公开(公告)号：EP3260451A1

公开(公告)日：2017-12-27

申请号：EP16752384.4

申请日：2016-02-10

Applicant: JNC Corporation ,  JNC Petrochemical Corporation

Inventor： YANO Tomohiro

IPC: C07D333/54 ,  C07D333/56 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  C09K19/42 ,  G02F1/13

CPC classification number: C09K19/3491 ,  C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D409/04 ,  C07D409/08 ,  C07D409/10 ,  C07D409/12 ,  C09K19/30 ,  C09K19/32 ,  C09K19/34 ,  C09K19/42 ,  C09K19/54 ,  C09K19/542 ,  C09K19/586 ,  C09K2019/548 ,  G02F1/13

Abstract: Provided is a liquid crystal compound that has high stability to heat, light and so forth, a high clearing point, low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large negative dielectric anisotropy, a suitable elastic constant and excellent compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound and a liquid crystal display device including the composition.
The compound is represented by formula (1).

For example, R 1 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 2 to 10 carbons; R 2 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 3 to 10 carbons; ring A 1 is 1,4-cyclohexylene or 1,4-phenylene; ring A 2 is 1,4-cyclohexylene or 1,4-phenylene; Z 1 and Z 2 are a single bond; Z 3 is -O- or a single bond; and L 1 is F, CF 3 or CF 2 H.

Abstract translation: 本发明提供对热，光等的稳定性高，透明点高，液晶相的下限温度低，粘度小，适当的光学各向异性，负的介电各向异性大，适当的弹性常数，优异的液晶化合物 与其他液晶化合物的相容性，含有该化合物的液晶组合物和包含该组合物的液晶显示装置。 该化合物由式（1）表示。 例如，R 1为碳数1〜10的烷基，碳数1〜9的烷氧基或碳数2〜10的烯基。 R2为碳数1〜10的烷基，碳数1〜9的烷氧基或碳数3〜10的烯基。 环A1是1,4-亚环己基或1,4-亚苯基; 环A 2是1,4-亚环己基或1,4-亚苯基; Z1和Z2是单键; Z3是-O-或单键; 并且L1是F，CF 3或CF 2 H.

公开(公告)号：EP2911660A4

公开(公告)日：2016-10-19

申请号：EP13848425

申请日：2013-10-24

Applicant: UNIV ILLINOIS ,  THATCHER GREG R ,  TONETTI DEBRA ,  MOLLOY MARY ELLEN ,  MICHALSEN BRADLEY ,  QIN ZIHUI

Inventor： THATCHER GREGORY R ,  TONETTI DEBRA ,  MOLLOY MARY ELLEN ,  MICHALSEN BRADLEY ,  QIN ZIHUI

IPC: A61K31/381 ,  A61K31/38 ,  A61P35/00

CPC classification number: A61K31/381 ,  C07D333/64 ,  G01N33/57496 ,  G01N2333/91205 ,  G01N2800/52

Abstract: Disclosed herein are methods for treatment of estrogen-related medical disorders. The methods of treatment may comprise administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2800560A4

公开(公告)日：2016-07-20

申请号：EP13733550

申请日：2013-01-04

Applicant: MERZ NORTH AMERICA INC

Inventor： DELONG MITCHELL A ,  KVALNES KALLA LYNN ,  BOISSY RAYMOND

IPC: A61K31/05 ,  A61K8/33 ,  C07D309/12 ,  C07H15/203

CPC classification number: C07D335/02 ,  A61K8/33 ,  A61K8/4926 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/4986 ,  A61K8/602 ,  A61K8/69 ,  A61K2800/591 ,  A61Q19/02 ,  C07D215/22 ,  C07D215/227 ,  C07D307/20 ,  C07D309/10 ,  C07D309/12 ,  C07D311/02 ,  C07D311/94 ,  C07D313/04 ,  C07D313/18 ,  C07D319/12 ,  C07D333/32 ,  C07D333/48 ,  C07D333/64 ,  C07D493/04 ,  C07H15/203

Abstract: Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the compounds of the present disclosure, namely chiral, non-racemic compounds, function as pigment formation inhibitors thereof to beautify skin and discourage the production of melanins. One or more products, consumer and otherwise, comprising the chiral, non-racemic compounds are disclosed herein. Methods of employing both the compounds of the present disclosure and the products incorporating the present compounds are also disclosed herein.

