公开(公告)号：EP0984954A1

公开(公告)日：2000-03-15

申请号：EP98908991.7

申请日：1998-03-06

申请人： BAYLOR UNIVERSITY ,  Arizona Disease Control Research Commission

发明人： PINNEY, Kevin, G. ,  PETTIT, George, R. ,  MOCHARLA, Vani, P. ,  MEJIA, Ma. del Pilar ,  SHIRALI, Anupama

IPC分类号： C07D333/64 ,  C07C49/115 ,  C07C43/205

CPC分类号： C07D333/50 ,  C07C43/23 ,  C07C49/84 ,  C07C205/37 ,  C07C2602/10 ,  C07D307/80 ,  C07D333/56 ,  C07D333/64

摘要： Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described. Additional aspects described here are certain diaryl ether benzo[b]thiophene derivatives. Also described are particular analogs derived from dihydronaphthalene which have proven particularly effective. Certain new benzofuran analogs are described, as well as certain sulfur oxide benzo[b]thiophene analogs. Important compounds described herein include the first nitrogen-containing derivatives of combretastatin. These include nitro, amino and azide combretastatin derivatives.