公开(公告)号：EP3402537A1

公开(公告)日：2018-11-21

申请号：EP17738231.4

申请日：2017-01-13

Applicant: Rigshospitalet

Inventor： KJAER, Andreas ,  HAAGEN NIELSEN, Carsten

IPC: A61K51/08 ,  A61K38/36 ,  A61K49/00 ,  C12N9/64

CPC classification number: C12N9/6408 ,  A61K38/4846 ,  A61K51/088 ,  C12N9/64

Abstract: There is provided a positron-emitting 18F-labelled Factor VIIfor non-invasive PET imaging of tumor TF expression in humans. More specifically the invention relates to human TFPET imaging of pancreaticcancer metastasis for diagnosis, staging, treatment monitoring and especially as an imaging biomarker for predicting prognosis, progression and recurrence.

公开(公告)号：EP3003368A4

公开(公告)日：2017-05-03

申请号：EP14801129

申请日：2014-05-23

Applicant: BIOGEN MA INC

Inventor： SALAS JOE ,  TAN SIYUAN ,  PETERS ROBERT

IPC: A61K39/395 ,  C07H21/00 ,  G01N33/53

CPC classification number: C07K16/2848 ,  C07K14/755 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2319/33 ,  C12N9/6408 ,  C12N9/6437 ,  C12Y304/21021

Abstract: The present invention provides antibodies and antigen-binding molecules thereof which specifically bind the α and/or &bgr; subunits of the non-active form of the GPIIb/IIIIa receptor. The antibodies and antigen-binding molecules can be genetically fused and/or conjugated to heterologous moieties and used, for example, as targeting moieties. The invention also includes methods for screening for these antibodies, as well as methods of making and methods of using chimeric molecules derived from the antibodies.

Abstract translation: 本发明提供了特异性结合α和/或β珠蛋白的抗体及其抗原结合分子。 GPIIb / IIIaa受体的非活性形式的亚基。 抗体和抗原结合分子可以遗传融合和/或缀合至异源部分，并用作例如靶向部分。 本发明还包括筛选这些抗体的方法，以及制备和使用衍生自抗体的嵌合分子的方法和方法。

公开(公告)号：EP2869832A4

公开(公告)日：2016-10-26

申请号：EP13791047

申请日：2013-05-14

Applicant: UNIV SAINT LOUIS

Inventor： POZZI NICOLA ,  DI CERA ENRICO ,  BARRANCO-MEDINA SERGIO

IPC: A61K38/48 ,  C12N9/64 ,  C12N9/74

CPC classification number: C12N9/6429 ,  C12N9/6408 ,  C12Y304/21005

公开(公告)号：EP2719764B1

公开(公告)日：2016-10-26

申请号：EP12800088.2

申请日：2012-05-21

Applicant: Chong Kun Dang Pharmaceutical Corp.

Inventor： KOH, Yeo-Wook ,  LEE, Sang-Yong ,  KIM, Su-Yon ,  MOON, Seung-Kee

IPC: C12N15/85 ,  C12N5/10 ,  C12N15/12 ,  C12N9/64

CPC classification number: C12P21/00 ,  C12N9/6408 ,  C12N15/85 ,  C12N2830/46 ,  C12N2830/85

公开(公告)号：EP2930241A4

公开(公告)日：2016-08-03

申请号：EP13862466

申请日：2013-12-10

Applicant: SEIKAGAKU KOGYO CO LTD

Inventor： MIZUMURA HIKARU ,  ODA TOSHIO ,  KAWABATA SHUN-ICHIRO

IPC: C12N15/09 ,  C12N9/64 ,  C12P21/02 ,  C12Q1/37 ,  G01N33/569 ,  G01N33/579

CPC classification number: C12N9/6408 ,  C12Y304/21069 ,  C12Y304/21084 ,  G01N33/56911 ,  G01N33/579 ,  G01N2333/96411

Abstract: The present invention relates to methods for mitigating a reaction inhibition in endotoxin assay in the presence of a salt ion, methods for producing a water soluble horseshoe crab Factor C for use in endotoxin assay in the presence of a salt ion, and methods for measuring endotoxin in a test specimen.

公开(公告)号：EP3034607A1

公开(公告)日：2016-06-22

申请号：EP15199395.3

申请日：2007-07-05

Applicant: Catalyst Biosciences, Inc.

Inventor： MADISON, Edwin

IPC: C12N9/64 ,  C12N15/10 ,  C12N9/50 ,  C12N9/72

CPC classification number: C12N15/1037 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/41 ,  C07K2319/42 ,  C12N9/50 ,  C12N9/6408 ,  C12N9/6462 ,  C12Q1/37 ,  C12Y304/21073 ,  C12Y304/21109 ,  G01N33/6842

Abstract: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a seipin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.

Abstract translation: 提供了用于鉴定修饰的底物特异性或其它性质的修饰蛋白酶的方法。 通过使筛选候选物和修饰的蛋白酶与底物（例如塞皮肽，α聚球蛋白或p35家族蛋白或修饰的丝氨酸蛋白酶和修饰的p35家族成员或修饰的α聚球蛋白）接触来筛选候选物和修饰的蛋白酶，在基质切割时， 蛋白酶通过形成稳定的复合物。 还提供了修饰的蛋白酶。

公开(公告)号：EP2480662A1

公开(公告)日：2012-08-01

申请号：EP10819456.4

申请日：2010-09-23

Applicant: Potomac Affinity Proteins, Inc.

