公开(公告)号：EP3040453B1

公开(公告)日：2024-01-03

申请号：EP14839877.9

申请日：2014-08-27

发明人： YAMANISHI, Yoko ,  ARAI, Fumihito ,  KURIKI, Hiroki

IPC分类号： C30B29/58 ,  C07K1/30 ,  C07K14/80 ,  C12N9/00 ,  C12N9/24 ,  C30B7/12 ,  C30B30/02 ,  C12N9/36 ,  C12N9/06 ,  B25J7/00

公开(公告)号：EP2912214B1

公开(公告)日：2023-06-07

申请号：EP13783062.6

申请日：2013-10-25

发明人： IKONOMIDIS, Kyriakos ,  POULAS, Konstantinos ,  TZIMAS, Ioannis ,  WETLING, John F.

IPC分类号： C30B7/00 ,  C30B29/58 ,  C12N9/36 ,  C30B29/54 ,  C30B30/02

公开(公告)号：EP2121186B1

公开(公告)日：2019-10-30

申请号：EP08775628.4

申请日：2008-03-05

申请人： Rhodia Opérations ,  Centre National de la Recherche Scientifique (C.N.R.S.)

发明人： JOANICOT, Mathieu ,  LAVAL, Philippe ,  LENG, Jacques ,  SALMON, Jean-Baptiste

IPC分类号： B01L3/00 ,  C30B7/00 ,  C30B7/08 ,  G01N35/08 ,  C30B29/58

公开(公告)号：EP3360883A1

公开(公告)日：2018-08-15

申请号：EP16853468.3

申请日：2016-09-28

申请人： Toray Industries, Inc.

发明人： NAKABAYASHI, Iori ,  TSUCHIKURA, Hiroshi ,  KUWABARA, Atsushi ,  ADACHI, Hiroaki

IPC分类号： C07K1/14 ,  C30B29/58 ,  C12N15/09

CPC分类号： C07K1/14 ,  C12N15/09 ,  C30B29/58

摘要： Provided are a fiber-containing crystal, a method for preparing the fiber-containing crystal, an apparatus for preparing the fiber-containing crystal, and a chemical soaking apparatus, the fiber-containing crystal comprising: a crystal body which is a crystal of a biological substance; and a plurality of fibers at least partially incorporated in the crystal body.

公开(公告)号：EP3250585A1

公开(公告)日：2017-12-06

申请号：EP16711899.1

申请日：2016-01-26

申请人： Yeda Research and Development Co., Ltd.

发明人： YONATH, Ada ,  EYAL, Zohar ,  MATZOV, Donna ,  ROZENBERG, Haim ,  ZIMMERMAN, Ella ,  BASHAN, Anat

IPC分类号： C07K14/31 ,  C30B29/58 ,  G06F19/16

CPC分类号： C07K14/31 ,  C07D211/54 ,  C07D263/20 ,  C07H17/08 ,  C07K2299/00 ,  G16B15/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/50 ,  G16C20/60

摘要： A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

公开(公告)号：EP2900815B1

公开(公告)日：2017-06-21

申请号：EP13779509.2

申请日：2013-09-30

申请人： Aarhus Universitet ,  Region Midtjylland

发明人： ANDERSEN, Jacob Lauwring ,  GESSER, Borbala ,  NISSEN, Poul ,  IVERSEN, Lars

IPC分类号： C12N9/12 ,  C12N15/62 ,  C30B29/58 ,  G06F19/16

CPC分类号： C12N9/12 ,  C07K2319/21 ,  C12Y207/11001 ,  C30B7/00 ,  C30B29/58 ,  C40B30/02 ,  G06F19/12 ,  G06F19/16 ,  G06F19/706

公开(公告)号：EP2991768A4

公开(公告)日：2016-12-28

申请号：EP14791893

申请日：2014-04-28

申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIV

发明人： WEIERSTALL UWE ,  SPENCE JOHN ,  DOAK R BRUCE

IPC分类号： B01L99/00 ,  B05B1/14 ,  B05B7/08 ,  C30B7/00 ,  C30B7/02 ,  C30B29/58

CPC分类号： B05B1/10 ,  B05B1/02 ,  B05B7/064 ,  B05B7/066 ,  B05B7/08 ,  B05B7/24 ,  C30B7/00 ,  C30B7/02 ,  C30B29/58

摘要： An injector apparatus and methods for use, where the injector apparatus comprises: (a) hydraulic stage having first and second ends and including a housing defining a cavity, a primary plunger disposed in the cavity and a secondary plunger, (b) a pressurization system coupled to the hydraulic stage's first end, where the primary plunger is in fluid communication with the pressurization system and is in mechanical communication with the secondary plunger, (c) a reservoir bore defined in the hydraulic stage housing and configured to receive the primary plunger's second end, where the secondary plunger is disposed within the reservoir bore and (d) a nozzle assembly including a housing, a gas tube and a nozzle capillary, where the nozzle capillary is partially disposed in and is substantially coaxial with the gas tube, where the nozzle capillary's first end is in fluid communication with the reservoir bore's second end.

