公开(公告)号：EP1585525B1

公开(公告)日：2010-11-17

申请号：EP03814050.5

申请日：2003-12-16

申请人： Aventis Pharmaceuticals Inc.

发明人： ZHU, Bin ,  WETTSTEIN, Joseph ,  PETTY, Margaret

IPC分类号： A61K31/55 ,  A61P25/28

CPC分类号： A61K31/538 ,  A61K31/542 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554

摘要： The invention relates to the use of compound of Formula (I) in treating patients for inflammatory or neuropathic pain as well as various symptoms of multiple schlerosis.

公开(公告)号：EP1368031A2

公开(公告)日：2003-12-10

申请号：EP02714974.9

申请日：2002-02-14

申请人： Aventis Pharmaceuticals, Inc.

发明人： SMITH, Craig, P. ,  RATHBONE, Michel, P. ,  PETTY, Margaret ,  RAMPE, David

IPC分类号： A61K31/4439

CPC分类号： A61K31/4439 ,  Y10S514/903

摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

公开(公告)号：EP1585525A1

公开(公告)日：2005-10-19

申请号：EP03814050.5

申请日：2003-12-16

申请人： AVENTIS PHARMACEUTICALS INC.

发明人： ZHU, Bin ,  WETTSTEIN, Joseph ,  PETTY, Margaret

IPC分类号： A61K31/55 ,  A61P25/28

CPC分类号： A61K31/538 ,  A61K31/542 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554

摘要： The invention relates to the use of compound of Formula (I) in treating patients for inflammatory or neuropathic pain as well as various symptoms of multiple schlerosis.