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1.发明公开METHOD FOR DETECTING p53 DYSFUNCTION, METHOD FOR MOLECULAR DIAGNOSIS OF CANCER AND METHOD FOR EVALUATING COMPOUND EFFECTIVE IN TREATING CANCER 审中-公开方法评估在癌症的有效连接的癌症治疗的分子诊断和方法的检出p53的运行失常，方法
公开(公告)号：EP1847603A1
公开(公告)日：2007-10-24
申请号：EP06712843.9
申请日：2006-02-01
发明人： KOTANI, Hidehito, c/o Banyu Pharmaceutical Co. Ltd , YAMANAKA, Kazunori, c/o Banyu Pharma. Co. Ltd. , MIZUARAI, Shinji, c/o Banyu Pharmaceutical Co. Ltd
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178 , G01N33/574 , G01N2333/4748 , G01N2800/52
摘要： Detection of p53 dysfunction or molecular diagnosis of cancer is carried out by a method comprising the steps of measuring the expression level of at least one gene selected from the group consisting of CARS, MOCOS, TNFRSF9, LOC56901 and GEF-H1 or a gene which is functionally equivalent to the gene in a test tissue or a test cell; comparing the expression level of the gene with that of a corresponding gene in a normal tissue or a normal cell; and determining whether or not the expression level of the gene in the test tissue or the test cell is significantly higher than that of the corresponding gene in the normal tissue or the normal cell based on the comparison result. According to the method for molecular diagnosis of the present invention, regardless of the presence of p53 mutation or without directly detecting p53 mutation, it becomes possible to detect p53 dysfunction or to diagnose cancer caused by p53 dysfunction.
摘要翻译： p53的功能障碍或癌症的分子诊断检测是通过包括测量选自汽车，MOCOS，TNFRSF9，LOC56901和GEF-H1或基因的所有它是所选择的至少一种基因的表达水平的步骤的方法进行 功能上等效于在测试的组织或测试细胞的基因; 比较的确在正常组织或正常细胞中的相应基因的基因的表达水平; 和确定性采矿是否在测试组织或测试细胞中的基因的表达水平比在正常组织或基于该比较结果，正常细胞中的相应基因的显着更高。 。根据本发明的分子诊断的方法中，不管p53突变的或不直接检测p53基因突变的存在，有可能检测到p53的功能障碍或诊断癌症被p53功能障碍引起的。
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