Inventor： BRYAN, Philip, N.

IPC: C12N9/50 ,  C12N11/00

CPC classification number: C12N9/54 ,  C12N9/6408 ,  C12N9/6424 ,  C12N15/01 ,  C12Y304/21062

Abstract: The present invention provides a new method for engineering or evolving enzymes to have desirable characteristics. Among the desirable characteristics is the ability to control catalytic activity through the use of a trigger molecule that rescues a catalytic site defect introduced during the engineering process. The method includes co-evolving enzyme and substrate to retain or improve substrate binding activity in the absence of catalytic activity.

公开(公告)号：EP2402437A2

公开(公告)日：2012-01-04

申请号：EP11173352.3

申请日：2007-07-05

Applicant: Catalyst Biosciences, Inc. ,  Torrey Pines Institute For Molecular Studies

Inventor： Madison, Edwin

IPC: C12N9/64 ,  C12N15/10 ,  C12N9/50 ,  C12N9/72

CPC classification number: C12N15/1037 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/41 ,  C07K2319/42 ,  C12N9/50 ,  C12N9/6408 ,  C12N9/6462 ,  C12Q1/37 ,  C12Y304/21073 ,  C12Y304/21109 ,  G01N33/6842

Abstract: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macro globulins or a p35 5 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases

Abstract translation: 提供了用于鉴定修饰的底物特异性或其它性质的修饰蛋白酶的方法。 通过使筛选候选物和修饰的蛋白酶与底物如丝氨酸蛋白酶抑制剂，α宏观球蛋白或p355家族蛋白质或修饰的丝氨酸蛋白酶和修饰的p35家族成员或修饰的α巨球蛋白接触来筛选候选物质和修饰的蛋白酶， 通过形成稳定的复合物捕获蛋白酶。 还提供了修饰的蛋白酶

公开(公告)号：EP2385985A1

公开(公告)日：2011-11-16

申请号：EP09771362.2

申请日：2009-12-11

Applicant: Nestec S.A.

Inventor： PRIDMORE, Raymond-David ,  ARIGONI, Fabrizio ,  MAYNARD, Françoise ,  BUREAU-FRANZ, Isabelle

IPC: C12N9/76 ,  C12P1/06 ,  A23J3/08 ,  A23J3/34

CPC classification number: C12P1/06 ,  A23J3/343 ,  A23L33/18 ,  C12N9/6408

Abstract: The present invention generally relates to edible compositions and methods to produce them. In particular, the present invention relates to the enzymatic modulation of macron utrients and to food compositions containing such modulated macronutrients. One embodiment of the present invention is a method for modulating macronutrients comprising the steps of producing at least one synthetic gene coding for at least one enzyme or a functional part thereof capable of modulating macronutrients, expressing the at least one enzyme or a functional part thereof, and bringing the macronutrients into contact with the at least one enzyme or a functional part thereof exhibiting the enzymatic activity.

公开(公告)号：EP2226382A1

公开(公告)日：2010-09-08

申请号：EP09003063.6

申请日：2009-03-03

Applicant: B.R.A.I.N. Biotechnology Research and Information Network AG

Inventor： Niehaus, Frank ,  Eck, Jürgen ,  Schulze, Renate

IPC: C12N9/64 ,  C07K16/40 ,  A61K38/43 ,  C12N15/62 ,  C12N5/10

CPC classification number: C12N9/6408

Abstract: We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or having the amino acid sequence of SEQ ID NO: 2; (b) a nucleic acid molecule comprising or having the nucleotide sequence of SEQ ID NO: 1; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80 % identical to the amino acid sequence of (a), preferably at least 85 % identical, more preferably at least 90 % identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or having a nucleotide sequence which is at least 80 % identical to the nucleotide sequence of (b), preferably at least 85 % identical, more preferably at least 90 % identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.

Abstract translation: 我们已经通过分子克隆鉴定了源于丝绢幼虫的蛋白酶，由于其可用于清创伤口的活性，所述蛋白酶被称为脱氨酶。 描述了编码具有裂解纤维蛋白和酪蛋白的能力的丝氨酸蛋白酶的核酸分子，其是（a）编码包含或具有SEQ ID NO：2的氨基酸序列的丝氨酸蛋白酶的核酸分子; （b）包含或具有SEQ ID NO：1的核苷酸序列的核酸分子; （c）编码丝氨酸蛋白酶的核酸分子，其氨基酸序列与（a）的氨基酸序列至少80％相同，优选至少85％相同，更优选至少90％相同，最多 优选95％相同; （d）核酸分子，其包含或具有与（b）的核苷酸序列至少80％相同的核苷酸序列，优选至少85％相同，更优选至少90％相同，最优选95％相同的核苷酸序列 ; （e）相对于（b）或（d）的核酸分子简并的核酸分子; 或（f）对应于（a）至（d）中任一项的核酸分子的核酸分子，其中T被U替代