公开(公告)号：EP2170255A4

公开(公告)日：2013-12-04

申请号：EP08766506

申请日：2008-06-20

申请人： BIOCARE CO LTD ,  NEWTREE CO LTD

发明人： HWANG JAE-KWAN ,  LEE HAE JI ,  LEE JAE YOUNG ,  SHIM JAE-SEOK ,  KIM JEONG HWAN ,  KIM DO UN ,  CHUNG HEECHUL ,  CHUNG JAE YOUN

IPC分类号： A61K8/34 ,  A61K8/49 ,  A61K8/97 ,  A61Q19/08

CPC分类号： A61K8/97 ,  A61K8/347 ,  A61K8/498 ,  A61Q19/08

摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠中分离和纯化用于抗皱，更具体地说，本发明涉及一种用于抗皱的提取物的抗皱的新颖用途 肉豆蔻或肉豆蔻，脆弱蛋白A，奥维菌素7，睫毛膏E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的活性，从而具有抑制由 光老化。 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

公开(公告)号：EP2351559A2

公开(公告)日：2011-08-03

申请号：EP09819415.2

申请日：2009-10-09

申请人： NEWTREE CO., LTD. ,  Hwang, Jae-Kwan

发明人： HWANG, Jae-Kwan ,  KIM, Do Un

IPC分类号： A61K31/05 ,  A61K36/906 ,  A61P3/04 ,  A23L1/29

CPC分类号： A23C9/152 ,  A23L2/02 ,  A23L2/52 ,  A23L13/67 ,  A23L23/00 ,  A23L33/105 ,  A23L33/30 ,  A61K31/121 ,  A61K36/906

摘要： The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes. As can be seen foregoing, the present invention provides a novel use of a panduratin derivative or a Boesenbergia pandurata extract. A panduratin derivative or a Boesenbergia pandurata extract of the present invention shows excellent effects on a metabolic disease such as obesity, hyperlipidemia, hypercholesterolemia and diabetes by decreasing highly related causes of metabolic diseases such as on weight, body fat and lipid-content. Since a composition of the present invention is originated from natural materials, it can be used without side effect and provides novel method for preventing and treating/relieving a metabolic disease through body weight loss and body fat loss and the like.

摘要翻译： 本发明涉及一种潘多汀衍生物或蒲公英提取物的新用途。 更具体地说，本发明涉及含有由化学式1,2或3表示的潘多肽衍生物或者一种Boesenbergia pandurata提取物的预防和治疗选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的组合物 作为活性成分，可以通过向有需要的受试者施用有效量的潘多汀衍生物或Boesenbergia pandurata提取物来治疗选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的方法，以及使用 的潘多汀衍生物或Boesenbergia pandurata提取物，以制备用于预防和治疗或减轻选自肥胖症，高脂血症，高胆固醇血症和糖尿病的代谢疾病的试剂。 从前面可以看出，本发明提供了一种潘多汀衍生物或一种Boesenbergia pandurata提取物的新用途。 本发明的潘多林衍生物或泛黄柏提取物通过降低代谢性疾病如重量，体脂肪和脂质含量的高度相关原因，对肥胖症，高脂血症，高胆固醇血症和糖尿病等代谢疾病表现出优异的效果。 由于本发明的组合物来自天然材料，因此可以无副作用地使用，并且通过体重减轻和身体脂肪减少等提供预防和治疗/减轻代谢疾病的新方法。

公开(公告)号：EP2170255B1

公开(公告)日：2019-11-27

申请号：EP08766506.3

申请日：2008-06-20

申请人： AAT Costech Co., Ltd. ,  NEWTREE CO., LTD.

