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    MEANS AND METHODS FOR PRODUCING AMIDE COMPOUNDS WITH LESS ACRYLIC ACID
    1.
    发明公开
    MEANS AND METHODS FOR PRODUCING AMIDE COMPOUNDS WITH LESS ACRYLIC ACID 审中-公开
    用较少丙烯酸生产酰胺化合物的方法和方法

    公开(公告)号：EP3201349A2

    公开(公告)日：2017-08-09

    申请号：EP15794829.0

    申请日：2015-09-30

    Applicant: BASF SE

    Inventor： BUDDE, Michael ,  BRAUN, Michael ,  DAEUWEL, Juergen ,  OEDMAN, Peter ,  BALDENIUS, Kai-Uwe ,  KLEINER, Matthias ,  FREYER, Stephan

    IPC: C12P13/02

    CPC classification number: C12P13/02 ,  C12N9/78 ,  C12N9/80 ,  C12Y305/01004 ,  C12Y305/05001

    Abstract: The present invention relates to means and methods for producing an amide compound from a nitrile compound with less acrylic acid as by-product using a Nitrile hydratase (NHase) and Amidase producing microorganism as biocatalyst. Also provided is an aqueous amide compound obtained by the methods of the invention as well as a composition comprising acrylamide or polyacrylamide as well as a dried microorganism exhibiting a NHase/Amidase activity ratio of at least 400 when being brought into contact with a nitrile compound to convert said nitrile compound into an amide compound.

    Abstract translation: 本发明涉及使用腈水合酶（NHase）和产酰胺酶微生物作为生物催化剂由腈化合物和少量丙烯酸副产物生产酰胺化合物的方法和方法。 还提供了通过本发明的方法获得的含水酰胺化合物以及包含丙烯酰胺或聚丙烯酰胺的组合物以及当与腈化合物接触时显示至少400的NHase /酰胺酶活性比的干燥微生物与 将所述腈化合物转化成酰胺化合物。

    FERMENTATIVE HERSTELLUNG ORGANISCHER VERBINDUNGEN UNTER EINSATZ DEXTRIN-HALTIGER MEDIEN
    6.
    发明授权
    FERMENTATIVE HERSTELLUNG ORGANISCHER VERBINDUNGEN UNTER EINSATZ DEXTRIN-HALTIGER MEDIEN 有权
    发酵产生有机化合物使用糊精含MEDIA

    公开(公告)号：EP1957658B1

    公开(公告)日：2011-07-20

    申请号：EP06819766.4

    申请日：2006-11-27

    Applicant: BASF SE

    Inventor： BOY, Matthias ,  FREYER, Stephan

    IPC: C12P19/14 ,  C12P13/08 ,  C12P13/14

    CPC classification number: C12P7/26 ,  C12P7/42 ,  C12P7/62 ,  C12P7/6418 ,  C12P7/6427 ,  C12P7/6463 ,  C12P13/00 ,  C12P13/005 ,  C12P13/04 ,  C12P19/14 ,  C12P19/30 ,  C12P19/38

    Abstract: The invention relates to a method for producing at least one organic compound comprising at least 3 C-atoms or at least 2 C-atoms and at least 1 N-atom by fermentation. Said method comprises the following steps: a1) a starch source is ground in order to obtain a grinding material which contains at least one part of the non-starch containing solid components of the starch source; a2) the grinding material is suspended in an aqueous liquid and said grinding material contained in the aqueous liquid is liquefied in the presence of at least one enzyme which liquefies starch, an aqueous substance which contains dextrin (1), which contains at least one part of the non-starch containing solid components of the starch source, is obtained; and b) the aqueous substance which contains dextrin (1) is used in fermentation for cultivating a micro-organism which is capable of over-producing the organic compounds; enzymes, which hydrolyse the dextrin into monosaccharides, are not added or are added in an amount of less than 0.001 wt. %, in relation to the total weight of the used starch source.

    METHOD OF CULTIVATING MICROORGANISMS HAVING NITRILE HYDRATASE ACTIVITY
    8.
    发明公开
    METHOD OF CULTIVATING MICROORGANISMS HAVING NITRILE HYDRATASE ACTIVITY 审中-公开
    培养具有腈水解酶活性的微生物的方法

    公开(公告)号：EP3201316A1

    公开(公告)日：2017-08-09

    申请号：EP15775162.9

    申请日：2015-09-30

    Applicant: BASF SE

    Inventor： HAGE, Kerstin ,  SCHWALB, Carsten ,  SPRÖTE, Petra ,  ÖDMAN, Peter ,  BALDENIUS, Kai-Uwe ,  ERNST, Burkhard ,  STEIGELMANN, Gunter ,  FREYER, Stephan ,  BOLLSCHWEILER, Claus ,  BRAUN, Michael Günter ,  DAEUWEL, Juergen

    IPC: C12N1/20 ,  C12N9/88

    Abstract: The present invention relates to methods for cultivating a nitrile hydratase producing microorganism, compositions for cultivating a nitrile hydratase producing microorganism, and use of compositions comprising a saccharide and an organic acid for cultivating a nitrile hydratase producing microorganism. The composition provided in and to be employed in context with the present invention is particularly suitable for inducing both, growth and nitrile hydratase production of corresponding microorganisms.

