公开(公告)号：EP1959979A4

公开(公告)日：2010-01-27

申请号：EP06836888

申请日：2006-11-03

申请人： BIOGEN IDEC INC ,  MCLEAN HOSPITAL CORP

发明人： MI SHA ,  ISACSON OLE

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C12N15/113 ,  C12N15/115

CPC分类号： A61K38/1709 ,  A61K39/0007 ,  A61K48/005 ,  C12N15/1138 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2799/027 ,  C12N2799/06

摘要： The present invention relates generally to methods for promoting regeneration, outgrowth and survival of dopaminergic neurons comprising contacting said dopaminergic neurons with an effective amount of a composition comprising an Sp35 antagonist. Additionally, the invention is related generally to methods of treating various diseases, disorders or injuries associated with dopaminergic neuronal degeneration or death by administration of an Sp35 antagonist.

公开(公告)号：EP1318822A4

公开(公告)日：2006-01-18

申请号：EP01962311

申请日：2001-07-27

申请人： MCLEAN HOSPITAL CORP

发明人： ISACSON OLE ,  KIM KWANG SOO

IPC分类号： A61K35/12 ,  A61K35/00

CPC分类号： C12N5/0606 ,  A61K35/30 ,  C12N5/0619 ,  C12N2501/38 ,  C12N2506/02 ,  C12N2510/00

摘要： Disclosed herein is a method for generating functional lineage-restricted progenitors from embryonic stem cells for obtaining donor cells of specific neuronal cell-fate, in sufficient quantities for the unmet cell transplantation need for treating patients with neurodegenerative diseases or disorders.