-
公开(公告)号：EP1208097B1
公开(公告)日：2009-02-18
申请号：EP00951781.4
申请日：2000-07-26
发明人： EWING, William, R. , BECKER, Michael, R. , CHOI-SLEDESKI, Yong, Mi , PAULS, Heinz, W. , HE, Wei , CONDON, Stephen, M. , DAVIS, Roderick, S. , HANNEY, Barbara, A. , SPADA, Alfred, P. , BURNS, Christopher J. , JIANG, John, Z. , LI, Aiwen , MYERS, Michael, R. , LAU, Wan, F. , POLI, Gregory, B.
IPC分类号： C07D403/06 , C07D401/06 , C07D409/14 , C07D409/12 , C07D471/04 , C07D241/08 , C07D495/04 , C07D401/14 , C07D409/06 , C07D403/14 , C07D491/04 , C07D417/14 , A61K31/496 , A61P7/02
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D471/04 , Y02P20/582
摘要： This invention is directed to oxoazaheterocyclyl compounds which inhibit Factor Xa, to oxoazaheterocyclyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.
摘要翻译： 本发明涉及抑制因子Xa的氧代氮杂环基化合物，抑制因子Xa和因子IIa的氧代氮杂环基化合物，包含这些化合物的药物组合物，用于制备这些化合物的中间体，涉及直接抑制因子Xa和 同时直接抑制因子Xa和因子IIa的方法。
-
2.发明授权SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS 有权磺酸或磺酰基氨基-N-（杂芳烷基）-AZAHETEROZYKLYLAMIDVERBINDUNGEN
公开(公告)号：EP1086099B1
公开(公告)日：2005-09-28
申请号：EP99955266.4
申请日：1999-06-03
发明人： CHOI-SLEDESKI, Yong, Mi , PAULS, Heinz, W. , BARTON, Jeffrey, N. , EWING, William, R. , GREEN, Daniel, M. , BECKER, Michael, R. , GONG, Yong , LEVELL, Julian
IPC分类号： C07D471/02 , C07D217/00 , C07D215/00 , C07D401/00 , A61K31/44 , A61K31/47 , C07D495/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D409/14 , C07D471/04 , C07D491/04
CPC分类号： C07D409/14 , A61K31/00 , A61K31/4184 , A61K31/4365 , A61K31/437 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/519 , A61K45/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D471/04 , C07D491/04 , C07D495/04
-
公开(公告)号：EP1208097A2
公开(公告)日：2002-05-29
申请号：EP00951781.4
申请日：2000-07-26
发明人： EWING, William, R. , BECKER, Michael, R. , CHOI-SLEDESKI, Yong, Mi , PAULS, Heinz, W. , HE, Wei , CONDON, Stephen, M. , DAVIS, Roderick, S. , HANNEY, Barbara, A. , SPADA, Alfred, P. , BURNS, Christopher J. , JIANG, John, Z. , LI, Aiwen , MYERS, Michael, R. , LAU, Wan, F. , POLI, Gregory, B.
IPC分类号： C07D403/06 , C07D401/06 , C07D409/14 , C07D409/12 , C07D471/04 , C07D241/08 , C07D495/04 , C07D401/14 , C07D409/06 , C07D403/14 , C07D491/04 , C07D417/14 , A61K31/496 , A61P7/02
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D409/14 , C07D471/04 , Y02P20/582
摘要： This invention is directed to oxoazaheterocyclyl compounds which inhibit Factor Xa, to oxoazaheterocyclyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.
-
4.发明授权SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS 失效磺酸或磺酰基氨基的N-（杂芳烷基）-AZAHETEROCYCLYLAMID化合物
公开(公告)号：EP0944386B1
公开(公告)日：2002-09-18
申请号：EP97951573.1
申请日：1997-12-03
发明人： CHOI-SLEDESKI, Yong, Mi , PAULS, Henry, W. , BARTON, Jeffrey, N. , EWING, William, R. , GREEN, Daniel, M. , BECKER, Michael, R.