公开(公告)号：EP2838891A1

公开(公告)日：2015-02-25

申请号：EP13710076.4

申请日：2013-02-22

Applicant: Takeda Pharmaceutical Company Limited

Inventor： TAKAKURA, Nobuyuki ,  BANNO, Yoshihiro ,  TERAO, Yoshito ,  OCHIDA, Atsuko ,  MORIMOTO, Sachie ,  KITAMURA, Shuji ,  TOMATA, Yoshihide ,  YASUMA, Tsuneo ,  IKOMA, Minoru ,  MASUDA, Kei

IPC: C07D333/60 ,  C07D407/14 ,  C07D417/12 ,  C07D495/04 ,  C07D307/82 ,  A61K31/381 ,  A61K31/343 ,  A61K31/4355 ,  A61K31/4365 ,  A61P3/04

CPC classification number: C07D333/60 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D307/84 ,  C07D333/54 ,  C07D333/64 ,  C07D333/70 ,  C07D405/04 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D417/12 ,  C07D495/04

Abstract: The present invention provides a compound having a GOAT inhibitory action, which is useful for the prophylaxis or treatment of obesity and the like, and has superior efficacy. The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供具有GOAT抑制作用的化合物，其可用于预防或治疗肥胖症等，并且具有优异的功效。 本发明是由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。

公开(公告)号：EP2040688B1

公开(公告)日：2014-04-02

申请号：EP07785841.3

申请日：2007-06-25

Applicant: SANOFI

Inventor： HACHTEL, Stephanie ,  DEDIO, Juergen ,  DEFOSSA, Elisabeth ,  GRUENEBERG, Sven ,  HEITSCH, Holger ,  BOCK, William ,  CHEN, Charlie ,  KOSLEY, Raymond ,  KUNG, Chung-Yi ,  PATEK, Marcel ,  SHER, Rosy ,  SHIMSHOCK, Stephen ,  WEICHSEL, Aleksandra

IPC: C07C235/66 ,  C07C233/83 ,  C07C237/48 ,  C07C311/29 ,  C07D213/65 ,  C07D333/64 ,  C07D215/26 ,  C07D233/60 ,  C07D295/088 ,  C07D307/24 ,  C07D333/16

CPC classification number: C07D333/16 ,  C07C233/83 ,  C07C235/66 ,  C07C237/48 ,  C07C311/29 ,  C07C2601/04 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07D213/65 ,  C07D215/26 ,  C07D233/60 ,  C07D295/088 ,  C07D307/24 ,  C07D333/64

公开(公告)号：EP2197869B1

公开(公告)日：2013-04-24

申请号：EP08836864.2

申请日：2008-09-22

Applicant: BASF SE

Inventor： HAYOZ, Pascal ,  YAMATO, Hitoshi ,  ASAKURA, Toshikage

IPC: C07D307/83 ,  C07D333/22 ,  C07D333/32 ,  C07D333/34 ,  C07D333/64 ,  G03F7/004

CPC classification number: C07D307/83 ,  B33Y70/00 ,  C07D307/82 ,  C07D333/22 ,  C07D333/32 ,  C07D333/34 ,  C07D333/64

公开(公告)号：EP2248809A1

公开(公告)日：2010-11-10

申请号：EP10007872.4

申请日：2006-03-27

Applicant: TOYAMA CHEMICAL CO., LTD.

Inventor： Saitoh, Akihito ,  Suzuki, Yoshiaki ,  Yonezawa, Kenji ,  Kawamura, Mitsuhide ,  Kusanagi, Takahiko ,  Nakai, Takashi

IPC: C07D333/54 ,  C07D333/64

CPC classification number: C07D333/54 ,  C07D333/64 ,  C07D409/12

Abstract: A propionic acid ester derivative represented by the general formula:

wherein R 1 represents a hydrogen atom or an unsubstituted or substituted alkyl, cycloalkyl or aryl group. The claimed compounds are used as intermediates in the production of 1-(3-[2-benzo[b]thiophen-5-yl-ethoxy]-propyl)-azetidin-3-ol having therapeutic activity against central nervous system and peripheral nerve diseases.

