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    ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF
    1.
    发明公开
    ANTI-GPIIB/IIIA ANTIBODIES OR USES THEREOF 审中-公开
    ANTI-GPIIB / IIIA-ANTIKÖRPERODER VERWENDUNGEN DAVON

    公开(公告)号：EP3003368A4

    公开(公告)日：2017-05-03

    申请号：EP14801129

    申请日：2014-05-23

    Applicant: BIOGEN MA INC

    Inventor： SALAS JOE ,  TAN SIYUAN ,  PETERS ROBERT

    IPC: A61K39/395 ,  C07H21/00 ,  G01N33/53

    CPC classification number: C07K16/2848 ,  C07K14/755 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2319/33 ,  C12N9/6408 ,  C12N9/6437 ,  C12Y304/21021

    Abstract: The present invention provides antibodies and antigen-binding molecules thereof which specifically bind the α and/or &bgr; subunits of the non-active form of the GPIIb/IIIIa receptor. The antibodies and antigen-binding molecules can be genetically fused and/or conjugated to heterologous moieties and used, for example, as targeting moieties. The invention also includes methods for screening for these antibodies, as well as methods of making and methods of using chimeric molecules derived from the antibodies.

    Abstract translation: 本发明提供了特异性结合α和/或β珠蛋白的抗体及其抗原结合分子。 GPIIb / IIIaa受体的非活性形式的亚基。 抗体和抗原结合分子可以遗传融合和/或缀合至异源部分，并用作例如靶向部分。 本发明还包括筛选这些抗体的方法，以及制备和使用衍生自抗体的嵌合分子的方法和方法。

    PROCOAGULANT COMPOUNDS
    3.
    发明公开
    PROCOAGULANT COMPOUNDS 有权
    PROKOAGULATIONSVERBINDUNGEN

    公开(公告)号：EP2858659A4

    公开(公告)日：2016-09-28

    申请号：EP13799785

    申请日：2013-06-07

    Applicant: BIOGEN MA INC

    Inventor： HONG VU PHONG ,  MEZO ADAM R ,  SALAS JOE ,  PETERS ROBERT

    IPC: A61K38/02 ,  A61K38/36 ,  A61K38/48 ,  A61P7/02 ,  C12N9/64

    CPC classification number: C12N9/6437 ,  A61K38/02 ,  A61K38/36 ,  A61K38/4846 ,  C12N9/6432

    Abstract: The present disclosure provides protease-activatable procoagulant compounds comprising a procoagulant polypeptide, e.g., a procoagulant peptide and/or clotting factor, and a linker comprising a protease-cleavable substrate (e.g., a synthetic thrombin substrate) and a self-immolative spacer (e.g., p-amino benzyl carbamate). Upon cleavage of the protease-cleavable substrate by a protease (e.g., thrombin), the self-immolative spacer cleaves itself from the procoagulant polypeptide such that the polypeptide is in an underivatized and active form. Also provided are pharmaceutical compositions, methods for treating bleeding disefficacy orders using the disclosed compounds, methods of enhancing in vivo of procoagulant polypeptides, methods of increasing the efficacy of proteolytic cleavage of compounds comprising procoagulant polypeptides, methods of activating procoagulant polypeptides, and methods of releasing a procoagulant polypeptide from a heterologous moiety such as PEG.

    CHIMERIC FACTOR VIII POLYPEPTIDES AND USES THEREOF
    5.
    发明公开
    CHIMERIC FACTOR VIII POLYPEPTIDES AND USES THEREOF 审中-公开
    CHIMÄREFAKTOR-VII POLYPEPTIDE UND VERWENDUNGEN DAVON

    公开(公告)号：EP2804623A4

    公开(公告)日：2015-12-02

    申请号：EP13735649

    申请日：2013-01-12

    Applicant: BIOGEN MA INC

    Inventor： CHHABRA EKTA SETH ,  LIU TONGYAO ,  PETERS ROBERT ,  JIANG HAIYAN

    IPC: A61K38/37

    CPC classification number: C07K14/755 ,  A61K38/37 ,  A61K47/62 ,  C07K16/00 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/31

    Abstract: The present invention provides a VWF fragment comprising the D′ domain and D3 domain of VWF, a chimeric protein comprising the VWF fragment and a heterologous moiety, or a chimeric protein comprising the VWF fragment and a FVIII protein and methods of using the same. A polypeptide chain comprising a VWF fragment of the invention binds to or is associated with a polypeptide chain comprising a FVIII protein and the polypeptide chain comprising the VWF fragment can prevent or inhibit binding of endogenous VWF to the FVIII protein. By preventing or inhibiting binding of endogenous VWF to the FVIII, which is a half-life limiting factor for FVIII, the VWF fragment can induce extension of half-life of the FVIII protein. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.

    Abstract translation: 本发明提供了包含VWF的D'结构域和D3结构域的VWF片段，包含VWF片段和异源部分的嵌合蛋白质，或包含VWF片段和FVIII蛋白质的嵌合蛋白质及其使用方法。 包含本发明的VWF片段的多肽链与包含FVIII蛋白的多肽链结合或相关，并且包含VWF片段的多肽链可以预防或抑制内源性VWF与FVIII蛋白的结合。 通过预防或抑制内源VWF与作为FVIII的半衰期限制因子的FVIII的结合，VWF片段可诱导FVIII蛋白的半衰期延长。 本发明还包括核苷酸，载体，宿主细胞，使用VWF片段或嵌合蛋白的方法。

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