发明人： HWANG, Jae-Kwan ,  LEE, Hae Ji ,  LEE, Jae Young ,  SHIM, Jae-Seok ,  KIM, Jeong Hwan ,  KIM, Do Un ,  CHUNG, Heechul ,  CHUNG, Jae Youn

IPC分类号： A61K8/34 ,  A61K8/49 ,  A61K8/9789 ,  A61Q19/08

公开(公告)号：EP2200574A4

公开(公告)日：2015-11-18

申请号：EP08840361

申请日：2008-10-17

申请人： NEWTREE CO LTD

发明人： WHANG JAE-KWAN ,  SHIM JAE-SEOK ,  GWON SONG HUI ,  KWON YI YOUNG ,  OH HYUN IN ,  HAN YOUNG SUN ,  CHOI EUN JUNG ,  KIM DO UN

IPC分类号： A61K8/35 ,  A61K8/97 ,  A61Q19/08

CPC分类号： A61K8/35 ,  A61K8/97 ,  A61K2800/91 ,  A61Q19/08

摘要： The present invention relates to a new use of panduratin derivatives or a Kaempferia pandurata extract comprising the same. More particularly, the present invention relates to a composition for improving wrinkles and/or preventing aging, which comprises a panduratin derivative or a Kaempferia pandurata extract comprising the same. The said the panduratin derivative or the Kaempferia pandurata extract comprising the same induces cell proliferation, inhibits degradation of collagen, and promotes synthesis of collagen, therefore, it shows excellent activity in prevention of aging, particularly preventing, improving or treating wrinkle and it can be used as an effective ingredient in a cosmetic, food or pharmaceutical composition.

摘要翻译： 本发明涉及潘多汀衍生物的新用途或包含其的白头翁提取物。 更具体地，本发明涉及一种用于改善皱纹和/或防止老化的组合物，其包含潘杜林衍生物或包含其的山茶提取物。 所述的潘多汀衍生物或含有它们的山茱萸提取物诱导细胞增殖，抑制胶原蛋白的降解，促进胶原蛋白的合成，因此在防止老化，特别是防止，改善或治疗皱纹方面表现出优异的活性，并且可以 用作化妆品，食品或药物组合物中的有效成分。

公开(公告)号：EP2572710A4

公开(公告)日：2013-11-27

申请号：EP11783791

申请日：2011-05-20

申请人： BIOCARE CO LTD ,  NEWTREE CO LTD

发明人： HWANG JAE-KWAN ,  KIM DO UN

IPC分类号： A61K31/05 ,  A61K36/906 ,  A61P21/00 ,  A61P43/00

CPC分类号： A61K36/906 ,  A23L33/105 ,  A61K31/12 ,  A61K36/00

摘要： The present invention relates to the novel use of panduratin derivatives or an extract of Boesenbergia pandurata for enhancing muscle mass growth, fighting fatigue and enhancing exercise performance, and more particularly to a composition for promoting an increase in muscles, anti-fatigue composition and a composition for enhancing muscle mass growth and recovery from fatigue to improve exercise performance, the composition comprising a panduratin derivative or a salt thereof or an extract of Boesenbergia pandurata as an active ingredient, and to a method for enhancing muscle mass growth, of treating or preventing fatigue syndrome and enhancing exercise performance, the method comprising a panduratin derivative or a salt thereof or a extract of Boesenbergia pandurata to a subject in need thereof. A panduratin derivative or a salt thereof or an extract of Boesenbergia pandurata of the present invention may be used without side effect and has the effect of increasing the expression of PPAR-´ in muscles to increase muscle mass, promoting recovery from fatigue and increase mobility, thereby improving exercise performance.

公开(公告)号：EP2200574B1

公开(公告)日：2019-06-26

申请号：EP08840361.3

申请日：2008-10-17

申请人： NEWTREE CO., LTD.

发明人： HWANG, Jae-Kwan ,  SHIM, Jae-Seok ,  GWON, Song Hui ,  KWON, Yi Young ,  OH, Hyun In ,  HAN, Young Sun ,  CHOI, Eun Jung ,  KIM, Do Un

IPC分类号： A61K8/35 ,  A61Q19/08 ,  A61K8/97

公开(公告)号：EP2572710B1

公开(公告)日：2018-04-11

申请号：EP11783791.4

申请日：2011-05-20

申请人： Biocare Co., Ltd. ,  NEWTREE CO., LTD.

