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1.发明公开ANTAGONISTS OF FACTOR VIII INTERACTION WITH LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 有权相互作用的因子VIII和LRP（“低密度脂蛋白受体相关蛋白”）之间拮抗剂
公开(公告)号：EP1497330A2
公开(公告)日：2005-01-19
申请号：EP03725109.7
申请日：2003-04-28
发明人： MERTENS, Koenraad , BOVENSCHEN, Arend, Niels , VOORBERG, Jan , RIEGER, Manfred , SCHEIFLINGER, Friedrich
IPC分类号： C07K14/755 , C07K16/36 , A61K38/37 , A61K39/395 , A61P7/04
CPC分类号： C07K14/755 , A61K38/00 , A61K39/00 , C07K14/775 , C07K16/36 , C07K2317/622 , C07K2317/76
摘要： The present invention concerns the use of peptides derived from and antibodies generated against Factor VIII and the inhibition of Factor VIII interaction with LRP. Furthermore, the present invention concerns a method to inhibit LRP interaction with Factor VIII as well as a method to decrease Factor VIII degradation and/or prolong Factor VIII half-life in a biological fluid and/or a method to treat patients suffering from a blood coagulation disorder, especially Haemophilia A. The present invention also concerns a pharmaceutical composition useful for the decrease of Factor VIII degradation in a biological fluid, the inhibition of Factor VIII interaction with LRP, and/or the prolongation of Factor Vlll half-life in a biological fluid for treatment of a blood coagulation disorder, especially Haemophilia A.
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2.发明授权ANTAGONISTS OF FACTOR VIII INTERACTION WITH LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 有权相互作用的因子VIII和LRP（“低密度脂蛋白受体相关蛋白”）之间拮抗剂
公开(公告)号：EP1497330B1
公开(公告)日：2010-04-07
申请号：EP03725109.7
申请日：2003-04-28
发明人： MERTENS, Koenraad , BOVENSCHEN, Arend, Niels , VOORBERG, Jan , RIEGER, Manfred , SCHEIFLINGER, Friedrich
IPC分类号： C07K16/36 , A61K39/395 , A61P7/04
CPC分类号： C07K14/755 , A61K38/00 , A61K39/00 , C07K14/775 , C07K16/36 , C07K2317/622 , C07K2317/76
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公开(公告)号：EP2231707B1
公开(公告)日：2014-12-24
申请号：EP08869976.4
申请日：2008-12-30
发明人： KERSCHBAUMER, Randolf , SCHEIFLINGER, Friedrich , RIEGER, Manfred , THIELE, Michael , MUDDE, C. Geert , MUELLBERG, Juergen , HOET, Rene
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2231707A1
公开(公告)日：2010-09-29
申请号：EP08869976.4
申请日：2008-12-30
发明人： KERSCHBAUMER, Randolf , SCHEIFLINGER, Friedrich , RIEGER, Manfred , THIELE, Michael , MUDDE, C. Geert , MUELLBERG, Juergen , HOET, Rene
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present application relates to monoclonal antibodies and antigen-binding portions thereof, that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The application also relates to isolated heavy and light chain immunoglobulins derived from the anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present application also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
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5.发明公开DIAGNOSTIC ASSAY FOR ANTI-VON WILLEBRAND FACTOR CLEAVING PROTEASE (ADAMTS13) ANTIBODIES 有权诊断测定抗血管性血友病因子切割蛋白酶（ADAMTS13）抗体
公开(公告)号：EP1616188A1
公开(公告)日：2006-01-18
申请号：EP04725025.3
申请日：2004-04-01
IPC分类号： G01N33/566 , C12Q1/37
摘要： This invention relates to a kit to be used in an assay system for determination of an anti-von Willebrand Factor-cleaving protease ('anti-vWF-cp') antibody in a sample. The kit comprises vWF-cp and/or vWF-fragment(s) immobilized on a solid phase. The kit can be used in a method for determination of anti-vWF-cp antibodies from a patient, for the diagnosis of disorders associated with the occurrence of anti-vWF-cp-antibodies, and the differentiation of various forms of thrombotic microangiopathy.
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6.发明授权DIAGNOSTIC ASSAY FOR ANTI-VON WILLEBRAND FACTOR CLEAVING PROTEASE (ADAMTS13) ANTIBODIES 有权诊断测定抗血管性血友病因子切割蛋白酶（ADAMTS13）抗体
公开(公告)号：EP1616188B1
公开(公告)日：2013-03-06
申请号：EP04725025.3
申请日：2004-04-01
IPC分类号： G01N33/566 , C12Q1/37
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