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1.发明授权THE USE OF R(+)-G(A)-(2,3-DIMETHOXYPHENYL)-1- 2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL FOR THE TREATMENT OF OBSTRUCTIVE SLEEP APNEA 有权R的使用（+） - G（A） - （2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇用于治疗阻塞性睡眠呼吸暂停
公开(公告)号：EP1105132B1
公开(公告)日：2003-09-17
申请号：EP99936000.1
申请日：1999-07-29
IPC分类号： A61K31/445 , A61P11/00 , A61P21/00
CPC分类号： A61K31/445
摘要： A method of treating a patient for a Sleep Disorder comprising administering an effective amount of R-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol or a pharmaceutically acceptable salt thereof to a patient in need of such treatment.
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公开(公告)号：EP1183541B1
公开(公告)日：2006-03-29
申请号：EP00939629.2
申请日：2000-06-07
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/502 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI delta and epsilon phosphorylation of a human Period protein. The present invention is also directed to a method for determining the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.
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公开(公告)号：EP1183541A1
公开(公告)日：2002-03-06
申请号：EP00939629.2
申请日：2000-06-07
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/502 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI δ and ε phosphorylation of a human Period protein. The present invention is also directed to a method for determining the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.
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4.发明授权USE OF (+)-ALPHA-(2,3-DIMETHOXYPHENYL)-1- 2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL IN TREATING DEPRESSIVE DISORDERS AND BIPOLAR DISORDERS 失效的使用（+） - α-（2,3-二甲氧基苯基）-1-（2-（4-氟苯基）乙基-4-哌啶甲醇的抑郁症和双相性精神障碍的治疗
公开(公告)号：EP0888114B1
公开(公告)日：2002-06-26
申请号：EP97907698.1
申请日：1997-02-21
发明人： MONDADORI, Cesare
IPC分类号： A61K31/445 , A61P25/24
CPC分类号： A61K31/445
摘要： The present invention is directed to the use of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol in treating Depressive Disorders and Bipolar Disorders.
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5.发明公开THE USE OF R(+)-G(A)-(2,3-DIMETHOXYPHENYL)-1- 2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL FOR THE TREATMENT OF SLEEP DISORDERS 有权R的使用（+） - G（A） - （2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶治疗睡眠障碍
公开(公告)号：EP1105132A1
公开(公告)日：2001-06-13
申请号：EP99936000.1
申请日：1999-07-29
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： A method of treating a patient for a Sleep Disorder comprising administering an effective amount of R-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol or a pharmaceutically acceptable salt thereof to a patient in need of such treatment.
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