Abstract translation: 由以下通式表示的丙酸酯衍生物：其中R 1表示氢原子或未取代或取代的烷基，环烷基或芳基。 所要求保护的化合物用作生产具有对中枢神经系统和周围神经的治疗活性的1-（3- [2-苯并[b]噻吩-5-基 - 乙氧基] - 丙基） - 氮杂环丁-3-醇的中间体 疾病。

公开(公告)号：EP1363880A4

公开(公告)日：2008-10-08

申请号：EP02709901

申请日：2002-02-01

Applicant: UNIV AUSTRALIAN ,  US GOV HEALTH & HUMAN SERV

Inventor： FLYNN BERNARD LUKE ,  HAMEL ERNEST

IPC: A61K31/122 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/565 ,  A61P35/00 ,  C07B61/00 ,  C07C45/63 ,  C07C45/65 ,  C07C45/67 ,  C07C47/575 ,  C07C49/755 ,  C07C49/84 ,  C07C323/21 ,  C07C323/22 ,  C07D209/12 ,  C07D307/80 ,  C07D307/83 ,  C07D311/30 ,  C07D333/16 ,  C07D333/22 ,  C07D333/28 ,  C07D333/56 ,  C07D333/62 ,  C07D333/64 ,  C07D407/04 ,  C07D495/04 ,  C07J71/00 ,  C40B40/04 ,  C07D209/02 ,  C07C45/72 ,  C07C49/255 ,  C07C323/20 ,  C07D307/86 ,  C07D333/26

CPC classification number: C40B40/04 ,  C07C45/63 ,  C07C45/65 ,  C07C45/67 ,  C07C45/673 ,  C07C47/575 ,  C07C49/755 ,  C07C49/84 ,  C07C323/21 ,  C07C323/22 ,  C07D209/12 ,  C07D307/80 ,  C07D307/83 ,  C07D311/30 ,  C07D333/16 ,  C07D333/22 ,  C07D333/28 ,  C07D333/56 ,  C07D333/62 ,  C07D333/64 ,  C07D407/04 ,  C07D495/04 ,  C07J71/00

公开(公告)号：EP1641774B1

公开(公告)日：2008-09-03

申请号：EP04751764.4

申请日：2004-05-27

Applicant: ELI LILLY AND COMPANY

Inventor： DODGE, Jeffrey, Alan ,  HUGHES, Norman, Earle

IPC: C07D333/64 ,  C07C323/16 ,  A61K31/10 ,  A61K31/381 ,  A61P35/00

CPC classification number: C07D333/64 ,  C07C317/18 ,  C07C323/12

Abstract: The present invention provides a compound of the formula (I) wherein R is -H, or -C1-C4 alkyl; R1 is -H, -OH, -O(C1-C4 alkyl), -SO2(C1-C4 alkyl), or halo; X is -O-, -CH2-, or -C(O)-; X1 is -O- or -NR2-; R2 is -H or -CH3; Y is -S-, -CH2CH2-, or -HC=CH-; m is 0, 1, 2, or 3; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen.

公开(公告)号：EP1947097A1

公开(公告)日：2008-07-23

申请号：EP06822953.3

申请日：2006-10-27

Applicant: Teijin Pharma Limited

Inventor： YAJIMA, Naoki ,  SATO, Yoshinori ,  YOSHINO, Hiroshi ,  KOIZUMI, Tatsuya ,  HIROKI, Yasuhiro

IPC: C07D333/56 ,  C07C333/04 ,  C07D333/62 ,  C07D409/06 ,  C07D409/14 ,  C07D471/04

CPC classification number: C07C333/04 ,  C07D333/56 ,  C07D333/62 ,  C07D333/64

Abstract: The invention provides benzo[b]thiophene derivatives useful as production intermediates for chymase inhibitors, and a process for their production.
The invention relates to benzo[b]thiophene derivatives represented by the following formula, and a process for their production.

Abstract translation: 本发明提供可用作胃促胰酶抑制剂的生产中间体的苯并[b]噻吩衍生物及其生产方法。 本发明涉及由下式表示的苯并[b]噻吩衍生物及其制备方法。