    Abstract translation: 腈水合酶生产微生物的培养方法，培养腈水合酶生产微生物的组合物以及含有糖和有机酸的组合物的用途技术领域本发明涉及培养腈水合酶生产微生物的方法，用于培养腈水合酶生产微生物的组合物以及包含糖和有机酸的组合物的用途。 提供于本发明中并在本发明中使用的组合物特别适用于诱导相应微生物的生长和腈水合酶产生。

    PROCESS FOR CONTINUOUSLY PREPARING DI-C1-3-ALKYL SUCCINATES
    9.
    发明公开
    PROCESS FOR CONTINUOUSLY PREPARING DI-C1-3-ALKYL SUCCINATES 有权
    VERFAHREN ZUR KONTINUIERLICHEN HERSTELLUNG VON DI-C1-3-ALKYLSUCCINATEN

    公开(公告)号：EP3001835A1

    公开(公告)日：2016-04-06

    申请号：EP14722653.4

    申请日：2014-05-07

    Applicant: BASF SE

    Inventor： DEMMING, Stefanie ,  THOTLA, Suman ,  WITTENBERG, Jens ,  IFFLAND, Gabriele ,  BRÜGGEMANN, Till, Christian ,  HOELZL, Yvonne ,  SIEGEL, Wolfgang ,  FREYER, Stephan

    IPC: C07C67/08

    CPC classification number: C07C67/08 ,  B01D3/141 ,  C07C67/54 ,  C07C69/40

    Abstract: The invention relates to a process for continuously preparing di-C1-3-alkyl succinates by reacting succinic acid with an C1-3-alkanol in the presence of a fixed-bed heterogeneous acidic esterification catalyst in a tubular reactor at a temperature in the range of from 60 to 100° C., wherein a mixture, comprising succinic acid, C1-3-alkanol, mono-C1-3-alkyl succinate, di-C1-3-alkyl succinate and water, is formed in a mixing stage and fed to the entrance of the tubular reactor, and wherein 5 to 75% of the outlet flow rate of the tubular reactor are recycled directly to the mixing stage as a recycle stream, and the molar ratio of C1-3-alkanol to succinic acid added to the mixing zone, and not including the C1-3-alkanol and succinic acid at the recycle stream, being in the range of from 2.0 to 9.5. The invention furthermore relates to a process for separating the reactor effluent of an esterification of succinic acid with an C1-3-alkanol to give di-C1-3-alkyl succinates by distillation, wherein the separation is performed in a divided wall column in which C1-3-alkanol and water are removed in a top draw of the column, di-C1-3-alkyl succinate is removed in a side draw of the column, and wherein mono-C1-3-alkyl succinate and succinic acid are removed in a bottom draw of the column.

    Abstract translation: 本发明涉及一种在固定床非均相酸性酯化催化剂存在下，在管式反应器中在一定范围内的温度下使琥珀酸与C 1-3烷醇反应连续制备二-C 1-3烷基琥珀酸盐的方法 为60〜100℃，其中在混合阶段形成包含琥珀酸，C 1-3 - 链烷醇，琥珀酸单-C1-烷基酯，琥珀酸二-C1-烷基酯和水的混合物， 进料到管状反应器的入口，其中管式反应器的出口流量的5％至75％作为循环物流直接循环到混合阶段，并且加入了C 3-链烷醇与琥珀酸的摩尔比 到混合区，并且不包括在再循环流中的C 1-3链烷醇和琥珀酸，其范围为2.0-9.5。 本发明还涉及一种将琥珀酸酯化为C 3-链烷醇的反应器流出物分离以通过蒸馏得到二-C1-烷基琥珀酸盐的方法，其中分离是在分隔壁塔中进行的，其中在 在柱的顶部抽出物中除去C 3-链烷醇和水，在柱的侧馏分中除去琥珀酸二-C1--烷基酯，并且其中除去琥珀酸单C 1-3 - 烷基酯和琥珀酸 在列的底部绘制。

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