公开(公告)号：EP2655363B1

公开(公告)日：2017-04-12

申请号：EP11811184.8

申请日：2011-12-21

申请人： Bial-Portela & CA, S.A.

发明人： BELIAEV, Alexander ,  LEARMONTH, David, Alexander ,  BROADBELT, Brian ,  ALBERT, Ekaterina ,  ANDRES, Patricia

IPC分类号： C07D405/04

CPC分类号： C07D405/04

公开(公告)号：EP2606035A1

公开(公告)日：2013-06-26

申请号：EP11749010.2

申请日：2011-07-28

申请人： BIAL - Portela & CA., S.A.

发明人： LEARMONTH, David Alexander ,  BROADBELT, Brian ,  WAHNON, Jorge Bruno Reis

IPC分类号： C07D233/90 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D233/90 ,  C07D233/60 ,  C07D233/61 ,  C07D233/64 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

摘要： A process for preparing a substitute urea of Formula (II) or Formula (I), or a pharmaceutically acceptable salt or ester thereof, Formula (II): Formula (I): the process comprising the reaction of a carbamate of Formula (II'): or formula (I'): with a primary or secondary amine of the formula: R1R2NH, wherein ring A, and R1, R2, R5, V, W, X, Y and Z are as defined herein.

公开(公告)号：EP2655363A2

公开(公告)日：2013-10-30

申请号：EP11811184.8

申请日：2011-12-21

申请人： Bial-Portela & CA, S.A.

发明人： BELIAEV, Alexander ,  LEARMONTH, David, Alexander ,  BROADBELT, Brian ,  ALBERT, Ekaterina ,  ANDRES, Patricia

IPC分类号： C07D405/04

CPC分类号： C07D405/04

摘要： The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine.

公开(公告)号：EP2217585A2

公开(公告)日：2010-08-18

申请号：EP08850447.7

申请日：2008-11-13

申请人： BIAL - Portela & Ca., S.A.

发明人： BROADBELT, Brian ,  BELIAEV, Alexander ,  LEARMONTH, David

IPC分类号： C07D311/74

CPC分类号： C07D311/04

摘要： Compounds of formula I, V, VI and II, and processes for their preparation, wherein R
1 , R
2 and R
3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R
4 is alkyl or aryl. There is also provided a process for preparing a compound of formula B from the compounds of formula V and I.

公开(公告)号：EP2606035B1

公开(公告)日：2017-09-06

申请号：EP11749010.2

申请日：2011-07-28

申请人： BIAL - Portela & CA., S.A.

发明人： LEARMONTH, David Alexander ,  BROADBELT, Brian ,  WAHNON, Jorge Bruno Reis

IPC分类号： C07D233/90 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D405/12 ,  C07D405/14

CPC分类号： C07D233/90 ,  C07D233/60 ,  C07D233/61 ,  C07D233/64 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12