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    Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process
    1.
    发明公开
    Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process 失效
    一种制备2-氨基甲酰-1,4-二氢吡啶衍生物和中间体的对它们的制备方法。

    公开(公告)号：EP0101023A1

    公开(公告)日：1984-02-22

    申请号：EP83107707.8

    申请日：1983-08-04

    申请人： BANYU PHARMACEUTICAL CO., LTD.

    发明人： Miyano, Tetsuji ,  Suzuki, Kunio ,  Ushijima, Ryosuke ,  Nakagawa, Susumu

    IPC分类号： C07D211/90 ,  A61K31/455

    CPC分类号： C07D295/205 ,  C07D211/90

    摘要： A process for preparing a 2-carbamoyloxyalkyl-1,4-dihydropyridine derivative represented by the general formula:
    which comprises:

    (a) reacting a 3-amino-3-carbamoyloxyalkylacrylic acid derivative represented by the general formula:
    with a benzylidene compound represented by the general formula:

    (b) reacting the 3-amino-3-carbamoyloxyalkylacrylic acid derivative of the general formula II with an aldehyde comoound reoresented bv the aeneral formula:
    and a β-keto-ester compound represented by the general formula:

    (c) reacting a 3-carbamoyloxyalkylpropiolic acid derivative represented by the general formula:
    with the benzylidene compound of the general formula III and ammonia or its salt: or
    (d) reacting the 3-carbamoyloxyalkylpropiolic acid derivative of the general formula VI with the aldehyde compound of the general formula IV, the β-keto-ester compound of the general formula V and ammonia or its salt, and the intermediates of formula II and VI.

    1,4-Dihydropyridine derivatives and processes for preparing the same
    3.
    发明公开
    1,4-Dihydropyridine derivatives and processes for preparing the same 失效
    1,4-二氢吡啶衍生物和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0063359A1

    公开(公告)日：1982-10-27

    申请号：EP82103145.7

    申请日：1982-04-14

    申请人： BANYU PHARMACEUTICAL CO., LTD.

    发明人： Miyano, Tetsuji ,  Suzuki, Kunio ,  Harada, Nobuo ,  Asai, Akira

    IPC分类号： C07D211/90 ,  A61K31/445

    CPC分类号： C07D211/90

    摘要： Novel 1,4-dihydropyridine derivatives or the pharmacologically acceptable salts thereof represented by the following general formula (I), and process for preparing the same.
    where R' is dialkoxyalkyl, formyl, formylalkyl, or hydroxyalkyl; R 2 represents alkoxyalkyl, alkenyloxyalkyl, aryloxyalkyl, or aralkyloxyalkyl; R 3 denotes alkyl, haloalkyl, alkoxyalkyl, alkenyloxyalkyl, aryloxyalkyl, aralkyloxyalkyl, or N,N-di-substituted aminoalkyl (the substituents are the same or different alkyl, aralkyl, or aryl); R 4 is alkyl, dialkoxyalkyl, formyl, formylalkyl, or hydroxyalkyl: and R 5 is ortho-, meta-, or paranitro. The compounds of the present invention possess vaso-dilation activities and hypotensive activities, and are expected to be highly useful medicines for the blood circulatory system.

    摘要翻译： 由以下通式（I）表示的新颖的1,4-二氢吡啶衍生物或其药学上可接受的盐及其制备方法。 其中R 1是二烷氧基烷基，甲酰基，甲酰基烷基或羟烷基; R 2表示烷氧基烷基，烯氧基烷基，芳氧基烷基或芳烷氧基烷基; R 3表示烷基，卤代烷基，烷氧基烷烃，烯氧基烷基，芳氧基烷基，芳烷氧基烷基或N，N-二取代的氨基烷基（取代基是相同或不同的烷基，芳烷基或芳基）。 R 4是烷基，二烷氧基烷基，甲酰基，甲酰基烷基或羟烷基; R 5为邻 - ，间 - 或对硝基苯基。 本发明化合物具有血管扩张活性和降血压作用，预计血液循环系统是非常有用的药物。

    2-Substituted or unsubstituted aminocarbonyloxyalkyl-1,4-dihydropyridines
    6.
    发明公开
    2-Substituted or unsubstituted aminocarbonyloxyalkyl-1,4-dihydropyridines 失效
    2-取代的或未取代的氨基羰基氧基-1,4-二氢吡啶。

    公开(公告)号：EP0063747A1

    公开(公告)日：1982-11-03

    申请号：EP82103144.0

    申请日：1982-04-14

    申请人： BANYU PHARMACEUTICAL CO., LTD.

    发明人： Miyano, Tetsuji ,  Suzuki, Kunio ,  Harada, Nobuo

    IPC分类号： C07D211/90 ,  C07D401/12 ,  C07D413/12 ,  A61K31/445

    CPC分类号： C07D211/90

    摘要： Novel compounds having vasodilation and hypotensive effects are represented by the formula
    where R' is halogen, nitro, cyano or lower alkoxy; each of R 2 and R 3 is lower alkyl, lower haloalkyl, lower alkoxyalkyl, aralkyloxyalkyl, aryloxyalkyl, lower alkenoxyalkyl, N,N-di-lower alkylaminoalkyl, N-lower alkyl-N-aralkylaminoalkyl, piperidylalkyl, 4-lower alkyl piperazinylalkyl, norpholinoalkyl or 1-pyrrolidinylalkyl; R' is lower alkyl; A is lower alkylene; and R 5 is hydrogen, lower alkyl, cycloalkyl of 3 to 7 carbon atoms, or aryl unsubstituted or substituted by one or two substituents selected from halogen, nitro, lower alkyl, lower alkoxy, di-lower alkylamino and cyano.
    Also disclosed are processes for their preparation.