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公开(公告)号：EP2154147A4
公开(公告)日：2011-11-02
申请号：EP08748431
申请日：2008-04-29
发明人： GU YING , LI SHAOWEI , WEI MINXI , XIAN YANGLING , LUO WENXIN , XIA NINGSHAO
IPC分类号： C07K14/025 , A61K39/12 , A61P15/02 , A61P31/20 , A61P35/00 , C07K1/18 , C12N7/02 , C12N15/37
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2710/20022 , C12N2710/20034
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2.发明公开TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 52 有权VERKÜRZTESL1蛋白DES人类PAPILLOMAVIRUS VOM TYP 52
公开(公告)号：EP2589604A4
公开(公告)日：2013-12-18
申请号：EP11800199
申请日：2011-07-01
发明人： LI SHAOWEI , MO XIAOBING , WEI MINXI , PAN HUIRONG , ZHANG JUN , XIA NINGSHAO
IPC分类号： C07K14/025 , A61K39/12 , A61P31/20 , C12N1/21 , C12N15/70
CPC分类号： C07K14/025 , A61K39/0011 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C07K14/005 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2710/20051 , C12P21/02
摘要： Provided is a truncated L1 protein of Human Papillomavirus (HPV) Type 52 which, compared to a wild type HPV52 L1 protein, is truncated by 27-42 amino acids at the N-terminal. Also provided are a coding sequence of the truncated HPV52 L1 protein, a virus-like particle (VLP) comprising the protein, and a method of preparing the protein and the VLP using an E. coli expression system. The truncated HPV52 L1 protein and an assembled VLP can be used to prevent an HPV52 infection and a disease caused by HPV52 infection, such as cervical cancer.
摘要翻译： 提供了52型人乳头瘤病毒（HPV）截短的L1蛋白，其与野生型HPV52 L1蛋白相比在N-末端被截短27-42个氨基酸。 还提供了截短的HPV52 L1蛋白的编码序列，包含该蛋白的病毒样颗粒（VLP），以及使用大肠杆菌表达系统制备蛋白和VLP的方法。 截短的HPV52 L1蛋白和组装的VLP可用于预防HPV52感染和由HPV52感染引起的疾病，如宫颈癌。
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公开(公告)号：EP2716653A4
公开(公告)日：2015-01-21
申请号：EP12788749
申请日：2012-05-22
发明人： LI SHAOWEI , KONG XIANGLIN , WEI MINXI , PAN HUIRONG , ZHANG JUN , XIA NINGSHAO
IPC分类号： C07K14/025 , A61K39/12 , A61P31/20 , A61P35/00 , C07K1/16 , C07K1/30 , C12N7/04 , C12N15/37 , C12N15/63
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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公开(公告)号：EP2594579A4
公开(公告)日：2014-01-08
申请号：EP11806304
申请日：2011-07-15
发明人： LI SHAOWEI , WEI MINXI , KONG XIANGLIN , WANG YINGBIN , ZHANG JUN , XIA NINGSHAO
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K2039/5258 , A61K2039/585 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle comprising the protein. Uses of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine are further provided. The pharmaceutical composition or vaccine is used for prevention of HPV infection and a disease caused by HPV infection.
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