摘要翻译： 一种注射器装置和使用方法，其中所述注射器装置包括：（a）具有第一和第二端并包括限定空腔的壳体的液压平台，设置在所述空腔中的主柱塞和次级柱塞，（b）加压系统 耦合到液压级的第一端，其中主柱塞与加压系统流体连通并且与次级柱塞机械连通，（c）限定在液压级壳体中的储存器孔，并且构造成容纳主柱塞的第二端 （d）喷嘴组件，其包括壳体，气体管和喷嘴毛细管，其中喷嘴毛细管部分地设置在气体管中并基本上与气体管同轴，其中， 喷嘴毛细管的第一端与储存器孔的第二端流体连通。

公开(公告)号：EP2370618B1

公开(公告)日：2015-02-18

申请号：EP09831345.5

申请日：2009-12-08

申请人： FPInnovations

发明人： BECK, Stephanie ,  BOUCHARD, Jean ,  BERRY, Richard ,  GODBOUT, Joseph Donat Louis

IPC分类号： C30B29/58 ,  B29C41/02 ,  C08J5/18 ,  C08L1/02 ,  C30B7/04 ,  C08B15/08

CPC分类号： C08B15/08

公开(公告)号：EP2526120A4

公开(公告)日：2013-11-27

申请号：EP11734282

申请日：2011-01-18

申请人： FPINNOVATIONS

发明人： BECK STEPHANIE ,  BOUCHARD JEAN ,  BERRY RICHARD

IPC分类号： C08B1/00 ,  B01F17/00 ,  B82Y30/00 ,  C08B15/08 ,  C08J3/20 ,  C08J5/18 ,  C08J5/22 ,  C08L1/02 ,  C09D101/02 ,  C30B29/58

CPC分类号： C08B15/08 ,  C08J3/12 ,  C08J5/18 ,  C08J2301/02 ,  Y10T428/2982 ,  Y10T428/2991

摘要： Dried nanocrystalline cellulose (NCC), in particular films of NCC, of controlled water dispersibility and a method to control the dispersibility of dried NCC by controlling electrolyte solution ionic strength and ion valency is described. Neutral M-NCC suspensions containing monovalent counterions (e.g., M=Na+, K+, NH4+, Et4N+) produced by neutralization of acid-form NCC (H-NCC) with the appropriate hydroxide, are readily dispersible in water when fully dried; this is in contrast to H-NCC. The dispersion of dried M-NCC in aqueous media is effectively prevented by a combination of (1) increased electrolyte concentration and ionic strength, and (2) higher valency of the cation component of the dissolved salt. Additionally, pre-treatment of dried M-NCC films with an electrolyte solution having a polyvalent cation, for example a divalent or trivalent cation is sufficient to prevent the subsequent dispersion of the M-NCC film in pure water.

公开(公告)号：EP2455397A1

公开(公告)日：2012-05-23

申请号：EP10799831.2

申请日：2010-07-13

申请人： National University Corporation Kobe University ,  Japan Synchrotron Radiation Research Institute

发明人： KATAOKA, Tohru ,  SHIMA, Fumi ,  TAMURA, Atsuo ,  KUMASAKA, Takashi

IPC分类号： C07K14/82 ,  C12N15/09 ,  C30B7/04 ,  C30B29/58 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K14/82 ,  C07K2299/00 ,  C30B7/00 ,  C30B29/58 ,  G01N33/566 ,  G01N2333/4719 ,  G01N2500/02

摘要： An object of the present invention is to provide a co-crystal of a Ras polypeptide which adopts a conformation having a pocket on the molecular surface of Ras and GTP or a GTP analog, a production method for the crystal, and a screening method for a Ras function inhibitor based on information about the conformation obtained by X-ray crystallographic analysis using the crystal. The object is achieved by focusing on a mutation which adopts a conformation having a pocket on the molecular surface of Ras, acquiring a mutant Ras polypeptide having introduced therein such mutation, producing a co-crystal of the mutant Ras polypeptide and a GTP analog, and further subjecting the co-crystal to X-ray crystallographic analysis to acquire structural information about the conformation including information about the structure surrounding the pocket.

摘要翻译： 本发明的目的是提供一种Ras多肽的共晶，其采用在Ras和GTP的分子表面上具有口袋的构象或GTP类似物，晶体的制备方法和用于 基于通过使用晶体的X射线晶体学分析获得的关于构象的信息的Ras功能抑制剂。 该目的通过聚焦在Ras分子表面上具有口袋构象的突变来实现，获得在其中引入了这种突变的突变型Ras多肽，产生突变型Ras多肽和GTP类似物的共晶体，以及 进一步对共晶进行X射线晶体学分析以获得关于构象的结构信息，包括关于口袋周围结构的信息。