公开(公告)号：EP3177591A1

公开(公告)日：2017-06-14

申请号：EP15748020.3

申请日：2015-08-03

Applicant: BASF SE

Inventor： VIERTELHAUS, Martin ,  CHIODO, Tiziana ,  SALVADOR, Beate ,  VOSSEN, Marcus ,  HAFNER, Andreas ,  HINTERMANN, Tobias ,  WEISHAAR, Walter ,  HELLMANN, Rolf

IPC: C07D213/40

CPC classification number: A61K31/4402 ,  C07D213/40

Abstract: and a second compound selected from the group consisting of co-crystal formers and solvents. The invention is further related to pharmaceutical compositions comprising such multi-component crystals. Furthermore, the invention relates to processes for preparing said multi-component crystals. The invention also relates to several aspects of using said multi-component crystals or pharmaceutical compositions to treat a disease.

Abstract translation: 本发明主要涉及包含式1化合物和选自共晶体形成剂和溶剂的第二种化合物的多组分晶体。 本发明进一步涉及包含这种多组分晶体的药物组合物。 此外，本发明涉及制备所述多组分晶体的方法。 本发明还涉及使用所述多组分晶体或药物组合物治疗疾病的几个方面。

公开(公告)号：EP3867258A1

公开(公告)日：2021-08-25

申请号：EP19786589.2

申请日：2019-10-17

Applicant: BASF SE

Inventor： PUHL, Michael ,  WLOCH, Sebastian ,  OEDMAN, Peter ,  LETZEL, Anne-Catrin ,  SCHROEDER, Hartwig ,  MALISZ, Jacek ,  SEIBERT-LUDWIG, Daniel ,  KAPPERT, Emiel Jan ,  WONG, Chung Huan ,  BARROS GROSS, Michael ,  VIERTELHAUS, Martin

IPC: C07H1/06 ,  C07H1/08

公开(公告)号：EP4448710A1

公开(公告)日：2024-10-23

申请号：EP22834555.9

申请日：2022-12-08

Applicant: BASF SE

Inventor： HINRICHSEN, Bernd ,  VIERTELHAUS, Martin ,  MUELLER, Michael Klemens ,  VOGES, Matthias ,  SCHMIDT, Astrid ,  ARNDT, Matthias

IPC: C11D11/00 ,  C11D3/33 ,  C11D17/06

公开(公告)号：EP3908584A1

公开(公告)日：2021-11-17

申请号：EP20700674.3

申请日：2020-01-10

Applicant: BASF SE

Inventor： GEBHARDT, Joachim ,  VIERTELHAUS, Martin ,  CHIODO, Tiziana ,  RACK, Michael ,  KLAUBER, Eric George ,  XU, Wen ,  GOETZ, Roland ,  VOGT, Florian ,  GOCKEL, Birgit ,  SOERGEL, Sebastian

IPC: C07D403/12

公开(公告)号：EP3160963A1

公开(公告)日：2017-05-03

申请号：EP15731329.7

申请日：2015-06-24

Applicant: BASF SE

Inventor： VIERTELHAUS, Martin ,  CHIODO, Tiziana ,  SALVADOR, Beate ,  VOSSEN, Marcus ,  HAFNER, Andreas ,  HINTERMANN, Tobias ,  SZELAGIEWICZ, Martin ,  BLATTER, Fritz

IPC: C07D417/12 ,  A61K31/506

CPC classification number: C07D417/12

Abstract: The present invention primarily relates to multicomponent crystals comprising a compound of formula 1 and a second compound selected from the group consisting of menthol and vanillin. The invention is further related to pharmaceutical compositions comprising such multicomponent crystals. Furthermore, the invention relates to processes for preparing said multicomponent crystals. The invention also relates to several aspects of using said multicomponent crystals or pharmaceutical compositions to treat a disease.

Abstract translation: 本发明主要涉及包含式1化合物和选自薄荷醇和香草醛的第二化合物的多组分晶体。 本发明还涉及包含这种多组分晶体的药物组合物。 此外，本发明涉及制备所述多组分晶体的方法。 本发明还涉及使用所述多组分晶体或药物组合物治疗疾病的几个方面。

公开(公告)号：EP3080141A1

公开(公告)日：2016-10-19

申请号：EP14809636.5

申请日：2014-12-09

Applicant: BASF SE

Inventor： CHIODO, Tiziana ,  SALVADOR, Beate ,  VOSSEN, Marcus ,  HAFNER, Andreas ,  HINTERMANN, Tobias ,  SZELAGIEWICZ, Martin ,  BLATTER, Fritz ,  VIERTELHAUS, Martin ,  WEISHAAR, Walter

IPC: C07J43/00 ,  A61K9/14 ,  A61K31/58 ,  A61P35/00

CPC classification number: A61K31/58 ,  A61K9/14 ,  C07B2200/13 ,  C07J43/003

Abstract: Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.