公开(公告)号：EP3001835B1

公开(公告)日：2017-04-05

申请号：EP14722653.4

申请日：2014-05-07

申请人： BASF SE

发明人： DEMMING, Stefanie ,  THOTLA, Suman ,  WITTENBERG, Jens ,  IFFLAND, Gabriele ,  BRÜGGEMANN, Till, Christian ,  HOELZL, Yvonne ,  SIEGEL, Wolfgang ,  FREYER, Stephan

IPC分类号： C07C67/08 ,  C07C67/54 ,  B01D3/14

CPC分类号： C07C67/08 ,  B01D3/141 ,  C07C67/54 ,  C07C69/40

摘要： The invention relates to a process for continuously preparing di-C1-3-alkyl succinates by reacting succinic acid with an C1-3-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100° C., wherein a mixture, comprising succinic acid, C1-3-alkanol, mono-C1-3-alkyl succinate, di-C1-3-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C1-3-alkanol to succinic acid added to the mixing zone, and not including the C1-3-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C1-3-alkanol to give di-C1-3-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C1-3-alkanol and water are removed in a top draw of the column, di-C1-3-alkyl succinate is removed in a side draw of the column, and wherein mono-C1-3-alkyl succinate and succinic acid are removed in a bottom draw of the column.

公开(公告)号：EP2978852A1

公开(公告)日：2016-02-03

申请号：EP14774843.8

申请日：2014-03-03

申请人： BASF SE

发明人： ERNST, Burkhard ,  EHRESMANN, Manfred ,  KORADIN, Christopher ,  PLETSCH, Andreas ,  BONNEKESSEL, Melanie ,  KAEDING, Thomas ,  SCHEIN-ALBRECHT, Karin ,  DEMMING, Stefanie ,  WEBER, Franz ,  SIEGEL, Wolfgang ,  SCHRöDER, Hartwig ,  FREYER, Stephan ,  ÖDMAN, Peter

IPC分类号： C12P17/18

CPC分类号： C07D493/04 ,  A01N43/40 ,  C12P17/181

摘要： The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula (III) and/or Formula (IV) and/or Formula (V) from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula (III) and/or Formula (IV) and/or Formula (V), including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula (IV) and/or Formula (V) in order to produce pest control compositions, in particular insecticides, comprising such compounds.

公开(公告)号：EP2978852B1

公开(公告)日：2018-10-17

申请号：EP14774843.8

申请日：2014-03-03

申请人： BASF SE

发明人： ERNST, Burkhard ,  EHRESMANN, Manfred ,  KORADIN, Christopher ,  PLETSCH, Andreas ,  BONNEKESSEL, Melanie ,  KAEDING, Thomas ,  SCHEIN-ALBRECHT, Karin ,  DEMMING, Stefanie ,  WEBER, Franz ,  SIEGEL, Wolfgang ,  SCHRöDER, Hartwig ,  FREYER, Stephan ,  ÖDMAN, Peter

IPC分类号： C12P17/18 ,  A01N43/40

CPC分类号： C07D493/04 ,  A01N43/40 ,  C12P17/181

摘要： The invention pertains to processes to produce dry biomass of pyripyropene producer organisms, processes to obtain pyripyropenes from such dry biomass, as well as to processes to produce compounds of Formula III and/or Formula IV and/or Formula V from the pyripyropenes obtained from the dry biomass. The invention does further pertain to the dry biomass itself, as well as processes using said dry biomass to obtain pyripyropenes for the production of compounds of Formula III and/or Formula IV and/or Formula V, including processes using said dry biomass to obtain pyripyropenes or compounds of Formula III and/or Formula IV and/or Formula V in order to produce pest control compositions, in particular insecticides, comprising such compounds.

公开(公告)号：EP3001835A1

公开(公告)日：2016-04-06

申请号：EP14722653.4

申请日：2014-05-07

申请人： BASF SE

发明人： DEMMING, Stefanie ,  THOTLA, Suman ,  WITTENBERG, Jens ,  IFFLAND, Gabriele ,  BRÜGGEMANN, Till, Christian ,  HOELZL, Yvonne ,  SIEGEL, Wolfgang ,  FREYER, Stephan

IPC分类号： C07C67/08

CPC分类号： C07C67/08 ,  B01D3/141 ,  C07C67/54 ,  C07C69/40

摘要： The invention relates to a process for continuously preparing di-C1-3-alkyl succinates by reacting succinic acid with an C1-3-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100° C., wherein a mixture, comprising succinic acid, C1-3-alkanol, mono-C1-3-alkyl succinate, di-C1-3-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C1-3-alkanol to succinic acid added to the mixing zone, and not including the C1-3-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C1-3-alkanol to give di-C1-3-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C1-3-alkanol and water are removed in a top draw of the column, di-C1-3-alkyl succinate is removed in a side draw of the column, and wherein mono-C1-3-alkyl succinate and succinic acid are removed in a bottom draw of the column.

摘要翻译： 本发明涉及一种在固定床非均相酸性酯化催化剂存在下，在管式反应器中在一定范围内的温度下使琥珀酸与C 1-3烷醇反应连续制备二-C 1-3烷基琥珀酸盐的方法 为60〜100℃，其中在混合阶段形成包含琥珀酸，C 1-3 - 链烷醇，琥珀酸单-C1-烷基酯，琥珀酸二-C1-烷基酯和水的混合物， 进料到管状反应器的入口，其中管式反应器的出口流量的5％至75％作为循环物流直接循环到混合阶段，并且加入了C 3-链烷醇与琥珀酸的摩尔比 到混合区，并且不包括在再循环流中的C 1-3链烷醇和琥珀酸，其范围为2.0-9.5。 本发明还涉及一种将琥珀酸酯化为C 3-链烷醇的反应器流出物分离以通过蒸馏得到二-C1-烷基琥珀酸盐的方法，其中分离是在分隔壁塔中进行的，其中在 在柱的顶部抽出物中除去C 3-链烷醇和水，在柱的侧馏分中除去琥珀酸二-C1--烷基酯，并且其中除去琥珀酸单C 1-3 - 烷基酯和琥珀酸 在列的底部绘制。