公开(公告)号：EP4433110A1

公开(公告)日：2024-09-25

申请号：EP22814344.2

申请日：2022-11-08

申请人： Universität Rostock

发明人： BACKHAUS, Franziska ,  EICKNER, Thomas ,  GRABOW, Niels ,  HIMMLER, Marcus ,  ILLNER, Sabine ,  SCHÜMANN, Kerstin ,  TROSAN, Peter ,  FUCHSLUGER, Thomas Armin

IPC分类号： A61L31/12 ,  A61L31/14 ,  A61F2/14

CPC分类号： A61L2430/1620130101 ,  A61L31/125 ,  A61L31/146 ,  A61F2/1451

公开(公告)号：EP4371583A1

公开(公告)日：2024-05-22

申请号：EP23206089.7

申请日：2023-10-26

申请人： BIOTECH DENTAL

发明人： KELLER, Pierre

IPC分类号： A61L27/06 ,  A61L27/36 ,  A61L27/50 ,  B33Y80/00 ,  A61L31/02 ,  A61L31/14

CPC分类号： B33Y80/00 ,  A61L2430/0220130101 ,  A61L31/022 ,  A61L31/146 ,  A61L2430/1220130101

摘要： La présente invention concerne un dispositif (1) destiné à la régénération osseuse qui comprend une plaque de recouvrement en titane de grade 1 ou de grade 2 réalisée sur mesure qui recouvre un défaut osseux dont la forme permet de recréer la surface de l'os préalablement à l'apparition du défaut osseux et, éventuellement, au moins un moyen de fixation.

公开(公告)号：EP3694571B1

公开(公告)日：2024-05-15

申请号：EP18796221.2

申请日：2018-10-10

IPC分类号： A61L31/06 ,  A61L31/14

CPC分类号： A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L2400/1620130101 ,  A61L2430/3620130101

公开(公告)号：EP2734248B1

公开(公告)日：2018-10-17

申请号：EP12746171.3

申请日：2012-07-20

申请人： Tyrx, Inc.

发明人： LERNER, Daniel, Jeremy ,  MCJAMES, William ,  MANSFIELD, Randy ,  WHITE, Robert, S.

IPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61L31/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L2300/406 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2420/06 ,  C08L77/12

摘要： In some embodiments, a device (102) may include a mesh having at least one bioresorbable polymer coating. The coating may comprise at least one active agent which is eluted over time. The device (102) may at least partially cover at least a portion of an implanted transdermal medical device (100).

公开(公告)号：EP3362110A1

公开(公告)日：2018-08-22

申请号：EP16784251.7

申请日：2016-10-13

申请人： Selentus Science Limited

发明人： NICHOLS, John Benjamin

IPC分类号： A61L31/14 ,  A61L31/16 ,  A61L15/42 ,  A61L15/64

CPC分类号： A61L31/146 ,  A61F13/00021 ,  A61F2013/00463 ,  A61L15/32 ,  A61L15/425 ,  A61L15/64 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/418 ,  A61L2400/04

摘要： A bioresorbable haemostatic foam sponge for adhering to a wound. The sponge has a tissue-contacting surface divided into a plurality of closely-spaced tissue contacting elements. Also disclosed are methods for forming the haemostatic sponge and methods of using the sponge.

公开(公告)号：EP2958933B1

公开(公告)日：2018-08-22

申请号：EP14743041.7

申请日：2014-01-28

申请人： Agency for Science, Technology and Research

发明人： HAUSER, Charlotte ,  SEOW, Wei Yang

IPC分类号： C07K7/06 ,  C07K5/103 ,  A61K38/07 ,  A61K38/06 ,  A61K8/64 ,  A61P19/00 ,  A61L27/52

CPC分类号： A61K8/042 ,  A61K8/64 ,  A61K38/00 ,  A61K2800/5428 ,  A61K2800/91 ,  A61K2800/95 ,  A61L15/425 ,  A61L15/60 ,  A61L27/227 ,  A61L27/52 ,  A61L27/56 ,  A61L31/047 ,  A61L31/145 ,  A61L31/146 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/426 ,  A61L2300/438 ,  A61L2400/06 ,  A61L2400/12 ,  A61Q19/00 ,  A61Q19/08 ,  C07K5/06043 ,  C07K5/0808 ,  C07K5/101 ,  C07K7/06 ,  C07K7/08 ,  C12M25/14 ,  C08L89/00

摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.

