专利检索 ap:("BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION") AND inv:"WHEELER, Matthew B." 第 1 页

1.

发明授权
EMBRYONIC STEM CELLS FOR MAKING CHIMERIC AND TRANSGENIC UNGULATES 失效
标题翻译：中产生嵌合和TRANSGEN-ONGULATEN的干细胞小生境胚胎

公开(公告)号：EP0701608B1

公开(公告)日：1999-09-15

申请号：EP94919157.1

申请日：1994-05-16

申请人： BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： WHEELER, Matthew B.

IPC分类号： C12N15/00 , A01K67/027 , C12N5/06 , G01N33/50

CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/108 , A01K2267/02 , C12N5/0606 , C12N15/873 , C12N2502/14 , C12N2510/00

2.

发明公开
EMBRYONIC STEM CELLS FOR MAKING CHIMERIC AND TRANSGENIC UNGULATES 失效
标题翻译：中产生嵌合和TRANSGEN-ONGULATEN的干细胞小生境胚胎

公开(公告)号：EP0701608A1

公开(公告)日：1996-03-20

申请号：EP94919157.0

申请日：1994-05-16

申请人： BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION

发明人： WHEELER, Matthew B.

IPC分类号： C12N15 , A01K67 , C12N5

CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/101 , A01K2227/102 , A01K2227/103 , A01K2227/108 , A01K2267/02 , C12N5/0606 , C12N15/873 , C12N2502/14 , C12N2510/00

摘要： Transgenic ungulates and compositions and methods for making and using same, are provided. Central to the invention are porcine, bovine, ovine and caprine embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric ungulates which have germ cells comprising the exogenous genetic material. The chimeric ungulates are bred to provide transgenic ungulates. The transgenic animals of the invention may show improved qualities and can be used to provide human proteins or peptide hormones or can be used as xenograft donors.