公开(公告)号：EP2271396A2

公开(公告)日：2011-01-12

申请号：EP09728936.7

申请日：2009-03-31

Applicant: Avidal Vascular Gmbh

Inventor： HEILMANN, Torsten ,  RICHTER, Christian ,  POST, Sabine

IPC: A61M31/00 ,  A61L31/14 ,  A61L29/14

CPC classification number: A61L29/14 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L29/146 ,  A61L29/16 ,  A61L31/14 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/00 ,  A61M25/0045 ,  A61M25/10 ,  A61M25/1036 ,  A61M25/104 ,  A61M2025/0056 ,  A61M2025/0057 ,  A61M2025/1031 ,  A61M2025/105 ,  A61N1/375 ,  B05D3/12

Abstract: The present invention relates to an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material and which comprises at least one biologically active substance and, optionally at least one matrix compound. The invention also provides a method of producing said expansible hollow part, a medical device covered at least partially with said hollow part, a kit-of-parts comprising said hollow part of the invention and the use of said hollow part as a therapeutic device and for protecting a medical device.

公开(公告)号：EP2632450A1

公开(公告)日：2013-09-04

申请号：EP11764465.8

申请日：2011-08-31

Applicant: Avidal Vascular GmbH

Inventor： HEILMANN, Torsten ,  NOACK, Heiko ,  RICHTER, Christian ,  POST, Sabine

IPC: A61K31/145 ,  A61K31/164 ,  A61K31/337 ,  A61K47/10 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61P35/00 ,  A61P9/00

CPC classification number: A61K31/337 ,  A61K31/145 ,  A61K31/164 ,  A61K45/06 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

Abstract: The present invention relates a pharmaceutical composition comprising a taxane and an inhibitory compound capable of inhibiting the enzyme acetaldehyde dehydrogenase e.g. disulfiram. The pharmaceutical compositions of the invention can be used to coat medical devices such as implants. Such implant can be an expansible hollow part, having at least one opening, which consists of an elastic biocompatible material that comprises elongated micro - cavities in its surface. Medical devices coated with a pharmaceutical composition of the invention exhibit an enhanced transfer of taxane from the surface of said medical device into the target tissue.