公开(公告)号：EP3160387B1

公开(公告)日：2018-08-15

申请号：EP15747600.3

申请日：2015-06-17

申请人： Cordis Corporation

发明人： CHOUBEY, Animesh ,  MARREY, Ramesh

IPC分类号： A61F2/91 ,  A61F2/95 ,  A61F2/962 ,  A61F2/01 ,  A61L31/02 ,  A61L31/14

CPC分类号： A61L31/146 ,  A61F2/01 ,  A61F2/91 ,  A61F2/95 ,  A61F2/962 ,  A61F2002/018 ,  A61F2002/9528 ,  A61F2210/0076 ,  A61F2250/0014 ,  A61F2250/0039 ,  A61F2250/0059 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/022 ,  A61L31/048 ,  A61L2400/16 ,  C08L23/06

摘要： Various embodiments for a composite endovascular device (and variations thereof) that include an inner polymer structure and an outer thin-film shape memory structure. The inner polymer structure extends from a distal end to a proximal end along a longitudinal axis. The outer thin-film shape-memory structure has an inner thin-film surface coupled to the outer surface of the inner polymer structure from the distal end to the proximal end with a retrieval member at the proximal end to allow for the prosthesis to be retrieved after placement in a body vessel. The inner polymeric structure can be blended with a suitable bio-active agent or the agent can be loaded into the pores. The device can be permanent or temporary by virtue of being retrievable.

公开(公告)号：EP2804895B1

公开(公告)日：2018-08-01

申请号：EP12795199.4

申请日：2012-11-14

申请人： W. L. Gore & Associates, Inc.

发明人： KOVACH, Larry, J. ,  RADSPINNER, Rachel

IPC分类号： C08J7/04 ,  B29C55/00 ,  C08J5/18 ,  D04H1/4391 ,  B01D67/00

CPC分类号： C08J7/047 ,  A61L31/048 ,  A61L31/10 ,  A61L31/146 ,  B29C55/005 ,  B29K2027/18 ,  C08J2327/18 ,  C08J2427/18 ,  D04H1/4318 ,  D04H1/4391 ,  C08L27/12 ,  C08L27/18

摘要： Articles including expanded fluoropolymer membranes having serpentine fibrils are provided. The fluoropolymer membranes exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. The membrane may include a fluoropolymer and/or elastomer. Additionally, the article has an elongation in at least one direction of at least about 100% and a matrix tensile strength of at least about 50 MPa. The article may be formed by (1) expanding a dried, extruded fluoropolymer tape in at least one direction to produce an expanded fluoropolymer membrane and (2) retracting the expanded fluoropolymer membrane in at least one direction of expansion by applying heat or by adding a solvent. The application of a tensile force at least partially straightens the serpentine fibrils, thereby elongating the article. The expanded fiuoropolymer membrane may include a microstructure of substantially only fibrils. The membranes may be imbibed with an elastomeric materia! to form a composite.

公开(公告)号：EP3110451A4

公开(公告)日：2018-06-20

申请号：EP15755938

申请日：2015-02-26

申请人： UNIV OF MASSACHUSETTS MEDICAL SCHOOL

发明人： SONG JIE ,  ZHANG JING

IPC分类号： A61L31/06 ,  A61F2/00 ,  A61K47/34 ,  C08G63/08

CPC分类号： A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/06 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/414 ,  C08G63/664 ,  C08G63/823 ,  C08G2230/00 ,  C08L67/04

摘要： The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as S1P.

公开(公告)号：EP3331583A1

公开(公告)日：2018-06-13

申请号：EP16754436.0

申请日：2016-08-03

申请人： Universitätsklinikum Jena ,  KKF UG

发明人： RAUCHFUSS, Falk ,  SETTMACHER, Utz ,  KLEMM, Dieter ,  FRIED, Wolfgang ,  RICHTER, Thomas ,  PETZOLD-WELCKE, Katrin ,  RUHE, Carola

IPC分类号： A61L31/00 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61F2/04 ,  A61F2002/041 ,  A61L31/005 ,  A61L31/10 ,  A61L31/146 ,  A61L2400/12 ,  A61L2420/08 ,  C08L1/02 ,  C08L1/00

摘要： Medical Implant (100), comprising - a microbial cellulose tube (1), comprising a wall (2) having an inner surface (3) and an outer surface (4), wherein the wall comprises several layers (5, 6, 7) of microbial cellulose, wherein said layers are concentric or substantially concentric to a longitudinal axis (L) of the tube, - a stent (9) which placed inside of the microbial cellulose tube (1), wherein an outer surface (10) of the stent contacts the inner surface (3) of the microbial cellulose tube (1), and method for producing such implant. The implant can be covered with newly created bile duct epithelium, thereby creating a new bile duct from body cells. The implant can be removed after completion of creation of the new bile duct. So, the implant as suitable as a temporary implant. The implant can be used for surgery, such as surgery of gall bladder, bile duct and/or liver, e.g. gall bladder removal, hepatobiliary malignancy surgery or liver transplantation. The implant can particularly be used for repairing or regeneration of bile duct. Further fields of use are the use as esophagus implant or urether implant.