公开(公告)号：EP3587396A1

公开(公告)日：2020-01-01

申请号：EP18180091.3

申请日：2018-06-27

申请人： BASF SE

发明人： Yerande, Swapnil ,  Kapse, Prashant ,  Narayanan, Sukunath ,  Goetz, Roland

IPC分类号： C07C303/40 ,  C07C205/58

摘要： The presently claimed invention relates to an improved method of isolating 3-nitrobenzenesulfonamide of formula I

In the 3-nitrobenzenesulfonamide of formula I, R 1 and R 2 each independently of one another substituted or unsubstituted, linear or branched C 1 -C 8 -alkyl; substituted or unsubstituted C 3 -C 8 -cycloalkyl; or R 1 and R 2 together with the atom to which they are bonded form a 5-, 6-, 7- or 8-membered substituted or unsubstituted, saturated or unsaturated heterocyclic ring which contains 1 or 2 further heteroatoms selected from the group consisting of O and S. The isolation of the 3-nitrobenzenesulfonamide of the formula I from a reaction mixture is performed by acidifying the reaction mixture, separating and washing an organic phase from the acidified reaction mixture to obtain a washed organic phase, obtaining a concentrated organic phase by concentrating a washed organic phase, cooling the concentrated organic phase to obtain a suspension and isolating the 3-nitrobenzenesulfonamide of the formula (I) from the suspension.