-
1.发明公开SUBSTITUTED 1H-PYRROLO 3,2-B, 3,2-C, AND 2,3-C¨PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON 有权取代的1H-吡咯并[3,2-B，3,2-C和2,3- C]吡啶-2-羧酰胺和相关类似物如酪蛋白激酶I-EPSILON的抑制剂
公开(公告)号：EP1747220A1
公开(公告)日：2007-01-31
申请号：EP04812567.8
申请日：2004-12-01
发明人： METZ, William, A. , HALLEY, Frank , DUTRUC-ROSSET, Gilles , CHOI-SLEDESKI, Yong, Mi , POLI, Gregory, B. , FINK, David, M. , DOERFLINGER, Gilles , HUANG, Bao-Guo , GELORMINI, Ann, Marie , GAMBOA, Juan, A. , GIOVANNI, Andrew , ROEHR, Joachim, E. , TSAY, Joseph, T. , CAMACHO, Fernando , HURST, William, J. , HARNISH, Stephen, W. , CHIANG, Yulin
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention discloses and claims substituted 1H-pyrrolo[3,2-b]pyridine-2-carboxamides, 1H-pyrrolo[3,2-c]pyridine-2-carboxamides and 1H-pyrrolo[2,3-c]pyridine-2-carboxamides (compounds of formula (I)) as inhibitors of human casein kinase I Epsilon, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
-
2.发明授权SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON 有权取代的1H-吡咯并[3,2-B，3,2-C和2,3- C]吡啶-2-羧酰胺和相关类似物如酪蛋白激酶I-EPSILON的抑制剂
公开(公告)号：EP1747220B1
公开(公告)日：2009-04-15
申请号：EP04812567.8
申请日：2004-12-01
发明人： METZ, William, A. , HALLEY, Frank , DUTRUC-ROSSET, Gilles , CHOI-SLEDESKI, Yong, Mi , POLI, Gregory, B. , FINK, David, M. , DOERFLINGER, Gilles , HUANG, Bao-Guo , GELORMINI, Ann, Marie , GAMBOA, Juan, A. , GIOVANNI, Andrew , ROEHR, Joachim, E. , TSAY, Joseph, T. , CAMACHO, Fernando , HURST, William, J. , HARNISH, Stephen, W. , CHIANG, Yulin
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention discloses and claims substituted 1H-pyrrolo[3,2-b]pyridine-2-carboxamides, 1H-pyrrolo[3,2-c]pyridine-2-carboxamides and 1H-pyrrolo[2,3-c]pyridine-2-carboxamides (compounds of formula (I)) as inhibitors of human casein kinase I Epsilon, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
-
公开(公告)号：EP1183541B1
公开(公告)日：2006-03-29
申请号：EP00939629.2
申请日：2000-06-07
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/502 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI delta and epsilon phosphorylation of a human Period protein. The present invention is also directed to a method for determining the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.
-
4.发明公开
公开(公告)号：EP1517695A2
公开(公告)日：2005-03-30
申请号：EP03742164.1
申请日：2003-06-24
发明人： MERRILL, Jean , PU, Su-Fen , KHORKOVA, Olga , JI, Zhongqi , CAMACHO, Fernando , BUSCH, Steve , WANG, Min , CHEN, Ting , DINERSTEIN, Robert, J. , YAO, Zhengbin , CHEN, Yangde , ZHANG, Xin , CHANDROSS, Karen , LEE, Lan
IPC分类号： A61K38/00 , A61K39/395 , C12Q1/00 , C12Q1/70 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5058 , C07K16/24 , C12N5/0622 , C12N2501/585 , G01N33/5029 , G01N33/5073 , G01N2333/51 , G01N2800/285
摘要： Osteopontin is a marker for oligodendrocyte precursor cells. Osteopontin also modulates oligodendrocyte differentiation and central nervous system myelination. Osteopontin induces migration of oligodendrocyte precursors.
-
公开(公告)号：EP1183541A1
公开(公告)日：2002-03-06
申请号：EP00939629.2
申请日：2000-06-07
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/502 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI δ and ε phosphorylation of a human Period protein. The present invention is also directed to a method for determining the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.
-
-
-
-
搜索结果
5 条记录 (耗时 0.01 秒)