发明人： HWANG, Jae-Kwan ,  KIM, Do Un

IPC分类号： A61P43/00 ,  A61P21/00 ,  A61K31/05 ,  A61K36/906

CPC分类号： A61K36/906 ,  A23L33/105 ,  A61K31/12 ,  A61K36/00

摘要： The present invention relates to the novel use of panduratin derivatives or an extract of Boesenbergia pandurata for enhancing muscle mass growth, fighting fatigue and enhancing exercise performance, and more particularly to a composition for promoting an increase in muscles, anti-fatigue composition and a composition for enhancing muscle mass growth and recovery from fatigue to improve exercise performance, the composition comprising a panduratin derivative or a salt thereof or an extract of Boesenbergia pandurata as an active ingredient, and to a method for enhancing muscle mass growth, of treating or preventing fatigue syndrome and enhancing exercise performance, the method comprising a panduratin derivative or a salt thereof or a extract of Boesenbergia pandurata to a subject in need thereof. A panduratin derivative or a salt thereof or an extract of Boesenbergia pandurata of the present invention may be used without side effect and has the effect of increasing the expression of PPAR-´ in muscles to increase muscle mass, promoting recovery from fatigue and increase mobility, thereby improving exercise performance.

公开(公告)号：EP2351559A4

公开(公告)日：2012-03-28

申请号：EP09819415

申请日：2009-10-09

申请人： NEWTREE CO LTD ,  HWANG JAE KWAN

发明人： HWANG JAE-KWAN ,  KIM DO UN

IPC分类号： A61K31/05 ,  A23L1/29 ,  A61K31/121 ,  A61K36/906 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

CPC分类号： A23C9/152 ,  A23L2/02 ,  A23L2/52 ,  A23L13/67 ,  A23L23/00 ,  A23L33/105 ,  A23L33/30 ,  A61K31/121 ,  A61K36/906

摘要： The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes. As can be seen foregoing, the present invention provides a novel use of a panduratin derivative or a Boesenbergia pandurata extract. A panduratin derivative or a Boesenbergia pandurata extract of the present invention shows excellent effects on a metabolic disease such as obesity, hyperlipidemia, hypercholesterolemia and diabetes by decreasing highly related causes of metabolic diseases such as on weight, body fat and lipid-content. Since a composition of the present invention is originated from natural materials, it can be used without side effect and provides novel method for preventing and treating/relieving a metabolic disease through body weight loss and body fat loss and the like.

公开(公告)号：EP3453398A1

公开(公告)日：2019-03-13

申请号：EP17792915.5

申请日：2017-05-02

申请人： Newtree Co., Ltd.

发明人： HWANG, Jae Kwan ,  LEE, Se In ,  KIM, Mi Bo ,  KIM, Chang Hee ,  KIM, Doun. ,  CHUNG, Heechul. ,  KIM, Hyeongmin

IPC分类号： A61K36/48 ,  A23L33/105 ,  A61K8/97 ,  A61Q19/00

摘要： Vigna angularis var. angularis according to the present invention is capable of increasing muscle mass and enhancing muscular function or exercise performance through an effect of promoting mRNA or protein expression and the activity of a gene involved in muscle functions, muscle mass increase of differentiation of muscle cells; can prevent, treat or ameliorate a decline in exercise performance, a decline in muscle function, muscle loss, etc. caused by various diseases; and may be effectively used for medicines or food products, etc., since it has no side effects in the body as natural substance.

公开(公告)号：EP2200576A4

公开(公告)日：2013-12-04

申请号：EP08839723

申请日：2008-10-17

申请人： BIOCARE CO LTD ,  NEWTREE CO LTD

发明人： HWANG JAE-KWAN ,  CHO YU-MI ,  KIM GYU HOI ,  KIM JEONG HWAN ,  LEE HAE JI ,  OH HYUN IN ,  CHUNG HEE CHUL ,  CHUNG JAE YOUN ,  KIM DO UN

IPC分类号： A61K8/49 ,  A61K8/97 ,  A61Q19/02

CPC分类号： A61Q19/02 ,  A61K8/4973 ,  A61K8/97 ,  A61K31/357 ,  A61K36/185

摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.

摘要翻译： 本发明涉及木质素型化合物或含有该木素素类化合物的肉豆蔻或肉豆蔻酸的提取物的新用途。 更具体地，本发明涉及一种皮肤美白组合物，其包含木素素型化合物或包含该组合物的肉豆蔻或肉豆蔻的提取物。 由于化学式1〜3所示的木酚素化合物或肉豆蔻肉豆蔻酸的提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤美白活性，因此可用于制备化妆品组合物，食品组合物或药物组合物 用于皮肤美白。