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    METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE
    1.
    发明公开
    METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE 审中-公开
    制备2'-O-果糖基丙糖的方法

    公开(公告)号：EP3191498A1

    公开(公告)日：2017-07-19

    申请号：EP15763307.4

    申请日：2015-09-11

    Applicant: BASF SE

    Inventor： PUHL, Michael ,  DITRICH, Klaus ,  KELLER, Andreas ,  DIMITROVA, Pepa ,  WEINGARTEN, Melanie ,  SIEGEL, Wolfgang

    IPC: C07H3/06 ,  C07H15/26

    Abstract: The present invention relates to a method for preparing 2'-O-fucosyllactose, the 2'-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(=O)-R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6- alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4- alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.

    Abstract translation: 本发明涉及制备2'-O-岩藻糖基乳糖的方法，由该方法得到的2'-O-岩藻糖基乳糖及其用途。 该方法包括使以下通式（I）的经过硅烷化的，被保护的岩藻糖衍生物与至少一种三（C1-C6-烷基）甲硅烷基碘化物反应，随后使如此获得的产物与通式（II） 在一个基地的存在。 在式（I）和（II）中，变量各自如下定义：RSi相同或不同，并且是式SiR a R b R c的残基; R 1为C（= O）-R 11残基或SiR 12 R 13 R 14残基，R 2相同或不同且为C 1 -C 8烷基或一起形成未取代或具有1至6个甲基的直链C 3 -C 6烷二基 作为取代基; R3是相同或不同的并且是C1-C8-烷基或一起形成未取代的或具有1-6个甲基作为取代基的直链C1-C4-链烷二基。

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