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1.发明公开Processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-Fluorophenyl)ethyl]-4-piperidinemethanol 审中-公开（A） - （2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇
公开(公告)号：EP1736469A2
公开(公告)日：2006-12-27
申请号：EP06016487.8
申请日：1999-03-11
发明人： Bina, Alan, G. , Daugs, Edward, D. , Evans, Jonathan, C. , Flemming, Hans-Wolfram , Guillamot, Gerard , Hawtorne, Robert, A. , Hilpert, Thomas, H.E. , Hitt, James, E. , King, Chi-Hsin, R. , Koek, Johannes, N. , Laskovics, Frederick, M. , Lefler, John, M. , Margolin, Alexey, L. , Minish, Sharon, K. , Ortyl, Thomas, T. , Rajewski, Lian, G. , Sack, Marvin, J. , Skultety, Paul, F. , Stoltz-Dunn, Sandra, K. , Tigner, Alonzo, L. , Tomlinson, Ian, A.
IPC分类号： C07D211/22 , C07D211/32
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:
摘要翻译： 本发明提供制备（R） - （2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的各种方法。 这些过程可以通过以下方案来表征：
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">2.发明公开Processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol" 审中-公开（A） - （2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇
公开(公告)号：EP1734037A2
公开(公告)日：2006-12-20
申请号：EP06016486.0
申请日：1999-03-11
发明人： Bina, Alan G. , Daugs, Edward D. , Evans, Jonathan C. , Flemming, Hans-Wolfram , Guilamot, Gerard , Hawtorne, Robert A. , Hilpert, Thomas H.E. , Hitt, James E. , King, Chi-Hsin R. , Koek, Johannes N. , Laskovics, Frederick M. , Lefler, John M. , Margolin, Alexey L. , Minish, Sharon K. , Ortyl, Thomas T. , Rajewski, Lian G. , Sack, Marvin J. , Skultety, Paul F. , Stoltz-Dunn, Sandra K. , Tigner, Alonzo L. , Tomlinson, Ian A.
IPC分类号： C07D211/32
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:
摘要翻译： 本发明提供制备（R） - （2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇的各种方法。 这些过程可以通过以下方案来表征：
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">3.发明公开Processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol" 审中-公开（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶 - 甲为（R）-G（A）的制备方法
公开(公告)号：EP1734037A3
公开(公告)日：2010-06-16
申请号：EP06016486.0
申请日：1999-03-11
发明人： Bina, Alan G. , Daugs, Edward D. , Evans, Jonathan C. , Flemming, Hans-Wolfram , Guilamot, Gerard , Hawtorne, Robert A. , Hilpert, Thomas H.E. , Hitt, James E. , King, Chi-Hsin R. , Koek, Johannes N. , Laskovics, Frederick M. , Lefler, John M. , Margolin, Alexey L. , Minish, Sharon K. , Ortyl, Thomas T. , Rajewski, Lian G. , Sack, Marvin J. , Skultety, Paul F. , Stoltz-Dunn, Sandra K. , Tigner, Alonzo L. , Tomlinson, Ian A.
IPC分类号： C07D211/32
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:
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4.发明公开Processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-Fluorophenyl)ethyl]-4-piperidinemethanol 审中-公开（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶 - 甲为（R）-G（A）的制备方法
公开(公告)号：EP1736469A3
公开(公告)日：2010-06-09
申请号：EP06016487.8
申请日：1999-03-11
发明人： Bina, Alan, G. , Daugs, Edward, D. , Evans, Jonathan, C. , Flemming, Hans-Wolfram , Guillamot, Gerard , Hawtorne, Robert, A. , Hilpert, Thomas, H.E. , Hitt, James, E. , King, Chi-Hsin, R. , Koek, Johannes, N. , Laskovics, Frederick, M. , Lefler, John, M. , Margolin, Alexey, L. , Minish, Sharon, K. , Ortyl, Thomas, T. , Rajewski, Lian, G. , Sack, Marvin, J. , Skultety, Paul, F. , Stoltz-Dunn, Sandra, K. , Tigner, Alonzo, L. , Tomlinson, Ian, A.
IPC分类号： C07D211/22 , C07D211/32
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:
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