-
公开(公告)号：EP3024830A2
公开(公告)日：2016-06-01
申请号：EP14741630.9
申请日：2014-07-22
申请人： BASF SE
发明人： HAFNER, Andreas , BLATTER, Fritz , SZELAGIEWICZ, Martin , SIEBENHAAR, Bernd , CHIODO, Tiziana , HINTERMANN, Tobias , SALVADOR, Beate , VOSSEN, Marcus
IPC分类号： C07D417/12 , A61K31/506
CPC分类号： C07D417/12 , C07B2200/13 , C07D275/06
摘要： The present invention primarily relates to molecular crystalline substances, preferably salts of Dasatinib in crystalline form, comprising a compound of formula 1, preferably a cation of a compound of formula 1, and a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin, preferably an anion thereof. The Invention is further related to pharmaceutical compositions comprising such a substance. Furthermore, the Invention relates to processes for preparing said substances. The invention also relates to several aspects of using said substances or pharmaceutical compositions to treat a disease.
摘要翻译： 本发明主要涉及分子结晶物质，优选结晶形式的达沙替尼盐，其包含式1化合物，优选式1化合物的阳离子和选自戊二酸，烟酸的第二化合物 和糖精，优选其阴离子。 本发明进一步涉及包含这种物质的药物组合物。 此外，本发明涉及制备所述物质的方法。 本发明还涉及使用所述物质或药物组合物治疗疾病的若干方面。
-
2.发明公开MULTICOMPONENT CRYSTALLINE SYSTEM COMPRISING DEFERASIROX AND ISONICOTINAMIDE AND A PROCESS FOR THE PREPARATION THEREOF 有权结晶多组分系统和拉罗司ISONIKOTINAMID及其制造方法
公开(公告)号：EP2880019A1
公开(公告)日：2015-06-10
申请号：EP13750525.1
申请日：2013-08-05
申请人： BASF SE
发明人： HAFNER, Andreas , BLATTER, Fritz , RÖDEL, Eva , SZELAGIEWICZ, Martin , CHIODO, Tiziana , HINTERMANN, Tobias , SALVADOR, Beate , VOSSEN, Marcus
IPC分类号： C07D249/08 , A61K31/4196 , A61P7/00
CPC分类号： C07D213/81 , C07B2200/13 , C07D249/08
摘要： The present invention refers to a multicomponent crystalline system (co-crystal) comprising a compound of formula (1) (4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid; INN:Deferasirox) formula (1) and a compound of formula (2) (Isonicotinamide; pyridine-4-carboxamide) formula (2), as well as to a process for obtaining the same.
-
公开(公告)号：EP2788344A1
公开(公告)日：2014-10-15
申请号：EP12855925.9
申请日：2012-12-03
申请人： BASF SE
IPC分类号： C07D403/10 , A61K31/506 , A61P31/10
CPC分类号： A61K31/506 , A61K31/194 , C07D403/10 , A61K2300/00
摘要： A novel solid form of Voriconazole comprises the active ingredient (2R,3S)-2-(2,4- difluorophenyl)- 3-(5-fluoropyrimidin- 4-yl)-1 -(1H-1,2,4-triazol-1 -yl)butan-2-ol and fumaric acid. The solid composition comprising the two components shows improved properties such as water solubility, crystallization behavior and stability.
-
4.发明公开
公开(公告)号：EP2296772A1
公开(公告)日：2011-03-23
申请号：EP09793912.8
申请日：2009-06-23
申请人： BASF SE
发明人： HAFNER, Andreas , BUTHE, Andreas , VAN DER SCHAAF, Paul Adriaan , KAUFMANN, Franz , BRADLEY, Gordon
CPC分类号： B01D9/005 , A61K9/1688 , C07K14/37
摘要： Disclosed is a process for modifying the morphology and/or polymorphism of an organic substance, which process comprises treating the solid substance, or a solution or dispersion thereof, with one or more amphiphilic proteins.
摘要翻译： 公开了一种用于改变有机物质的形态和/或多态性的方法，该方法包括用一种或多种两亲性蛋白质处理固体物质或其溶液或分散体。
-
公开(公告)号：EP3022592A1
公开(公告)日：2016-05-25
申请号：EP14739110.6
申请日：2014-07-08
申请人： BASF SE
发明人： HAFNER, Andreas , VON MÜHLENEN, Adrian , ENGER, Olivier , GALLINET, Benjamin , FERRINI, Rolando , MARJANOVIC, Nenad , STALDER, Martin , BASSET, Guillaume , LUETOLF, Fabian
CPC分类号： G02B5/1809 , B82Y20/00 , B82Y30/00 , E06B2009/2417 , E06B2009/2464 , F21S11/007 , G02B5/203 , G02B5/208
摘要： A translucent construction element comprising a layer of translucent substrate, which contains a surface structured with nanoplanes of inclined angle relative to the substrate plane, and coated with an interrupted metallic layer covering at least a part of said nanoplanes, is characterized by a high density of interruptions in the metallic layer of low thickness; the periodicity of interruptions in the metallic layer generally is from the range 50 to 1000 nm and the thickness of the metallic layer typically is from the range 1 to 50 nm. The construction element may be integrated, for example, into windows, plastic films or sheets or glazings, especially for the purpose of light management.
