公开(公告)号：EP2170255A4

公开(公告)日：2013-12-04

申请号：EP08766506

申请日：2008-06-20

申请人： BIOCARE CO LTD ,  NEWTREE CO LTD

发明人： HWANG JAE-KWAN ,  LEE HAE JI ,  LEE JAE YOUNG ,  SHIM JAE-SEOK ,  KIM JEONG HWAN ,  KIM DO UN ,  CHUNG HEECHUL ,  CHUNG JAE YOUN

IPC分类号： A61K8/34 ,  A61K8/49 ,  A61K8/97 ,  A61Q19/08

CPC分类号： A61K8/97 ,  A61K8/347 ,  A61K8/498 ,  A61Q19/08

摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠中分离和纯化用于抗皱，更具体地说，本发明涉及一种用于抗皱的提取物的抗皱的新颖用途 肉豆蔻或肉豆蔻，脆弱蛋白A，奥维菌素7，睫毛膏E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的活性，从而具有抑制由 光老化。 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。