公开(公告)号：EP2307564A2

公开(公告)日：2011-04-13

申请号：EP09762047.0

申请日：2009-06-10

申请人： Avesthagen Limited

发明人： PATELL, Villoo Morawala ,  ULLANAT, Rajesh ,  SIDEGONDE, Thippeswamy ,  SHEKAR, Sunil ,  MAITY, Sunit ,  GOPALAKRISHNAN, Chellappa ,  GUZDER, Sami Noshir

IPC分类号： C12Q1/68 ,  C12N15/09 ,  C40B50/00

CPC分类号： C12N15/1089 ,  G06F19/18 ,  G06F19/20

摘要： The present invention relates to use of a novel bioinformatics approach for predicting and identifying Scaffold/Matrix attachment regions (S/MARs) from a genomic database. The disclosed methods comprise the steps of generating a library of a subset of genes based on higher and constitutive gene expression predicted from datasets derived from a human autonomic gene expression library, and assessing the 5' UTR intergenic sequences of said subsets to identify the S/MAR sequence.

摘要翻译： 本发明涉及用于预测和鉴定来自基因组数据库的支架/基质附着区（S / MAR）的新型生物信息学方法的用途。 所公开的方法包括以下步骤：基于从源自人类自主基因表达文库的数据集预测的更高和组成型基因表达产生基因子集的文库，评估所述子集的5'UTR基因间序列以鉴定S / MAR序列。

公开(公告)号：EP2362911A1

公开(公告)日：2011-09-07

申请号：EP09823138.4

申请日：2009-10-23

申请人： Avesthagen Limited

发明人： PATELL, Villoo Morawala ,  SHEKAR, Sunil ,  IRENI, Srinivas ,  DYAGA, Gopal

IPC分类号： C12N15/67 ,  C07K16/28 ,  C12N15/13

CPC分类号： C07K16/00 ,  C07K16/2887 ,  C07K2317/24 ,  C12N15/85 ,  C12N2830/46

摘要： The present invention relates to vectors for expression of recombinant anti-CD20 monoclonal antibody. The expression vectors comprise a Scaffold/Matrix Attachment Region such as SEQ ID NO: 1.