-
6.发明公开MULTICOMPONENT CRYSTALLINE SYSTEM COMPRISING NILOTINIB AND SELECTED CO-CRYSTAL FORMERS 审中-公开KRISTALLINES系统麻醉剂美沙酮KIMPONENTEN MIT NILOTINIB UNDAUSGEWÄHLTENCO-KRISTALL-FORMERN
公开(公告)号：EP2909191A1
公开(公告)日：2015-08-26
申请号：EP13783008.9
申请日：2013-10-16
申请人： BASF SE
发明人： CHIODO, Tiziana , HAFNER, Andreas , HINTERMANN, Tobias , SALVADOR, Beate , SZELAGIEWICZ, Martin , BLATTER, Fritz , RöDEL, Eva , VOSSEN, Marcus
IPC分类号： C07D401/14 , A61K31/506 , A61P35/02
CPC分类号： C07D401/14
摘要： The present invention relates to crystalline materials comprising nilotinib and a carboxylic acid, carboxylic acid ester, carboxylic acid amide or sulfonic acid as a co-crystal former, and to pharmaceutical compositions comprising said materials. The invention also relates to processes for preparing said crystalline materials and to methods of using said crystalline materials to treat a disease condition in which tyrosine kinase inhibition is beneficial.
摘要翻译： 本发明涉及包含尼罗替尼和羧酸，羧酸酯，羧酸酰胺或磺酸作为共晶体形成剂的结晶材料以及包含所述材料的药物组合物。 本发明还涉及制备所述结晶材料的方法以及使用所述结晶材料治疗其中酪氨酸激酶抑制是有益的疾病状况的方法。
-
7.发明公开MULTICOMPONENT CRYSTALLINE SYSTEM OF ROSUVASTATIN CALCIUM SALT AND VANILLIN 审中-公开结晶多组分体系OFF瑞舒伐他汀钙和香兰素
公开(公告)号：EP2699552A1
公开(公告)日：2014-02-26
申请号：EP12714011.9
申请日：2012-04-16
申请人： BASF SE
IPC分类号： C07D239/42 , A61K31/505 , A61P9/00
CPC分类号： A61K31/505 , A61K31/11 , A61K47/10 , C07D239/42
摘要： A novel solid form of Rosuvastatin comprises as the active ingredient a salt of bis[(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)-amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid] and vanillin or vanillin derivatives. The crystal comprising the two components, and minor amounts of water, shows improved properties such as crystallization behavior stability and decreased hydroscopic behavior.
-
公开(公告)号：EP2909191B1
公开(公告)日：2019-03-20
申请号：EP13783008.9
申请日：2013-10-16
申请人： BASF SE
发明人： CHIODO, Tiziana , HAFNER, Andreas , HINTERMANN, Tobias , SALVADOR, Beate , SZELAGIEWICZ, Martin , BLATTER, Fritz , RöDEL, Eva , VOSSEN, Marcus
IPC分类号： C07D401/14 , A61K31/506 , A61P35/02
-
公开(公告)号：EP3237941A1
公开(公告)日：2017-11-01
申请号：EP15872065.6
申请日：2015-12-18
申请人： BASF SE
发明人： STALDER, Martin , GALLINET, Benjamin , LUETOLF, Fabian , BASSET, Guillaume , FERRINI, Rolando , BUJARD, Patrice , VON MUEHLENEN, Adrian , HAFNER, Andreas
CPC分类号： G02B5/282 , C23C14/0629 , C23C14/20 , C23C14/5873 , E06B9/24 , E06B2009/2417 , G02B1/118 , G02B5/281 , H01L31/02168
摘要： A translucent or transparent film or sheet device shows angular-independent IR reflectance, which comprises a substrate (1) covered with a layer of a dielectric high refractive index material (4) containing a thin metallic layer (3) embedded in said material, and a further layer (5) of translucent or transparent material covering said layer (4) of dielectric high refractive index material, characterized in that the embedded metal layer (3) is periodically interrupted with a periodicity of 50 to 800 nm such that metal covers at least 70% of the substrate area. The device may advantageously be integrated into a window, a glass facade element or especially onto a photovoltaic (PV) device, where it reduces the fraction of IR radiation passing into the building, or reduces heat take-up and thus lowers the operating temperature and improves the efficiency of the PV cell.
摘要翻译： 半透明或透明薄膜或片材包括用包含嵌入材料中的薄金属层（3）的介电高折射率材料（4）的层覆盖的基底（1），以及另一个半透明或透明的层（5） （4）的材料覆盖层，以50至800nm的周期性周期性中断嵌入的金属层（3），使得金属覆盖至少70％的衬底面积。 还提供了包括该膜或片材的窗户，玻璃幕墙元件或太阳能面板，用于制造该膜或片材的方法，以及使用该膜或片材减少太阳红外线辐射传输的方法。
-
10.发明授权METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES 有权方法在无细胞的细胞和文化相关的发明取得了一定的，申请添加剂
公开(公告)号：EP2464739B1
公开(公告)日：2016-01-13
申请号：EP10740674.6
申请日：2010-08-11
申请人： BASF SE
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.015 秒)