IPC分类号： A61K31/40 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/47 , A61K31/475 , A61K31/495 , C07D239/72 , C07D207/273 , C07D213/22 , C07D401/06
CPC分类号： C07D401/06 , A61K31/4184 , A61K31/4365 , A61K31/437 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61K31/519 , C07D403/06 , C07D409/14 , C07D471/04 , C07D491/04 , C07D495/04
-
5.发明授权SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON 有权取代的1H-吡咯并[3,2-B，3,2-C和2,3- C]吡啶-2-羧酰胺和相关类似物如酪蛋白激酶I-EPSILON的抑制剂
公开(公告)号：EP1747220B1
公开(公告)日：2009-04-15
申请号：EP04812567.8
申请日：2004-12-01
发明人： METZ, William, A. , HALLEY, Frank , DUTRUC-ROSSET, Gilles , CHOI-SLEDESKI, Yong, Mi , POLI, Gregory, B. , FINK, David, M. , DOERFLINGER, Gilles , HUANG, Bao-Guo , GELORMINI, Ann, Marie , GAMBOA, Juan, A. , GIOVANNI, Andrew , ROEHR, Joachim, E. , TSAY, Joseph, T. , CAMACHO, Fernando , HURST, William, J. , HARNISH, Stephen, W. , CHIANG, Yulin
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention discloses and claims substituted 1H-pyrrolo[3,2-b]pyridine-2-carboxamides, 1H-pyrrolo[3,2-c]pyridine-2-carboxamides and 1H-pyrrolo[2,3-c]pyridine-2-carboxamides (compounds of formula (I)) as inhibitors of human casein kinase I Epsilon, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
-
6.发明授权SUBSTITUTED (SULFINIC ACID, SULFONIC ACID, SULFONYLAMINO OR SULFINYLAMINO) N- (AMINOIMINOMETHYL)PHENYLALKYL -AZAHETEROCYCLYLAMIDE COMPOUNDS 失效取代的（（亚磺酸，磺酸，磺酰氨基或亚磺酰氨基）-N-（AMINOIMONOMETHYL）苯基烷基）-AZAHETEROCYCLYLAMID衍生物
公开(公告)号：EP0853618B1
公开(公告)日：2011-08-17
申请号：EP96919298.8
申请日：1996-06-07
发明人： EWING, William, R. , BECKER, Michael, R. , PAULS, Henry, W. , CHENEY, Daniel, L. , MASON, Jonathan, Stephen , SPADA, Alfred, P. , CHOI-SLEDESKI, Yong, Mi
IPC分类号： C07D207/26 , A61K31/40 , C07D407/12 , C07D401/12 , A61K31/47 , C07D409/14 , A61K31/44 , C07D207/14 , C07D207/40 , C07D211/76 , A61K31/445 , C07D223/12 , A61K31/55 , C07D409/12 , C07D403/12 , A61K31/505 , C07D205/085 , A61K31/395 , A61K31/415 , C07D401/06 , C07D409/06 , C07D407/06
CPC分类号： C07D207/273 , C07D205/085 , C07D207/14 , C07D207/416 , C07D211/76 , C07D223/12 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14
摘要： The compounds of formula (I) exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are inhibitors of the activity of Factor Xa. The present invention is directed to compounds of formula (I), compositions containing compounds of formula (I), and their use, which are for treating a patient suffering from, or subject to, physiological condition which can be ameliorated by the administration of an inhibitor of the activity of Factor Xa.
-
7.发明公开SUBSTITUTED 1H-PYRROLO 3,2-B, 3,2-C, AND 2,3-C¨PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON 有权取代的1H-吡咯并[3,2-B，3,2-C和2,3- C]吡啶-2-羧酰胺和相关类似物如酪蛋白激酶I-EPSILON的抑制剂
公开(公告)号：EP1747220A1
公开(公告)日：2007-01-31
申请号：EP04812567.8
申请日：2004-12-01
发明人： METZ, William, A. , HALLEY, Frank , DUTRUC-ROSSET, Gilles , CHOI-SLEDESKI, Yong, Mi , POLI, Gregory, B. , FINK, David, M. , DOERFLINGER, Gilles , HUANG, Bao-Guo , GELORMINI, Ann, Marie , GAMBOA, Juan, A. , GIOVANNI, Andrew , ROEHR, Joachim, E. , TSAY, Joseph, T. , CAMACHO, Fernando , HURST, William, J. , HARNISH, Stephen, W. , CHIANG, Yulin
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention discloses and claims substituted 1H-pyrrolo[3,2-b]pyridine-2-carboxamides, 1H-pyrrolo[3,2-c]pyridine-2-carboxamides and 1H-pyrrolo[2,3-c]pyridine-2-carboxamides (compounds of formula (I)) as inhibitors of human casein kinase I Epsilon, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
-
公开(公告)号：EP1051176B1
公开(公告)日：2006-11-22
申请号：EP99906684.8
申请日：1999-01-27
发明人： EWING, William, R. , BECKER, Michael, R. , CHOI-SLEDESKI, Yong, Mi , PAULS, Heinz, W. , HE, Wei , CONDON, Stephen, M. , DAVIS, Roderick, S. , HANNEY, Barbara, A. , SPADA, Alfred, P. , BURNS, Christopher, J. , JIANG, John, Z. , LI, Aiwen , MYERS, Michael, R. , LAU, Wan, F. , POLI, Gregory, B.
IPC分类号： C07D241/08 , A61K31/495
CPC分类号： C07D471/04 , C07D241/08 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D495/04
摘要： This invention is directed to oxoazaheterocyclyl compounds which inhibit factor Xa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of inhibiting factor Xa.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.024 秒)
