公开(公告)号：EP3974417A1

公开(公告)日：2022-03-30

申请号：EP20198841.7

申请日：2020-09-29

申请人： BASF SE

发明人： Koradin, Christopher ,  Shinde, Harish ,  McLaughlin, Martin John ,  Kaduskar, Rahul ,  Staehle, Philipp ,  Goetz, Roland ,  Khamkar, Sunil

IPC分类号： C07D277/32

摘要： The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.

公开(公告)号：EP4293014A1

公开(公告)日：2023-12-20

申请号：EP22179089.2

申请日：2022-06-15

申请人： BASF SE

发明人： Rack, Michael ,  Kaduskar, Rahul ,  Gockel, Birgit ,  Knoll, Daniel Maximilian ,  Goetz, Roland ,  Shinde, Harish

IPC分类号： C07D213/61 ,  C07B39/00 ,  C07D213/73

摘要： The present invention relates to a process for the chlorination of halogenated pyridines with molecular chlorine in the presence of water under UV light irradiation in the vapor phase. The present invention further relates to a multi-step process for producing 5-chloro-3,6-difluoro-pyridin-2-amine and to the novel intermediate compounds 2,3-dichloro-5,6-difluoropyridine and 2,5-dichloro-3,6-difluoro-pyridine, which can be obtained by the process of the present invention starting form 5-chloro-2,3-difluoropyridine and 3-chloro-2,5-difluoro-pyridine.

公开(公告)号：EP4032893A1

公开(公告)日：2022-07-27

申请号：EP21153036.5

申请日：2021-01-22

申请人： BASF SE

发明人： KORADIN, Christopher ,  MCLAUGHLIN, Martin John ,  SHINDE, Harish ,  KADUSKAR, Rahul ,  Goetz, Roland ,  GARIVET, Guillaume Michel Jacques

IPC分类号： C07D495/04

摘要： The present invention relates to a method for preparing an enantiomerically enriched form of 3-(2-chlorothiazol-5-yl)-8-methyl-7-oxo-6-phenyl-2,3-dihydrothiazolo[3,2-a]pyrimidin-4-ium-5-olate.

公开(公告)号：EP4311828A1

公开(公告)日：2024-01-31

申请号：EP22186856.5

申请日：2022-07-26

申请人： BASF SE ,  Lianhe Chemical Technology Co., Ltd.

发明人： Rack, Michael ,  Xie, Enrique ,  Dang, Weijie ,  Li, Dave ,  Yi, Kaiqiang ,  Kaduskar, Rahul ,  Gockel, Birgit ,  Shinde, Harish ,  Goetz, Roland ,  Knoll, Daniel Maximilian

IPC分类号： C07D213/61 ,  C07D213/73

摘要： The present invention relates to a process for the chlorination of 3-halopyridine with molecular chlorine in the presence of water under UV light irradiation in the vapor phase. The present invention further relates to a multi-step process for producing 5-chloro-3,6-difluoropyridin-2-amine.

公开(公告)号：EP3587396A1

公开(公告)日：2020-01-01

申请号：EP18180091.3

申请日：2018-06-27

申请人： BASF SE

发明人： Yerande, Swapnil ,  Kapse, Prashant ,  Narayanan, Sukunath ,  Goetz, Roland

IPC分类号： C07C303/40 ,  C07C205/58

摘要： The presently claimed invention relates to an improved method of isolating 3-nitrobenzenesulfonamide of formula I

In the 3-nitrobenzenesulfonamide of formula I, R 1 and R 2 each independently of one another substituted or unsubstituted, linear or branched C 1 -C 8 -alkyl; substituted or unsubstituted C 3 -C 8 -cycloalkyl; or R 1 and R 2 together with the atom to which they are bonded form a 5-, 6-, 7- or 8-membered substituted or unsubstituted, saturated or unsaturated heterocyclic ring which contains 1 or 2 further heteroatoms selected from the group consisting of O and S. The isolation of the 3-nitrobenzenesulfonamide of the formula I from a reaction mixture is performed by acidifying the reaction mixture, separating and washing an organic phase from the acidified reaction mixture to obtain a washed organic phase, obtaining a concentrated organic phase by concentrating a washed organic phase, cooling the concentrated organic phase to obtain a suspension and isolating the 3-nitrobenzenesulfonamide of the formula (I) from the suspension.