公开(公告)号：EP0575405A4

公开(公告)日：1994-03-02

申请号：EP92906293

申请日：1992-02-04

申请人： BERLEX LABORATORIES, INC.

发明人： PARKER BOTEHLO, LYNNE, HARTLAND ,  GARRIGAN, MARIA, CELESTE ,  JOHNS, ANTHONY ,  LEVINSON, BARRY, LEWIS ,  PATTERSON, KATHLEEN, CONWAY ,  POLOKOFF, MARK, ADAIR

IPC分类号： C12N9/64 ,  C12N9/14

CPC分类号： C12N9/6497 ,  C12Y304/24071

摘要： Human lung endothelin converting enzyme has been isolated in nearly homogeniously pure form. The enzyme is a zinc containing neutral metalloproteinase which is strongly inhibited by phosphoramidon. The enzyme has a subunit mass of about 100 kda and apparent masses of about 232 and 440 kda by gel filtration.

摘要翻译： 已经以几乎同质纯的形式分离人肺内皮素转化酶。 该酶是含锌的中性金属蛋白酶，其被磷酰二肽强烈抑制。 该酶通过凝胶过滤具有约100kda的亚基质量和约232和440kda的表观质量。