公开(公告)号：EP1255541A2

公开(公告)日：2002-11-13

申请号：EP01911580.7

申请日：2001-02-02

申请人： Axxima Pharmaceuticals Aktiengesellschaft

发明人： BEVEC, Dorian ,  HAUBER, Joachim ,  OBERT, Sabine ,  KERI, Gyorgy ,  ORFI, Laszlo ,  SZEKELY, Istvan ,  CHOIDAS, Axel ,  BACHER, Gerald

IPC分类号： A61K31/155 ,  A61P31/18 ,  A61K31/22 ,  A61P31/04

CPC分类号： A61K45/06 ,  A61K31/155 ,  A61K31/17 ,  A61K31/4164 ,  C07C281/18 ,  Y02A50/402 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/479 ,  Y02A50/481

摘要： The present invention relates to aromatic guanylhydrazone compounds and their use as pharmaceutically active agents, especially for prophylaxis and treatment of virally caused diseases and infections, including opportunistic infections. The inventive guanylhydrazone compounds are also useful as inhibitors of deoxyhypusine synthase and as inhibitors for nuclear export in infectious diseases and may be used to regulate bacterially induced TNF-alpha production. Furthermore, the aromatic guanylhydrazones exhibit antibacterial activity against Gram positive and Gram negative bacteria and can be regarded as a novel class of antibiotics. In addition, methods for prophylaxis and treatment of virally or bacterially induced infections and diseases are disclosed together with pharmaceutical compositions useful within said methods containing at least one aromatic guanylhydrazone of the present invention as active ingredient.