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1.发明公开SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) 有权取代的吡啶酮的聚（ADP-核糖）聚合酶的抑制剂（PARP）
公开(公告)号：EP1732896A1
公开(公告)日：2006-12-20
申请号：EP05733556.4
申请日：2005-03-29
发明人： WEINTRAUB, Philip, M. , EASTWOOD, Paul, R. , MEHDI, Shujaath , STEFANY, David, W. , MUSICK, Kwon, Yon , MOORCROFT, Neil , LIM, Sungtaek , JIANG, John, Z. , RUTTEN, Hartmut , PEUKERT, Stefan , SCHWAHN, Uwe
IPC分类号： C07D213/62 , C07D217/24 , C07D401/04 , C07D413/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , A61K31/44 , A61P9/00 , A61P9/10 , A61P19/02 , A61P25/28 , A61P29/00
CPC分类号： C07D213/64 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14
摘要： The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
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2.发明授权SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) 有权取代的吡啶酮的聚（ADP-核糖）聚合酶的抑制剂（PARP）
公开(公告)号：EP1732896B1
公开(公告)日：2012-12-12
申请号：EP05733556.4
申请日：2005-03-29
发明人： WEINTRAUB, Philip, M. , EASTWOOD, Paul, R. , MEHDI, Shujaath , STEFANY, David, W. , MUSICK, Kwon, Yon , MOORCROFT, Neil , LIM, Sungtaek , JIANG, John, Z. , RUTTEN, Hartmut , PEUKERT, Stefan , SCHWAHN, Uwe
IPC分类号： C07D213/62 , C07D217/24 , C07D401/04 , C07D413/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , A61K31/44 , A61P9/00 , A61P9/10 , A61P19/02 , A61P25/28 , A61P29/00
CPC分类号： C07D213/64 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14
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