公开(公告)号：EP2788344A1

公开(公告)日：2014-10-15

申请号：EP12855925.9

申请日：2012-12-03

Applicant: BASF SE

Inventor： HAFNER, Andreas ,  HINTERMANN, Tobias ,  BLATTER, Fritz ,  RODEL, Eva

IPC: C07D403/10 ,  A61K31/506 ,  A61P31/10

CPC classification number: A61K31/506 ,  A61K31/194 ,  C07D403/10 ,  A61K2300/00

Abstract: A novel solid form of Voriconazole comprises the active ingredient (2R,3S)-2-(2,4- difluorophenyl)- 3-(5-fluoropyrimidin- 4-yl)-1 -(1H-1,2,4-triazol-1 -yl)butan-2-ol and fumaric acid. The solid composition comprising the two components shows improved properties such as water solubility, crystallization behavior and stability.