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1.发明授权A METHOD FOR SCREENING COMPOUNEDS USING THE GUANOSINE TRIPHOSPHATE (GTP) BINDING PROTEIN-COUPLED RECEPTOR PROTEIN, BG37 无效法搜索对于其中GUANOSINTRIPHOSPHAT-（GTP）结合蛋白偶联型受体蛋白BG37中使用的部件
公开(公告)号：EP1347052B1
公开(公告)日：2010-05-05
申请号：EP01976875.3
申请日：2001-10-30
发明人： MARUYAMA, T., c/o BANYU PHARMACEUTICAL CO., LTD. , NAKAMURA, Takao, c/o BANYU PHARMACEUTICAL CO., LTD , ITADANI, Hiraku, c/o BANYU PHARMACEUTICAL CO., LTD , TANAKA, K., c/o BANYU PHARMACEUTICAL CO., LTD.
CPC分类号： C07K14/705
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2.发明公开GUANOSINE TRIPHOSPHATE (GTP) BINDING PROTEIN-COUPLED RECEPTOR PROTEIN, BG37 无效法搜索对于其中GUANOSINTRIPHOSPHAT-（GTP）结合蛋白偶联型受体蛋白BG37中使用的部件
公开(公告)号：EP1347052A1
公开(公告)日：2003-09-24
申请号：EP01976875.3
申请日：2001-10-30
发明人： MARUYAMA, T., c/o BANYU PHARMACEUTICAL CO., LTD. , NAKAMURA, Takao, c/o BANYU PHARMACEUTICAL CO., LTD , ITADANI, Hiraku, c/o BANYU PHARMACEUTICAL CO., LTD , TANAKA, K., c/o BANYU PHARMACEUTICAL CO., LTD.
CPC分类号： C07K14/705
摘要： The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene "BG37". cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR "BG37" genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the "BG37" receptor.
摘要翻译： 本发明人进行相似性搜索GenBank中已知的G蛋白偶联受体蛋白质的氨基酸序列，并获得了一种新的人GPCR基因“BG37”。 的cDNA含有克隆的基因的ORF和其核苷酸序列，其确定性开采。 更过来，从小鼠和大鼠新颖GPCR“BG37”基因中分离得到。 本发明的新的GPCR的使用使得配体的筛选，所述化合物抑制结合的配体，和药物可以从“BG37”受体调节信号转导的候选化合物。
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