公开(公告)号：EP1517908A2

公开(公告)日：2005-03-30

申请号：EP03761822.0

申请日：2003-06-26

申请人： BANYU PHARMACEUTICAL CO., LTD.

发明人： OTAKE, Norikazu,c/o BANYU PHARMACEUTICAL CO., LTD ,  MORIYA, Minoru,c/o BANYU PHARMACEUTICAL CO., LTD. ,  OGINO, Yoshio,c/o BANYU PHARMACEUTICAL CO., LTD. ,  MATSUDA, Kenji,c/o BANYU PHARMACEUTICAL CO., LTD ,  NAGAE, Yoshikazu,c/o BANYU PHARMACEUTICAL CO.,LTD ,  KANATANI, Akio,c/o BANYU PHARMACEUTICAL CO., LTD ,  FUKAMI, Takehiro,c/o BANYU PHARMACEUTICAL CO.,LTD

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D403/08 ,  C07D473/00 ,  C07D405/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/52 ,  A61P25/00 ,  A61P9/00 ,  A61P3/00

CPC分类号： C07D473/30 ,  C07D405/04 ,  C07D471/04 ,  C07D471/10 ,  C07D473/00 ,  C07D491/04

摘要： A compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally! I substituted methine; E is nitrogen, methine or hydroxyl, substituted methine; n is 0 or 1; T, U, V and W are independently!, nitrogen or optionally substituted methine; X is -N(SOZR4)-, N (COR5) - or -CO- ; Y is -C (R6) (R7) - , -O- or -N (RS) - provided that the compound (I) when E is nitrogen, n is 0, X is -CO-, and Y is -0 is excluded). is useful as an agent for the treatment of various diseases related to NPY neuropeptide Y.