公开(公告)号：EP1226237A2

公开(公告)日：2002-07-31

申请号：EP00959449.0

申请日：2000-08-25

申请人： BASF AKTIENGESELLSCHAFT ,  GPC Biotech Inc.

发明人： TAYLOR, Neil, R. ,  BORHANI, David ,  EPSTEIN, David ,  RUDOLPH, Johannes ,  RITTER, Kurt ,  FUJIMORI, Taro ,  ROBINSON, Simon ,  ECKSTEIN, Jens ,  HAUPT, Andreas ,  WALKER, Nigel ,  DIXON, Richard, W. ,  CHOQUETTE, Deborah ,  BLANCHARD, Jill ,  KLUGE, Arthur ,  PAL, Kollol ,  BOCKOVICH, Nicholas ,  COME, Jon ,  HEDIGER, Mark

IPC分类号： C12N9/16 ,  C12N15/55 ,  C30B29/58 ,  G06F17/50 ,  C07K7/06

CPC分类号： C07K5/1016 ,  A61K38/00 ,  C07K5/1027 ,  C12N9/16

摘要： The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.

公开(公告)号：EP1611136A2

公开(公告)日：2006-01-04

申请号：EP04759113.6

申请日：2004-04-06

申请人： GPC Biotech Inc.

发明人： BOCKOVICH, Nicholas ,  KLUGE, Arthur ,  OALMANN, Chris ,  MURTHI, Krishna, K. ,  RAM, Siya ,  WANG, Zhongguo ,  HUANG, Jianxing

IPC分类号： C07D487/04 ,  C07D231/54 ,  C07D403/12 ,  C07D413/12 ,  C07D519/00 ,  C07F9/6561 ,  A61K31/416 ,  A61K31/519 ,  A61K31/675 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07F9/65583 ,  C07F9/6561

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) of formulae (II) and (I) wherein the substituents are as defined in the claims and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

公开(公告)号：EP1709051A1

公开(公告)日：2006-10-11

申请号：EP04815554.3

申请日：2004-12-21

申请人： GPC Biotech Inc.

发明人： BOCKOVICH, Nicholas ,  KLUGE, Arthur, F. ,  OALMANN, Chris ,  MURTHI, Krishna, K. ,  RAM, Siya ,  WANG, Zhongguo ,  HUANG, Jianxing

IPC分类号： C07D487/04 ,  C07D231/54 ,  C07D403/12 ,  C07D413/12 ,  C07D519/00 ,  C07F9/6561 ,  A61K31/416 ,  A61K31/519 ,  A61K31/675 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07F9/6561

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) of formula (I) wherein the substituents are as defined in the claims and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.

公开(公告)号：EP1446405A2

公开(公告)日：2004-08-18

申请号：EP02797047.4

申请日：2002-10-15

申请人： GPC Biotech Inc. ,  Becker, Frank

发明人： BOCKOVICH, Nicholas ,  KLUGE, Arthur F. ,  RAM, Siya ,  WANG, Zhonghuo ,  OALMANN, Chris ,  MURTHI, Krishna K.

IPC分类号： C07D487/04 ,  C07D231/54 ,  C07F9/6561 ,  C07F9/6503 ,  C07D403/12 ,  A61K31/519 ,  A61K31/416 ,  A61K31/675 ,  A61P35/00 ,  A61P31/12

CPC分类号： C07F9/6561 ,  C07D231/54 ,  C07D403/12 ,  C07D487/04 ,  C07F9/65583 ,  C40B30/04 ,  G01N2500/10

摘要： The invention pertains to novel cyclin dependent kinase inhibitors (cdks) and specifically, but not exclusively, as inhibitors of cdk/cyclin complexes. As described herein, the inhibitors of this invention are capable of inhibiting the cell-cycle machinery and consequently may be useful in modulating cell-cycle progression, ultimately controlling cell growth and differentiation. Such compounds would be useful for treating subjects having disorders associated with excessive cell proliferation.