳基，杂芳基，芳基甲基，杂芳OR）HYDROXAMISAEUREVERBINDUNGEN
公开(公告)号：EP0871439B1
公开(公告)日：2004-03-31
申请号：EP97901388.5
申请日：1997-01-02
发明人： GRONEBERG, Robert, D. , NEUENSCHWANDER, Kent, W. , DJURIC, Stevan, W. , MCGEEHAN, Gerard, M. , BURNS, Christopher, J. , CONDON, Steven, M. , MORRISSETTE, Matthew, M. , SALVINO, Joseph, M. , SCOTESE, Anthony, C. , ULLRICH, John, W.
IPC分类号： A61K31/19 , C07C259/04 , C07C317/44 , C07D317/62
CPC分类号： C07D209/48 , C07C259/06 , C07C317/44 , C07C323/60 , C07C2601/08 , C07D215/14 , C07D317/56 , C07D317/62
摘要： This invention is directed to compounds of formula (I), wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. Compounds within the scope of the present invention may also inhibit an MMP, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting MMPs, such disease states involve tissue breakdown and those associated with a physiologically detrimental excess of TNF. The present invention is therefore also directed to the pharmaceutical use of the compounds, pharmaceutical compositions containing the compounds, intermediates leading thereto and methods for the preparation of the compounds and their intermediates.
-
4.发明公开SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) DIHYDROBENZOFURANS AND BENOZOPYRANS 有权取代（氨基亚氨基或氨甲基）二氢苯并呋喃和BENOZOPYRANE
公开(公告)号：EP1222182A2
公开(公告)日：2002-07-17
申请号：EP00968181.8
申请日：2000-08-12
IPC分类号： C07D307/81 , C07D307/78 , C07D307/77 , C07D409/14 , C07D407/12 , C07D473/04 , C07D409/12 , C07D405/12 , C07D405/14 , A61K31/343 , A61P7/02
CPC分类号： C07D405/12 , C07D307/81 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D471/04
摘要： This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans of formula (I) that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).
-
-
-
搜索结果
4 条记录 (耗时 0.021 秒)
