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1.发明公开
公开(公告)号：EP1835895A2
公开(公告)日：2007-09-26
申请号：EP05854081.6
申请日：2005-12-14
发明人： MERRILL, Jean, E. , FUNES, Sandrines , PETKO, Wayne , WIRTZ-BRUGGER, Friederike , CHANDROSS, Karen
IPC分类号： A61K31/05 , A61K31/055 , A61P25/28
CPC分类号： A61K31/05 , A61K31/055 , A61K31/075 , A61K31/138 , A61K31/445
摘要： The invention provides a new use for certain SERM-like phenylnaphthyl compounds that do not exhibit affinity for alpha or beta type estrogen receptors (ER) in the treatment of multiple sclerosis.
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2.发明公开USE OF SELECTED COMPOUNDS FOR PROTECTION OF NEURONES AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS 审中-公开所选化合物的神经元和少突胶质多发性硬化处理保护利用
公开(公告)号：EP1835905A2
公开(公告)日：2007-09-26
申请号：EP05854082.4
申请日：2005-12-14
发明人： MERRILL, Jean, E. , FUNES, Sandrines , PETKO, Wayne , WIRTZ-BRUGGER, Friederike , CHANDROSS, Karen
IPC分类号： A61K31/381 , A61K31/445 , A61K31/47 , A61P25/00
CPC分类号： A61K31/381 , A61K31/445 , A61K31/47
摘要： Certain compounds, including 5,6-dihydro-3,9-dihydroxyindolo[2,1-a-isoquinolin12yl)[4-[2-(1-piperidinyl) ethoxy]phenyl]- methanone and arzoxifen, are useful for providing protection to oligodendrocytes and neurons of multiple sclerosis patients.
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公开(公告)号：EP1697409A1
公开(公告)日：2006-09-06
申请号：EP04811392.2
申请日：2004-11-18
发明人： MERRILL, Jean , YAO, Zhengbin , PETKO, Wayne , KHORKOVA, Olga , KEESLER, George , WANG, Min
CPC分类号： G01N33/5011 , A61K31/727 , A61K38/1709 , C12Q1/26 , G01N33/5017 , G01N33/5047
摘要： A novel neuroprotectant was identified by microarray analysis that is differentially expressed between the ventricular zone and the cortex of human adult and fetal brain. The secreted protein antagonizes Wnt action in Xenopus embryos. Methods are described for modulating free radical neurotoxicity by contacting cells with the protein, treating neuronal diseases associated with free radical-mediated cell death by administering the protein, determining neuroprotective genomic targets associated with select free radical toxicity pathways by screening with the protein and using the protein to identify other compounds that modulate the biological activity of the secreted protein and the cell machinery that reacts to the secreted protein.
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4.发明公开USE OF CERTAIN PHENYL NAPTHYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) 审中-公开作者CERTAIN苯基萘基化合物用于多发性硬化的治疗神经元和少突胶质细胞的保护中的用途（MS）
公开(公告)号：EP1835896A2
公开(公告)日：2007-09-26
申请号：EP05854253.1
申请日：2005-12-14
IPC分类号： A61K31/05 , A61K31/055 , A61P25/28
CPC分类号： A61K31/05 , A61K31/055
摘要： Certain biphenyl compounds, including 5-chloro-6-(4-hydroxyphenyl)-2-naphthalenol and 6-(4-hydroxy-phenyl)-2-Naphthalenemethanol are useful for providing protection to oligodendroctyes and neurons of multiple sclerosis patients.
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5.发明公开USE OF CERTAIN BIPHENYL COMPOUNDS FOR PROTECTION OF NEURONS AND OLIGODENDROCYTES IN THE TREATMENT OF MULTIPLE SCLEROSIS (MS) 审中-公开某些联苯用于在多硬化症治疗的神经元和少突胶质细胞保护中的用途（MS）
公开(公告)号：EP1833472A2
公开(公告)日：2007-09-19
申请号：EP05854263.0
申请日：2005-12-14
CPC分类号： A61K31/136 , A61K31/047 , A61K31/05 , A61K31/135 , A61K31/341 , A61K31/40 , A61K31/402
摘要： A method of treating multiple sclerosis patients by protecting their neurons or oligodendrocytes which comprises administering to a patient having multiple sclerosis a therapeutiaclly effective amount of certain biphenyl compounds as further defined in the specification.
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